Increased cutaneous wound healing effect of biodegradable liposomes containing madecassoside: preparation optimization, in vitro dermal permeation, and in vivo bioevaluation

Zehao Li,1 Meifeng Liu,1 Huijuan Wang,1 Song Du21School of Chemistry and Chemical Engineering, Guangdong Provincial Key Laboratory for Green Chemical Product Technology, South China University of Technology, Guangzhou, 2Guangdong Jiabao Pharmaceutical Co., Ltd., Qingyuan, People’s Republic...

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Autores principales:	Li Z, Liu M, Wang H, Du S
Formato:	article
Lenguaje:	EN
Publicado:	Dove Medical Press 2016
Materias:	madecassoside liposomes double emulsion method skin permeation wound healing effect transdermal property Medicine (General) R5-920
Acceso en línea:	https://doaj.org/article/88dd2a53f255438586e5c54c4679e2fa
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spelling	oai:doaj.org-article:88dd2a53f255438586e5c54c4679e2fa2021-12-02T01:34:51ZIncreased cutaneous wound healing effect of biodegradable liposomes containing madecassoside: preparation optimization, in vitro dermal permeation, and in vivo bioevaluation1178-2013https://doaj.org/article/88dd2a53f255438586e5c54c4679e2fa2016-06-01T00:00:00Zhttps://www.dovepress.com/increased-cutaneous-wound-healing-effect-of-biodegradable-liposomes-co-peer-reviewed-article-IJNhttps://doaj.org/toc/1178-2013Zehao Li,1 Meifeng Liu,1 Huijuan Wang,1 Song Du21School of Chemistry and Chemical Engineering, Guangdong Provincial Key Laboratory for Green Chemical Product Technology, South China University of Technology, Guangzhou, 2Guangdong Jiabao Pharmaceutical Co., Ltd., Qingyuan, People’s Republic of ChinaAbstract: Madecassoside (MA) is highly potent in treating skin disorders such as wounds and psoriasis. However, the topical wound healing effect of MA was hampered by its poor membrane permeability. In order to overcome this shortcoming, MA liposomes were designed and prepared by a double-emulsion method to enhance transdermal and wound healing effects. In this study, response surface methodology was adopted to yield the optimal preparation conditions of MA double-emulsion liposomes with average particle size of 151 nm and encapsulation efficiency of 70.14%. Moreover, MA double-emulsion liposomes demonstrated superior stability and homogeneous appearance in 5 months; their leakage rate was <12% even at 37°C and <5% at 4°C within 1 month. In vitro skin permeation, skin distribution, and burn wound healing of MA liposomal formulations were conducted for the first time to evaluate MA delivery efficiency and wound healing effect. The transdermal property and wound cure effect of MA double-emulsion liposomes were superior to those of MA film dispersion liposomes, and both the methods were endowed with an excellent performance by polyethylene glycol modification. In conclusion, double-emulsion liposome formulation was an applicable and promising pharmaceutical preparation for enhancing MA delivery toward wound healing effect and improving wound-healing progress.Keywords: madecassoside liposomes, double-emulsion method, skin permeation, wound-healing effect, transdermal propertyLi ZLiu MWang HDu SDove Medical Pressarticlemadecassoside liposomesdouble emulsion methodskin permeationwound healing effecttransdermal propertyMedicine (General)R5-920ENInternational Journal of Nanomedicine, Vol 2016, Iss default, Pp 2995-3007 (2016)
institution	DOAJ
collection	DOAJ
language	EN
topic	madecassoside liposomes double emulsion method skin permeation wound healing effect transdermal property Medicine (General) R5-920
spellingShingle	madecassoside liposomes double emulsion method skin permeation wound healing effect transdermal property Medicine (General) R5-920 Li Z Liu M Wang H Du S Increased cutaneous wound healing effect of biodegradable liposomes containing madecassoside: preparation optimization, in vitro dermal permeation, and in vivo bioevaluation
description	Zehao Li,1 Meifeng Liu,1 Huijuan Wang,1 Song Du21School of Chemistry and Chemical Engineering, Guangdong Provincial Key Laboratory for Green Chemical Product Technology, South China University of Technology, Guangzhou, 2Guangdong Jiabao Pharmaceutical Co., Ltd., Qingyuan, People’s Republic of ChinaAbstract: Madecassoside (MA) is highly potent in treating skin disorders such as wounds and psoriasis. However, the topical wound healing effect of MA was hampered by its poor membrane permeability. In order to overcome this shortcoming, MA liposomes were designed and prepared by a double-emulsion method to enhance transdermal and wound healing effects. In this study, response surface methodology was adopted to yield the optimal preparation conditions of MA double-emulsion liposomes with average particle size of 151 nm and encapsulation efficiency of 70.14%. Moreover, MA double-emulsion liposomes demonstrated superior stability and homogeneous appearance in 5 months; their leakage rate was <12% even at 37°C and <5% at 4°C within 1 month. In vitro skin permeation, skin distribution, and burn wound healing of MA liposomal formulations were conducted for the first time to evaluate MA delivery efficiency and wound healing effect. The transdermal property and wound cure effect of MA double-emulsion liposomes were superior to those of MA film dispersion liposomes, and both the methods were endowed with an excellent performance by polyethylene glycol modification. In conclusion, double-emulsion liposome formulation was an applicable and promising pharmaceutical preparation for enhancing MA delivery toward wound healing effect and improving wound-healing progress.Keywords: madecassoside liposomes, double-emulsion method, skin permeation, wound-healing effect, transdermal property
format	article
author	Li Z Liu M Wang H Du S
author_facet	Li Z Liu M Wang H Du S
author_sort	Li Z
title	Increased cutaneous wound healing effect of biodegradable liposomes containing madecassoside: preparation optimization, in vitro dermal permeation, and in vivo bioevaluation
title_short	Increased cutaneous wound healing effect of biodegradable liposomes containing madecassoside: preparation optimization, in vitro dermal permeation, and in vivo bioevaluation
title_full	Increased cutaneous wound healing effect of biodegradable liposomes containing madecassoside: preparation optimization, in vitro dermal permeation, and in vivo bioevaluation
title_fullStr	Increased cutaneous wound healing effect of biodegradable liposomes containing madecassoside: preparation optimization, in vitro dermal permeation, and in vivo bioevaluation
title_full_unstemmed	Increased cutaneous wound healing effect of biodegradable liposomes containing madecassoside: preparation optimization, in vitro dermal permeation, and in vivo bioevaluation
title_sort	increased cutaneous wound healing effect of biodegradable liposomes containing madecassoside: preparation optimization, in vitro dermal permeation, and in vivo bioevaluation
publisher	Dove Medical Press
publishDate	2016
url	https://doaj.org/article/88dd2a53f255438586e5c54c4679e2fa
work_keys_str_mv	AT liz increasedcutaneouswoundhealingeffectofbiodegradableliposomescontainingmadecassosidepreparationoptimizationinvitrodermalpermeationandinvivobioevaluation AT lium increasedcutaneouswoundhealingeffectofbiodegradableliposomescontainingmadecassosidepreparationoptimizationinvitrodermalpermeationandinvivobioevaluation AT wangh increasedcutaneouswoundhealingeffectofbiodegradableliposomescontainingmadecassosidepreparationoptimizationinvitrodermalpermeationandinvivobioevaluation AT dus increasedcutaneouswoundhealingeffectofbiodegradableliposomescontainingmadecassosidepreparationoptimizationinvitrodermalpermeationandinvivobioevaluation
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Increased cutaneous wound healing effect of biodegradable liposomes containing madecassoside: preparation optimization, in vitro dermal permeation, and in vivo bioevaluation

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