Guanine nucleotide exchange factor H1 can be a new biomarker of melanoma

Jie Shi, Bingyu Guo, Yu Zhang, Qiang Hui, Peng Chang, Kai Tao Reconstructive and Plastic Surgery, The General Hospital of Shenyang Military Region, Shenyang, People’s Republic of China Abstract: Guanine nucleotide exchange factor H1 (GEF-H1), wh...

Descripción completa

Guardado en:

Detalles Bibliográficos
Autores principales:	Shi J, Guo BY, Zhang Y, Hui Q, Chang P, Tao K
Formato:	article
Lenguaje:	EN
Publicado:	Dove Medical Press 2016
Materias:	GEF-H1 melanoma cancer biomarker proliferation metastasis Medicine (General) R5-920
Acceso en línea:	https://doaj.org/article/88d405b809ad4304b46393213ffe466a
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

id	oai:doaj.org-article:88d405b809ad4304b46393213ffe466a
record_format	dspace
spelling	oai:doaj.org-article:88d405b809ad4304b46393213ffe466a2021-12-02T07:11:42ZGuanine nucleotide exchange factor H1 can be a new biomarker of melanoma1177-5491https://doaj.org/article/88d405b809ad4304b46393213ffe466a2016-07-01T00:00:00Zhttps://www.dovepress.com/guanine-nucleotide-exchange-factor-h1-can-be-a-new-biomarker-of-melano-peer-reviewed-article-BTThttps://doaj.org/toc/1177-5491Jie Shi, Bingyu Guo, Yu Zhang, Qiang Hui, Peng Chang, Kai Tao Reconstructive and Plastic Surgery, The General Hospital of Shenyang Military Region, Shenyang, People’s Republic of China Abstract: Guanine nucleotide exchange factor H1 (GEF-H1), which couples microtubule dynamics to RhoA activation, is a microtubule-regulated exchange factor. Studies have shown that GEF-H1 can be involved in various cancer pathways; however, the clinical significance of GEF-H1 expression and functions in melanoma has not been established. In this study, we investigated the relationship between clinical outcomes and GEF-H1 functions in melanoma. A  total of 60 cases of different grades of melanoma samples were used to detect the expression of GEF-H1. Results showed that both messenger RNA and protein levels of GEF-H1 were significantly higher in high-grade melanomas. Furthermore, patients with high GEF-H1 expression had a shorter overall survival (22 months) than patients with low level of GEF-H1 expression (33.38 months).We also found that GEF-H1 can promote the proliferation and metastasis of melanoma cells. In summary, these results suggested that GEF-H1 may be a valuable biomarker for assessing the degree and prognosis of melanoma following surgery. Keywords: GEF-H1, melanoma, biomarker, proliferation, metastasisShi JGuo BYZhang YHui QChang PTao KDove Medical PressarticleGEF-H1melanoma cancerbiomarkerproliferationmetastasisMedicine (General)R5-920ENBiologics: Targets & Therapy, Vol 2016, Iss Issue 1, Pp 89-98 (2016)
institution	DOAJ
collection	DOAJ
language	EN
topic	GEF-H1 melanoma cancer biomarker proliferation metastasis Medicine (General) R5-920
spellingShingle	GEF-H1 melanoma cancer biomarker proliferation metastasis Medicine (General) R5-920 Shi J Guo BY Zhang Y Hui Q Chang P Tao K Guanine nucleotide exchange factor H1 can be a new biomarker of melanoma
description	Jie Shi, Bingyu Guo, Yu Zhang, Qiang Hui, Peng Chang, Kai Tao Reconstructive and Plastic Surgery, The General Hospital of Shenyang Military Region, Shenyang, People’s Republic of China Abstract: Guanine nucleotide exchange factor H1 (GEF-H1), which couples microtubule dynamics to RhoA activation, is a microtubule-regulated exchange factor. Studies have shown that GEF-H1 can be involved in various cancer pathways; however, the clinical significance of GEF-H1 expression and functions in melanoma has not been established. In this study, we investigated the relationship between clinical outcomes and GEF-H1 functions in melanoma. A  total of 60 cases of different grades of melanoma samples were used to detect the expression of GEF-H1. Results showed that both messenger RNA and protein levels of GEF-H1 were significantly higher in high-grade melanomas. Furthermore, patients with high GEF-H1 expression had a shorter overall survival (22 months) than patients with low level of GEF-H1 expression (33.38 months).We also found that GEF-H1 can promote the proliferation and metastasis of melanoma cells. In summary, these results suggested that GEF-H1 may be a valuable biomarker for assessing the degree and prognosis of melanoma following surgery. Keywords: GEF-H1, melanoma, biomarker, proliferation, metastasis
format	article
author	Shi J Guo BY Zhang Y Hui Q Chang P Tao K
author_facet	Shi J Guo BY Zhang Y Hui Q Chang P Tao K
author_sort	Shi J
title	Guanine nucleotide exchange factor H1 can be a new biomarker of melanoma
title_short	Guanine nucleotide exchange factor H1 can be a new biomarker of melanoma
title_full	Guanine nucleotide exchange factor H1 can be a new biomarker of melanoma
title_fullStr	Guanine nucleotide exchange factor H1 can be a new biomarker of melanoma
title_full_unstemmed	Guanine nucleotide exchange factor H1 can be a new biomarker of melanoma
title_sort	guanine nucleotide exchange factor h1 can be a new biomarker of melanoma
publisher	Dove Medical Press
publishDate	2016
url	https://doaj.org/article/88d405b809ad4304b46393213ffe466a
work_keys_str_mv	AT shij guaninenucleotideexchangefactorh1canbeanewbiomarkerofmelanoma AT guoby guaninenucleotideexchangefactorh1canbeanewbiomarkerofmelanoma AT zhangy guaninenucleotideexchangefactorh1canbeanewbiomarkerofmelanoma AT huiq guaninenucleotideexchangefactorh1canbeanewbiomarkerofmelanoma AT changp guaninenucleotideexchangefactorh1canbeanewbiomarkerofmelanoma AT taok guaninenucleotideexchangefactorh1canbeanewbiomarkerofmelanoma
_version_	1718399584816857088

Guanine nucleotide exchange factor H1 can be a new biomarker of melanoma

Ejemplares similares