KSR1- and ERK-dependent translational regulation of the epithelial-to-mesenchymal transition
The epithelial-to-mesenchymal transition (EMT) is considered a transcriptional process that induces a switch in cells from a polarized state to a migratory phenotype. Here, we show that KSR1 and ERK promote EMT-like phenotype through the preferential translation of Epithelial-Stromal Interaction 1 (...
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Auteurs principaux: | Chaitra Rao, Danielle E Frodyma, Siddesh Southekal, Robert A Svoboda, Adrian R Black, Chittibabu Guda, Tomohiro Mizutani, Hans Clevers, Keith R Johnson, Kurt W Fisher, Robert E Lewis |
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Format: | article |
Langue: | EN |
Publié: |
eLife Sciences Publications Ltd
2021
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Sujets: | |
Accès en ligne: | https://doaj.org/article/88d3c636f9184176abf9681d4d5cfcad |
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