Characteristics of asbestos fibers in lung tissue from occupational and environmental asbestos exposure of lung cancer patients in Busan, Korea

Abstract The Asbestos Injury Relief Act in Korea requires that asbestos exposure be assessed through clinical examination and chest computed tomography (CT). However, a more specific measurement of asbestos characteristics in the lung tissue may be appropriate. We aimed to investigate the asbestos b...

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Autores principales:	Hyun-Sung Jung, Eun-Kee Park, Jun-Seok Cha, Jae-Won Lee, Jong-Chun Lee, Jinyoung Jang, Suejin Kim, Chulho Oak, Deborah H. Yates, Hyunwook Kim
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2020
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/88dfa3975175480e9ab0b755168b1d5a
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spelling	oai:doaj.org-article:88dfa3975175480e9ab0b755168b1d5a2021-12-02T16:08:49ZCharacteristics of asbestos fibers in lung tissue from occupational and environmental asbestos exposure of lung cancer patients in Busan, Korea10.1038/s41598-020-77291-92045-2322https://doaj.org/article/88dfa3975175480e9ab0b755168b1d5a2020-11-01T00:00:00Zhttps://doi.org/10.1038/s41598-020-77291-9https://doaj.org/toc/2045-2322Abstract The Asbestos Injury Relief Act in Korea requires that asbestos exposure be assessed through clinical examination and chest computed tomography (CT). However, a more specific measurement of asbestos characteristics in the lung tissue may be appropriate. We aimed to investigate the asbestos burden and characterize asbestos fibers in patients with lung cancer and ultimately assess the relationship between occupational and environmental asbestos exposure and lung cancer in Korea. We evaluated 37 lung cancer patients (LCPs) from Busan. The factors affecting asbestos burden in LCPs were analyzed using a multiple regression analysis. History of asbestos exposure (environmental/occupational), male sex, and old age were the main factors affecting asbestos burden in lung tissues of LCPs. These factors had an approximate 37% adjusted coefficient of determination. There was a significant difference in the length of asbestos fibers (4.06–37.6 µm vs. 4.26–91.7 µm) and aspect ratio (4.5–151.9 vs. 5.6–735.6) between those who were occupationally exposed to asbestos and those who were environmentally exposed (P < 0.01). Therefore, both environmental/occupational exposure to asbestos should be strongly managed to reduce the risk of lung cancer, and exposure should be assessed according to the characteristics of asbestos fibers in the lung tissue.Hyun-Sung JungEun-Kee ParkJun-Seok ChaJae-Won LeeJong-Chun LeeJinyoung JangSuejin KimChulho OakDeborah H. YatesHyunwook KimNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 10, Iss 1, Pp 1-12 (2020)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Hyun-Sung Jung Eun-Kee Park Jun-Seok Cha Jae-Won Lee Jong-Chun Lee Jinyoung Jang Suejin Kim Chulho Oak Deborah H. Yates Hyunwook Kim Characteristics of asbestos fibers in lung tissue from occupational and environmental asbestos exposure of lung cancer patients in Busan, Korea
description	Abstract The Asbestos Injury Relief Act in Korea requires that asbestos exposure be assessed through clinical examination and chest computed tomography (CT). However, a more specific measurement of asbestos characteristics in the lung tissue may be appropriate. We aimed to investigate the asbestos burden and characterize asbestos fibers in patients with lung cancer and ultimately assess the relationship between occupational and environmental asbestos exposure and lung cancer in Korea. We evaluated 37 lung cancer patients (LCPs) from Busan. The factors affecting asbestos burden in LCPs were analyzed using a multiple regression analysis. History of asbestos exposure (environmental/occupational), male sex, and old age were the main factors affecting asbestos burden in lung tissues of LCPs. These factors had an approximate 37% adjusted coefficient of determination. There was a significant difference in the length of asbestos fibers (4.06–37.6 µm vs. 4.26–91.7 µm) and aspect ratio (4.5–151.9 vs. 5.6–735.6) between those who were occupationally exposed to asbestos and those who were environmentally exposed (P < 0.01). Therefore, both environmental/occupational exposure to asbestos should be strongly managed to reduce the risk of lung cancer, and exposure should be assessed according to the characteristics of asbestos fibers in the lung tissue.
format	article
author	Hyun-Sung Jung Eun-Kee Park Jun-Seok Cha Jae-Won Lee Jong-Chun Lee Jinyoung Jang Suejin Kim Chulho Oak Deborah H. Yates Hyunwook Kim
author_facet	Hyun-Sung Jung Eun-Kee Park Jun-Seok Cha Jae-Won Lee Jong-Chun Lee Jinyoung Jang Suejin Kim Chulho Oak Deborah H. Yates Hyunwook Kim
author_sort	Hyun-Sung Jung
title	Characteristics of asbestos fibers in lung tissue from occupational and environmental asbestos exposure of lung cancer patients in Busan, Korea
title_short	Characteristics of asbestos fibers in lung tissue from occupational and environmental asbestos exposure of lung cancer patients in Busan, Korea
title_full	Characteristics of asbestos fibers in lung tissue from occupational and environmental asbestos exposure of lung cancer patients in Busan, Korea
title_fullStr	Characteristics of asbestos fibers in lung tissue from occupational and environmental asbestos exposure of lung cancer patients in Busan, Korea
title_full_unstemmed	Characteristics of asbestos fibers in lung tissue from occupational and environmental asbestos exposure of lung cancer patients in Busan, Korea
title_sort	characteristics of asbestos fibers in lung tissue from occupational and environmental asbestos exposure of lung cancer patients in busan, korea
publisher	Nature Portfolio
publishDate	2020
url	https://doaj.org/article/88dfa3975175480e9ab0b755168b1d5a
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Characteristics of asbestos fibers in lung tissue from occupational and environmental asbestos exposure of lung cancer patients in Busan, Korea

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