Untargeted metabolomics approach to discriminate mistletoe commercial products

Abstract Mistletoe (Viscum album L.) is used in German-speaking European countries in the field of integrative oncology linking conventional and complementary medicine therapies to improve quality of life. Various companies sell extracts, fermented or not, for injection by subcutaneous or intra-tumo...

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Autores principales:	Cécile Vanhaverbeke, David Touboul, Nicolas Elie, Martine Prévost, Cécile Meunier, Sylvie Michelland, Valérie Cunin, Ling Ma, David Vermijlen, Cédric Delporte, Stéphanie Pochet, Audrey Le Gouellec, Michel Sève, Pierre Van Antwerpen, Florence Souard
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/88d84196d80a4e45881e3536a0bc83e0
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spelling	oai:doaj.org-article:88d84196d80a4e45881e3536a0bc83e02021-12-02T16:14:55ZUntargeted metabolomics approach to discriminate mistletoe commercial products10.1038/s41598-021-93255-z2045-2322https://doaj.org/article/88d84196d80a4e45881e3536a0bc83e02021-07-01T00:00:00Zhttps://doi.org/10.1038/s41598-021-93255-zhttps://doaj.org/toc/2045-2322Abstract Mistletoe (Viscum album L.) is used in German-speaking European countries in the field of integrative oncology linking conventional and complementary medicine therapies to improve quality of life. Various companies sell extracts, fermented or not, for injection by subcutaneous or intra-tumoral route with a regulatory status of anthroposophic medicinal products (European Medicinal Agency (EMA) assessment status). These companies as well as anthroposophical physicians argue that complex matrices composed of many molecules in mixture are necessary for activity and that the host tree of the mistletoe parasitic plant is the main determining factor for this matrix composition. The critical point is that parenteral devices of European mistletoe extracts do not have a standard chemical composition regulated by EMA quality guidelines, because they are not drugs, regulatory speaking. However, the mechanism of mistletoe’s anticancer activity and its effectiveness in treating and supporting cancer patients are not fully understood. Because of this lack of transparency and knowledge regarding the matrix chemical composition, we undertook an untargeted metabolomics study of several mistletoe extracts to explore and compare their fingerprints by LC-(HR)MS(/MS) and 1H-NMR. Unexpectedly, we showed that the composition was primarily driven by the manufacturer/preparation method rather than the different host trees. This differential composition may cause differences in immunostimulating and anti-cancer activities of the different commercially available mistletoe extracts as illustrated by structure–activity relationships based on LC–MS/MS and 1H-NMR identifications completed by docking experiments. In conclusion, in order to move towards an evidence-based medicine use of mistletoe, it is a priority to bring rigor and quality, chemically speaking.Cécile VanhaverbekeDavid TouboulNicolas ElieMartine PrévostCécile MeunierSylvie MichellandValérie CuninLing MaDavid VermijlenCédric DelporteStéphanie PochetAudrey Le GouellecMichel SèvePierre Van AntwerpenFlorence SouardNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 11, Iss 1, Pp 1-13 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Cécile Vanhaverbeke David Touboul Nicolas Elie Martine Prévost Cécile Meunier Sylvie Michelland Valérie Cunin Ling Ma David Vermijlen Cédric Delporte Stéphanie Pochet Audrey Le Gouellec Michel Sève Pierre Van Antwerpen Florence Souard Untargeted metabolomics approach to discriminate mistletoe commercial products
description	Abstract Mistletoe (Viscum album L.) is used in German-speaking European countries in the field of integrative oncology linking conventional and complementary medicine therapies to improve quality of life. Various companies sell extracts, fermented or not, for injection by subcutaneous or intra-tumoral route with a regulatory status of anthroposophic medicinal products (European Medicinal Agency (EMA) assessment status). These companies as well as anthroposophical physicians argue that complex matrices composed of many molecules in mixture are necessary for activity and that the host tree of the mistletoe parasitic plant is the main determining factor for this matrix composition. The critical point is that parenteral devices of European mistletoe extracts do not have a standard chemical composition regulated by EMA quality guidelines, because they are not drugs, regulatory speaking. However, the mechanism of mistletoe’s anticancer activity and its effectiveness in treating and supporting cancer patients are not fully understood. Because of this lack of transparency and knowledge regarding the matrix chemical composition, we undertook an untargeted metabolomics study of several mistletoe extracts to explore and compare their fingerprints by LC-(HR)MS(/MS) and 1H-NMR. Unexpectedly, we showed that the composition was primarily driven by the manufacturer/preparation method rather than the different host trees. This differential composition may cause differences in immunostimulating and anti-cancer activities of the different commercially available mistletoe extracts as illustrated by structure–activity relationships based on LC–MS/MS and 1H-NMR identifications completed by docking experiments. In conclusion, in order to move towards an evidence-based medicine use of mistletoe, it is a priority to bring rigor and quality, chemically speaking.
format	article
author	Cécile Vanhaverbeke David Touboul Nicolas Elie Martine Prévost Cécile Meunier Sylvie Michelland Valérie Cunin Ling Ma David Vermijlen Cédric Delporte Stéphanie Pochet Audrey Le Gouellec Michel Sève Pierre Van Antwerpen Florence Souard
author_facet	Cécile Vanhaverbeke David Touboul Nicolas Elie Martine Prévost Cécile Meunier Sylvie Michelland Valérie Cunin Ling Ma David Vermijlen Cédric Delporte Stéphanie Pochet Audrey Le Gouellec Michel Sève Pierre Van Antwerpen Florence Souard
author_sort	Cécile Vanhaverbeke
title	Untargeted metabolomics approach to discriminate mistletoe commercial products
title_short	Untargeted metabolomics approach to discriminate mistletoe commercial products
title_full	Untargeted metabolomics approach to discriminate mistletoe commercial products
title_fullStr	Untargeted metabolomics approach to discriminate mistletoe commercial products
title_full_unstemmed	Untargeted metabolomics approach to discriminate mistletoe commercial products
title_sort	untargeted metabolomics approach to discriminate mistletoe commercial products
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/88d84196d80a4e45881e3536a0bc83e0
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Untargeted metabolomics approach to discriminate mistletoe commercial products

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