Neighbor-enhanced diffusivity in dense, cohesive cell populations.

The dispersal or mixing of cells within cellular tissue is a crucial property for diverse biological processes, ranging from morphogenesis, immune action, to tumor metastasis. With the phenomenon of 'contact inhibition of locomotion,' it is puzzling how cells achieve such processes within...

Descripción completa

Guardado en:

Detalles Bibliográficos
Autores principales:	Hyun Gyu Lee, Kyoung J Lee
Formato:	article
Lenguaje:	EN
Publicado:	Public Library of Science (PLoS) 2021
Materias:	Biology (General) QH301-705.5
Acceso en línea:	https://doaj.org/article/88e46244388a4663b1400046e3576ddb
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

id	oai:doaj.org-article:88e46244388a4663b1400046e3576ddb
record_format	dspace
spelling	oai:doaj.org-article:88e46244388a4663b1400046e3576ddb2021-12-02T19:57:43ZNeighbor-enhanced diffusivity in dense, cohesive cell populations.1553-734X1553-735810.1371/journal.pcbi.1009447https://doaj.org/article/88e46244388a4663b1400046e3576ddb2021-09-01T00:00:00Zhttps://doi.org/10.1371/journal.pcbi.1009447https://doaj.org/toc/1553-734Xhttps://doaj.org/toc/1553-7358The dispersal or mixing of cells within cellular tissue is a crucial property for diverse biological processes, ranging from morphogenesis, immune action, to tumor metastasis. With the phenomenon of 'contact inhibition of locomotion,' it is puzzling how cells achieve such processes within a densely packed cohesive population. Here we demonstrate that a proper degree of cell-cell adhesiveness can, intriguingly, enhance the super-diffusive nature of individual cells. We systematically characterize the migration trajectories of crawling MDA-MB-231 cell lines, while they are in several different clustering modes, including freely crawling singles, cohesive doublets of two cells, quadruplets, and confluent population on two-dimensional substrate. Following data analysis and computer simulation of a simple cellular Potts model, which faithfully recapitulated all key experimental observations such as enhanced diffusivity as well as periodic rotation of cell-doublets and cell-quadruplets with mixing events, we found that proper combination of active self-propelling force and cell-cell adhesion is sufficient for generating the observed phenomena. Additionally, we found that tuning parameters for these two factors covers a variety of different collective dynamic states.Hyun Gyu LeeKyoung J LeePublic Library of Science (PLoS)articleBiology (General)QH301-705.5ENPLoS Computational Biology, Vol 17, Iss 9, p e1009447 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Biology (General) QH301-705.5
spellingShingle	Biology (General) QH301-705.5 Hyun Gyu Lee Kyoung J Lee Neighbor-enhanced diffusivity in dense, cohesive cell populations.
description	The dispersal or mixing of cells within cellular tissue is a crucial property for diverse biological processes, ranging from morphogenesis, immune action, to tumor metastasis. With the phenomenon of 'contact inhibition of locomotion,' it is puzzling how cells achieve such processes within a densely packed cohesive population. Here we demonstrate that a proper degree of cell-cell adhesiveness can, intriguingly, enhance the super-diffusive nature of individual cells. We systematically characterize the migration trajectories of crawling MDA-MB-231 cell lines, while they are in several different clustering modes, including freely crawling singles, cohesive doublets of two cells, quadruplets, and confluent population on two-dimensional substrate. Following data analysis and computer simulation of a simple cellular Potts model, which faithfully recapitulated all key experimental observations such as enhanced diffusivity as well as periodic rotation of cell-doublets and cell-quadruplets with mixing events, we found that proper combination of active self-propelling force and cell-cell adhesion is sufficient for generating the observed phenomena. Additionally, we found that tuning parameters for these two factors covers a variety of different collective dynamic states.
format	article
author	Hyun Gyu Lee Kyoung J Lee
author_facet	Hyun Gyu Lee Kyoung J Lee
author_sort	Hyun Gyu Lee
title	Neighbor-enhanced diffusivity in dense, cohesive cell populations.
title_short	Neighbor-enhanced diffusivity in dense, cohesive cell populations.
title_full	Neighbor-enhanced diffusivity in dense, cohesive cell populations.
title_fullStr	Neighbor-enhanced diffusivity in dense, cohesive cell populations.
title_full_unstemmed	Neighbor-enhanced diffusivity in dense, cohesive cell populations.
title_sort	neighbor-enhanced diffusivity in dense, cohesive cell populations.
publisher	Public Library of Science (PLoS)
publishDate	2021
url	https://doaj.org/article/88e46244388a4663b1400046e3576ddb
work_keys_str_mv	AT hyungyulee neighborenhanceddiffusivityindensecohesivecellpopulations AT kyoungjlee neighborenhanceddiffusivityindensecohesivecellpopulations
_version_	1718375789150339072

Neighbor-enhanced diffusivity in dense, cohesive cell populations.

Ejemplares similares