Pkd2l1 is required for mechanoception in cerebrospinal fluid-contacting neurons and maintenance of spine curvature
Alteration of cerebrospinal fluid (CSF) flow and cilia defects are clinically associated with idiopathic scoliosis. This study shows that transient receptor potential channel Pkd2l1 is required for mechanosensory function of neurons detecting CSF flow and normal spine curvature development in zebraf...
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Nature Portfolio
2018
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oai:doaj.org-article:88d9999b54c84d7280f863923497f69e2021-12-02T17:32:44ZPkd2l1 is required for mechanoception in cerebrospinal fluid-contacting neurons and maintenance of spine curvature10.1038/s41467-018-06225-x2041-1723https://doaj.org/article/88d9999b54c84d7280f863923497f69e2018-09-01T00:00:00Zhttps://doi.org/10.1038/s41467-018-06225-xhttps://doaj.org/toc/2041-1723Alteration of cerebrospinal fluid (CSF) flow and cilia defects are clinically associated with idiopathic scoliosis. This study shows that transient receptor potential channel Pkd2l1 is required for mechanosensory function of neurons detecting CSF flow and normal spine curvature development in zebrafish.Jenna R. SternbergAndrew E. PrendergastLucie BrosseYasmine Cantaut-BelarifOlivier ThouveninAdeline Orts-Del’ImmagineLaura CastilloLydia DjenouneShusaku KurisuJonathan R. McDearmidPierre-Luc BardetClaude BoccaraHitoshi OkamotoPatrick DelmasClaire WyartNature PortfolioarticleScienceQENNature Communications, Vol 9, Iss 1, Pp 1-10 (2018) |
| institution |
DOAJ |
| collection |
DOAJ |
| language |
EN |
| topic |
Science Q |
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Science Q Jenna R. Sternberg Andrew E. Prendergast Lucie Brosse Yasmine Cantaut-Belarif Olivier Thouvenin Adeline Orts-Del’Immagine Laura Castillo Lydia Djenoune Shusaku Kurisu Jonathan R. McDearmid Pierre-Luc Bardet Claude Boccara Hitoshi Okamoto Patrick Delmas Claire Wyart Pkd2l1 is required for mechanoception in cerebrospinal fluid-contacting neurons and maintenance of spine curvature |
| description |
Alteration of cerebrospinal fluid (CSF) flow and cilia defects are clinically associated with idiopathic scoliosis. This study shows that transient receptor potential channel Pkd2l1 is required for mechanosensory function of neurons detecting CSF flow and normal spine curvature development in zebrafish. |
| format |
article |
| author |
Jenna R. Sternberg Andrew E. Prendergast Lucie Brosse Yasmine Cantaut-Belarif Olivier Thouvenin Adeline Orts-Del’Immagine Laura Castillo Lydia Djenoune Shusaku Kurisu Jonathan R. McDearmid Pierre-Luc Bardet Claude Boccara Hitoshi Okamoto Patrick Delmas Claire Wyart |
| author_facet |
Jenna R. Sternberg Andrew E. Prendergast Lucie Brosse Yasmine Cantaut-Belarif Olivier Thouvenin Adeline Orts-Del’Immagine Laura Castillo Lydia Djenoune Shusaku Kurisu Jonathan R. McDearmid Pierre-Luc Bardet Claude Boccara Hitoshi Okamoto Patrick Delmas Claire Wyart |
| author_sort |
Jenna R. Sternberg |
| title |
Pkd2l1 is required for mechanoception in cerebrospinal fluid-contacting neurons and maintenance of spine curvature |
| title_short |
Pkd2l1 is required for mechanoception in cerebrospinal fluid-contacting neurons and maintenance of spine curvature |
| title_full |
Pkd2l1 is required for mechanoception in cerebrospinal fluid-contacting neurons and maintenance of spine curvature |
| title_fullStr |
Pkd2l1 is required for mechanoception in cerebrospinal fluid-contacting neurons and maintenance of spine curvature |
| title_full_unstemmed |
Pkd2l1 is required for mechanoception in cerebrospinal fluid-contacting neurons and maintenance of spine curvature |
| title_sort |
pkd2l1 is required for mechanoception in cerebrospinal fluid-contacting neurons and maintenance of spine curvature |
| publisher |
Nature Portfolio |
| publishDate |
2018 |
| url |
https://doaj.org/article/88d9999b54c84d7280f863923497f69e |
| work_keys_str_mv |
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| _version_ |
1718380200284127232 |