Mechanically-sensitive miRNAs bias human mesenchymal stem cell fate via mTOR signalling

Mesenchymal stem cell (MSC) fate can be mechanically regulated by substrate stiffness but this is difficult to control in a 3D hydrogel. Here the authors identify miRNAs that change expression in response to substrate stiffness and RhoA signalling and show that they can bias MSC fate in a 3D soft hy...

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Autores principales:	Jessica E. Frith, Gina D. Kusuma, James Carthew, Fanyi Li, Nicole Cloonan, Guillermo A. Gomez, Justin J. Cooper-White
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2018
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/88e544132d8f42c5b352d66bb7b4f60e
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spelling	oai:doaj.org-article:88e544132d8f42c5b352d66bb7b4f60e2021-12-02T15:33:34ZMechanically-sensitive miRNAs bias human mesenchymal stem cell fate via mTOR signalling10.1038/s41467-017-02486-02041-1723https://doaj.org/article/88e544132d8f42c5b352d66bb7b4f60e2018-01-01T00:00:00Zhttps://doi.org/10.1038/s41467-017-02486-0https://doaj.org/toc/2041-1723Mesenchymal stem cell (MSC) fate can be mechanically regulated by substrate stiffness but this is difficult to control in a 3D hydrogel. Here the authors identify miRNAs that change expression in response to substrate stiffness and RhoA signalling and show that they can bias MSC fate in a 3D soft hydrogel.Jessica E. FrithGina D. KusumaJames CarthewFanyi LiNicole CloonanGuillermo A. GomezJustin J. Cooper-WhiteNature PortfolioarticleScienceQENNature Communications, Vol 9, Iss 1, Pp 1-12 (2018)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Jessica E. Frith Gina D. Kusuma James Carthew Fanyi Li Nicole Cloonan Guillermo A. Gomez Justin J. Cooper-White Mechanically-sensitive miRNAs bias human mesenchymal stem cell fate via mTOR signalling
description	Mesenchymal stem cell (MSC) fate can be mechanically regulated by substrate stiffness but this is difficult to control in a 3D hydrogel. Here the authors identify miRNAs that change expression in response to substrate stiffness and RhoA signalling and show that they can bias MSC fate in a 3D soft hydrogel.
format	article
author	Jessica E. Frith Gina D. Kusuma James Carthew Fanyi Li Nicole Cloonan Guillermo A. Gomez Justin J. Cooper-White
author_facet	Jessica E. Frith Gina D. Kusuma James Carthew Fanyi Li Nicole Cloonan Guillermo A. Gomez Justin J. Cooper-White
author_sort	Jessica E. Frith
title	Mechanically-sensitive miRNAs bias human mesenchymal stem cell fate via mTOR signalling
title_short	Mechanically-sensitive miRNAs bias human mesenchymal stem cell fate via mTOR signalling
title_full	Mechanically-sensitive miRNAs bias human mesenchymal stem cell fate via mTOR signalling
title_fullStr	Mechanically-sensitive miRNAs bias human mesenchymal stem cell fate via mTOR signalling
title_full_unstemmed	Mechanically-sensitive miRNAs bias human mesenchymal stem cell fate via mTOR signalling
title_sort	mechanically-sensitive mirnas bias human mesenchymal stem cell fate via mtor signalling
publisher	Nature Portfolio
publishDate	2018
url	https://doaj.org/article/88e544132d8f42c5b352d66bb7b4f60e
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Mechanically-sensitive miRNAs bias human mesenchymal stem cell fate via mTOR signalling

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