Lateral opening in the intact β-barrel assembly machinery captured by cryo-EM
The β-barrel assembly machinery (BAM complex) is a key mediator of outer membrane protein biogenesis in Gram-negative bacteria. Here the authors report a cryo-EM structure of the intact BAM complex that suggests that lateral gate opening is a necessary part of the BAM functional cycle.
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Nature Portfolio
2016
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oai:doaj.org-article:88d9b9184d62412599a6be4be362ef282021-12-02T15:34:54ZLateral opening in the intact β-barrel assembly machinery captured by cryo-EM10.1038/ncomms128652041-1723https://doaj.org/article/88d9b9184d62412599a6be4be362ef282016-09-01T00:00:00Zhttps://doi.org/10.1038/ncomms12865https://doaj.org/toc/2041-1723The β-barrel assembly machinery (BAM complex) is a key mediator of outer membrane protein biogenesis in Gram-negative bacteria. Here the authors report a cryo-EM structure of the intact BAM complex that suggests that lateral gate opening is a necessary part of the BAM functional cycle.Matthew G. IadanzaAnna J. HigginsBob SchiffrinAntonio N. CalabreseDavid J. BrockwellAlison E. AshcroftSheena E. RadfordNeil A. RansonNature PortfolioarticleScienceQENNature Communications, Vol 7, Iss 1, Pp 1-12 (2016) |
| institution |
DOAJ |
| collection |
DOAJ |
| language |
EN |
| topic |
Science Q |
| spellingShingle |
Science Q Matthew G. Iadanza Anna J. Higgins Bob Schiffrin Antonio N. Calabrese David J. Brockwell Alison E. Ashcroft Sheena E. Radford Neil A. Ranson Lateral opening in the intact β-barrel assembly machinery captured by cryo-EM |
| description |
The β-barrel assembly machinery (BAM complex) is a key mediator of outer membrane protein biogenesis in Gram-negative bacteria. Here the authors report a cryo-EM structure of the intact BAM complex that suggests that lateral gate opening is a necessary part of the BAM functional cycle. |
| format |
article |
| author |
Matthew G. Iadanza Anna J. Higgins Bob Schiffrin Antonio N. Calabrese David J. Brockwell Alison E. Ashcroft Sheena E. Radford Neil A. Ranson |
| author_facet |
Matthew G. Iadanza Anna J. Higgins Bob Schiffrin Antonio N. Calabrese David J. Brockwell Alison E. Ashcroft Sheena E. Radford Neil A. Ranson |
| author_sort |
Matthew G. Iadanza |
| title |
Lateral opening in the intact β-barrel assembly machinery captured by cryo-EM |
| title_short |
Lateral opening in the intact β-barrel assembly machinery captured by cryo-EM |
| title_full |
Lateral opening in the intact β-barrel assembly machinery captured by cryo-EM |
| title_fullStr |
Lateral opening in the intact β-barrel assembly machinery captured by cryo-EM |
| title_full_unstemmed |
Lateral opening in the intact β-barrel assembly machinery captured by cryo-EM |
| title_sort |
lateral opening in the intact β-barrel assembly machinery captured by cryo-em |
| publisher |
Nature Portfolio |
| publishDate |
2016 |
| url |
https://doaj.org/article/88d9b9184d62412599a6be4be362ef28 |
| work_keys_str_mv |
AT matthewgiadanza lateralopeningintheintactbbarrelassemblymachinerycapturedbycryoem AT annajhiggins lateralopeningintheintactbbarrelassemblymachinerycapturedbycryoem AT bobschiffrin lateralopeningintheintactbbarrelassemblymachinerycapturedbycryoem AT antonioncalabrese lateralopeningintheintactbbarrelassemblymachinerycapturedbycryoem AT davidjbrockwell lateralopeningintheintactbbarrelassemblymachinerycapturedbycryoem AT alisoneashcroft lateralopeningintheintactbbarrelassemblymachinerycapturedbycryoem AT sheenaeradford lateralopeningintheintactbbarrelassemblymachinerycapturedbycryoem AT neilaranson lateralopeningintheintactbbarrelassemblymachinerycapturedbycryoem |
| _version_ |
1718386731412094976 |