Human brain metastatic stroma attracts breast cancer cells via chemokines CXCL16 and CXCL12

Metastasis: brain metastases fuel further spread Breast cancer metastases to the brain secrete signaling molecules that promote additional cancer cells to migrate there. Peter P. Lee and colleagues from the City of Hope in Duarte, California, USA, analyzed protein and gene expression levels in brain...

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Autores principales:	Brile Chung, Ali A. Esmaeili, Sailesh Gopalakrishna-Pillai, John P. Murad, Emily S. Andersen, Naveen Kumar Reddy, Gayathri Srinivasan, Brian Armstrong, Caleb Chu, Young Kim, Tommy Tong, James Waisman, John H. Yim, Behnam Badie, Peter P. Lee
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2017
Materias:	Neoplasms. Tumors. Oncology. Including cancer and carcinogens RC254-282
Acceso en línea:	https://doaj.org/article/88e4e0bed8d344088500b4cc7cf40aed
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spelling	oai:doaj.org-article:88e4e0bed8d344088500b4cc7cf40aed2021-12-02T15:18:47ZHuman brain metastatic stroma attracts breast cancer cells via chemokines CXCL16 and CXCL1210.1038/s41523-017-0008-82374-4677https://doaj.org/article/88e4e0bed8d344088500b4cc7cf40aed2017-03-01T00:00:00Zhttps://doi.org/10.1038/s41523-017-0008-8https://doaj.org/toc/2374-4677Metastasis: brain metastases fuel further spread Breast cancer metastases to the brain secrete signaling molecules that promote additional cancer cells to migrate there. Peter P. Lee and colleagues from the City of Hope in Duarte, California, USA, analyzed protein and gene expression levels in brain metastases, and showed that it is the stromal cells (support cells such as fibroblasts), rather than the cancer cells themselves, that are the source of these homing signals. When compared against stromal cells derived from primary breast tumors or healthy breast tissue, they found that the stromal cells that had lodged themselves in the brain expressed the highest levels of CXCL12 and CXCL16, two chemokines involved in cell movement. Using three-dimensional aggregates, the researchers showed that these metastatic stromal cells promoted cancer cells migration more potently than stromal cells from primary tumors or normal breast tissues. Blocking the chemokine activity or that of its receptor impaired cancer cell movement, suggesting a possible therapeutic strategy for preventing brain metastasis in patients with breast cancer. These results highlight the importance of the tumor microenvironment and stromal cells in the metastasis process of breast cancer.Brile ChungAli A. EsmaeiliSailesh Gopalakrishna-PillaiJohn P. MuradEmily S. AndersenNaveen Kumar ReddyGayathri SrinivasanBrian ArmstrongCaleb ChuYoung KimTommy TongJames WaismanJohn H. YimBehnam BadiePeter P. LeeNature PortfolioarticleNeoplasms. Tumors. Oncology. Including cancer and carcinogensRC254-282ENnpj Breast Cancer, Vol 3, Iss 1, Pp 1-9 (2017)
institution	DOAJ
collection	DOAJ
language	EN
topic	Neoplasms. Tumors. Oncology. Including cancer and carcinogens RC254-282
spellingShingle	Neoplasms. Tumors. Oncology. Including cancer and carcinogens RC254-282 Brile Chung Ali A. Esmaeili Sailesh Gopalakrishna-Pillai John P. Murad Emily S. Andersen Naveen Kumar Reddy Gayathri Srinivasan Brian Armstrong Caleb Chu Young Kim Tommy Tong James Waisman John H. Yim Behnam Badie Peter P. Lee Human brain metastatic stroma attracts breast cancer cells via chemokines CXCL16 and CXCL12
description	Metastasis: brain metastases fuel further spread Breast cancer metastases to the brain secrete signaling molecules that promote additional cancer cells to migrate there. Peter P. Lee and colleagues from the City of Hope in Duarte, California, USA, analyzed protein and gene expression levels in brain metastases, and showed that it is the stromal cells (support cells such as fibroblasts), rather than the cancer cells themselves, that are the source of these homing signals. When compared against stromal cells derived from primary breast tumors or healthy breast tissue, they found that the stromal cells that had lodged themselves in the brain expressed the highest levels of CXCL12 and CXCL16, two chemokines involved in cell movement. Using three-dimensional aggregates, the researchers showed that these metastatic stromal cells promoted cancer cells migration more potently than stromal cells from primary tumors or normal breast tissues. Blocking the chemokine activity or that of its receptor impaired cancer cell movement, suggesting a possible therapeutic strategy for preventing brain metastasis in patients with breast cancer. These results highlight the importance of the tumor microenvironment and stromal cells in the metastasis process of breast cancer.
format	article
author	Brile Chung Ali A. Esmaeili Sailesh Gopalakrishna-Pillai John P. Murad Emily S. Andersen Naveen Kumar Reddy Gayathri Srinivasan Brian Armstrong Caleb Chu Young Kim Tommy Tong James Waisman John H. Yim Behnam Badie Peter P. Lee
author_facet	Brile Chung Ali A. Esmaeili Sailesh Gopalakrishna-Pillai John P. Murad Emily S. Andersen Naveen Kumar Reddy Gayathri Srinivasan Brian Armstrong Caleb Chu Young Kim Tommy Tong James Waisman John H. Yim Behnam Badie Peter P. Lee
author_sort	Brile Chung
title	Human brain metastatic stroma attracts breast cancer cells via chemokines CXCL16 and CXCL12
title_short	Human brain metastatic stroma attracts breast cancer cells via chemokines CXCL16 and CXCL12
title_full	Human brain metastatic stroma attracts breast cancer cells via chemokines CXCL16 and CXCL12
title_fullStr	Human brain metastatic stroma attracts breast cancer cells via chemokines CXCL16 and CXCL12
title_full_unstemmed	Human brain metastatic stroma attracts breast cancer cells via chemokines CXCL16 and CXCL12
title_sort	human brain metastatic stroma attracts breast cancer cells via chemokines cxcl16 and cxcl12
publisher	Nature Portfolio
publishDate	2017
url	https://doaj.org/article/88e4e0bed8d344088500b4cc7cf40aed
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_version_	1718387457792147456

Human brain metastatic stroma attracts breast cancer cells via chemokines CXCL16 and CXCL12

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