Expression of CD25+ and CD95+ Surface Markers on Peripheral Blood Lymphocytes in Patients with Vibration Disease

Vibration disease occupies one of the leading places among occupational diseases. The development and course of vibration disease is accompanied by disorders in immune system.Aim of the study is to provide a comparative assessment of cells with markers of the early (CD25+) and late (CD95+) stage of...

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Autores principales:	S. I. Kurchevenko, G. M. Bodienkova
Formato:	article
Lenguaje:	RU
Publicado:	Scientific Сentre for Family Health and Human Reproduction Problems 2020
Materias:	vibration disease exposure to local and combined vibration lymphocyte populations and subpopulations Science Q
Acceso en línea:	https://doaj.org/article/88dd10962a83489a8283633bd0dedde7
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spelling	oai:doaj.org-article:88dd10962a83489a8283633bd0dedde72021-11-23T06:14:44ZExpression of CD25+ and CD95+ Surface Markers on Peripheral Blood Lymphocytes in Patients with Vibration Disease2541-94202587-959610.29413/ABS.2020-5.2.4https://doaj.org/article/88dd10962a83489a8283633bd0dedde72020-05-01T00:00:00Zhttps://www.actabiomedica.ru/jour/article/view/2305https://doaj.org/toc/2541-9420https://doaj.org/toc/2587-9596Vibration disease occupies one of the leading places among occupational diseases. The development and course of vibration disease is accompanied by disorders in immune system.Aim of the study is to provide a comparative assessment of cells with markers of the early (CD25+) and late (CD95+) stage of lymphocyte activation and to compare them with the phenotypic composition of lymphocytes in patients with vibration disease.Materials and methods. The study includes men aged 36-60 years with vibration disease from exposure to local vibration (26 people) and from combined exposure to local and general vibration (28 people).Results. The most pronounced changes in the system of lymphocyte apoptosis are observed in patients with vibration disease from the combined effects of local and general vibration, manifested by the increase in the number of CD25+ and CD95+-lymphocytes. Increase of quantity of CD25+ at patients with a vibration disease from impact of local vibration and from the combined impact of local and general vibration is caused by increase in their number on lymphocytes what the direct correlation dependence between quantity of CD25+-lymphocytes and the number of CD3+, CD4+, CD8+, CD16+, CD20+-lymphocytes testifies to.Conclusions. In patients with vibration disease from the combined effects of local and general vibration, the increase in the number of CD95+ is due to an increase in their density on mature T-lymphocytes, as evidenced by the inverse relationship between the level of CD95+ and the CD3+-lymphocytes. The obtained data should be taken into account in order to develop new effective methods of prevention, treatment and prediction of the course of vibration pathology.S. I. KurchevenkoG. M. BodienkovaScientific Сentre for Family Health and Human Reproduction Problemsarticlevibration diseaseexposure to local and combined vibrationlymphocyte populations and subpopulationsScienceQRUActa Biomedica Scientifica, Vol 5, Iss 2, Pp 24-27 (2020)
institution	DOAJ
collection	DOAJ
language	RU
topic	vibration disease exposure to local and combined vibration lymphocyte populations and subpopulations Science Q
spellingShingle	vibration disease exposure to local and combined vibration lymphocyte populations and subpopulations Science Q S. I. Kurchevenko G. M. Bodienkova Expression of CD25+ and CD95+ Surface Markers on Peripheral Blood Lymphocytes in Patients with Vibration Disease
description	Vibration disease occupies one of the leading places among occupational diseases. The development and course of vibration disease is accompanied by disorders in immune system.Aim of the study is to provide a comparative assessment of cells with markers of the early (CD25+) and late (CD95+) stage of lymphocyte activation and to compare them with the phenotypic composition of lymphocytes in patients with vibration disease.Materials and methods. The study includes men aged 36-60 years with vibration disease from exposure to local vibration (26 people) and from combined exposure to local and general vibration (28 people).Results. The most pronounced changes in the system of lymphocyte apoptosis are observed in patients with vibration disease from the combined effects of local and general vibration, manifested by the increase in the number of CD25+ and CD95+-lymphocytes. Increase of quantity of CD25+ at patients with a vibration disease from impact of local vibration and from the combined impact of local and general vibration is caused by increase in their number on lymphocytes what the direct correlation dependence between quantity of CD25+-lymphocytes and the number of CD3+, CD4+, CD8+, CD16+, CD20+-lymphocytes testifies to.Conclusions. In patients with vibration disease from the combined effects of local and general vibration, the increase in the number of CD95+ is due to an increase in their density on mature T-lymphocytes, as evidenced by the inverse relationship between the level of CD95+ and the CD3+-lymphocytes. The obtained data should be taken into account in order to develop new effective methods of prevention, treatment and prediction of the course of vibration pathology.
format	article
author	S. I. Kurchevenko G. M. Bodienkova
author_facet	S. I. Kurchevenko G. M. Bodienkova
author_sort	S. I. Kurchevenko
title	Expression of CD25+ and CD95+ Surface Markers on Peripheral Blood Lymphocytes in Patients with Vibration Disease
title_short	Expression of CD25+ and CD95+ Surface Markers on Peripheral Blood Lymphocytes in Patients with Vibration Disease
title_full	Expression of CD25+ and CD95+ Surface Markers on Peripheral Blood Lymphocytes in Patients with Vibration Disease
title_fullStr	Expression of CD25+ and CD95+ Surface Markers on Peripheral Blood Lymphocytes in Patients with Vibration Disease
title_full_unstemmed	Expression of CD25+ and CD95+ Surface Markers on Peripheral Blood Lymphocytes in Patients with Vibration Disease
title_sort	expression of cd25+ and cd95+ surface markers on peripheral blood lymphocytes in patients with vibration disease
publisher	Scientific Сentre for Family Health and Human Reproduction Problems
publishDate	2020
url	https://doaj.org/article/88dd10962a83489a8283633bd0dedde7
work_keys_str_mv	AT sikurchevenko expressionofcd25andcd95surfacemarkersonperipheralbloodlymphocytesinpatientswithvibrationdisease AT gmbodienkova expressionofcd25andcd95surfacemarkersonperipheralbloodlymphocytesinpatientswithvibrationdisease
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Expression of CD25+ and CD95+ Surface Markers on Peripheral Blood Lymphocytes in Patients with Vibration Disease

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