ROLE OF THE REGULATORY T CELLS IN PROGRESSION OF PROSTATE CANCER

The existing data on regulatory T cells (Tregs) in prostate cancer suggest that these cells may penetrate the prostate gland malignant tissue, suppressing antitumor immune response, thus promoting aggressive clinical course and low survival of the cancer patients. Evaluation of T cell subpopulations...

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Autores principales:	S. V. Popov, N. V. Sturov, N. V. Vorobyev, S. V. Khaidukov
Formato:	article
Lenguaje:	RU
Publicado:	SPb RAACI 2019
Materias:	treg cells foxp3 cd127 ctla-4 cytokines prostate cancer Immunologic diseases. Allergy RC581-607
Acceso en línea:	https://doaj.org/article/88e8150524e94347862cc73aed3725bd
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spelling	oai:doaj.org-article:88e8150524e94347862cc73aed3725bd2021-11-18T08:03:48ZROLE OF THE REGULATORY T CELLS IN PROGRESSION OF PROSTATE CANCER1563-06252313-741X10.15789/1563-0625-2019-4-587-594https://doaj.org/article/88e8150524e94347862cc73aed3725bd2019-10-01T00:00:00Zhttps://www.mimmun.ru/mimmun/article/view/1688https://doaj.org/toc/1563-0625https://doaj.org/toc/2313-741XThe existing data on regulatory T cells (Tregs) in prostate cancer suggest that these cells may penetrate the prostate gland malignant tissue, suppressing antitumor immune response, thus promoting aggressive clinical course and low survival of the cancer patients. Evaluation of T cell subpopulations from the tumor microenvironment has shown that the number of CD4+Tregs is associated with inferior clinical prognosis. In particular, each additional CD4+Treg cell has been shown to cause a statistically significant increase in prostate cancer mortality by 12%, regardless of other clinical factors. There are several possible explanations for the increased infiltration of prostate cancer tissue with regulatory T cells. Firstly, malignant cells or tumor-associated macrophages are capable of secreting chemokine CCL22, which has an affinity for the CCR4 receptor expressed on Treg cells. Secondly, cytokines secreted by prostate tumors, such as TGF-β, may regulate the FoxP3 expression, thus expanding the Treg population. TGF-β, in turn, is a multifunctional cytokine that promotes survival and proliferation of transformed cells, including prostate epithelium, as evidenced by increased amounts in the patients with metastatic disease.S. V. PopovN. V. SturovN. V. VorobyevS. V. KhaidukovSPb RAACIarticletreg cellsfoxp3cd127ctla-4cytokinesprostate cancerImmunologic diseases. AllergyRC581-607RUMedicinskaâ Immunologiâ, Vol 21, Iss 4, Pp 587-594 (2019)
institution	DOAJ
collection	DOAJ
language	RU
topic	treg cells foxp3 cd127 ctla-4 cytokines prostate cancer Immunologic diseases. Allergy RC581-607
spellingShingle	treg cells foxp3 cd127 ctla-4 cytokines prostate cancer Immunologic diseases. Allergy RC581-607 S. V. Popov N. V. Sturov N. V. Vorobyev S. V. Khaidukov ROLE OF THE REGULATORY T CELLS IN PROGRESSION OF PROSTATE CANCER
description	The existing data on regulatory T cells (Tregs) in prostate cancer suggest that these cells may penetrate the prostate gland malignant tissue, suppressing antitumor immune response, thus promoting aggressive clinical course and low survival of the cancer patients. Evaluation of T cell subpopulations from the tumor microenvironment has shown that the number of CD4+Tregs is associated with inferior clinical prognosis. In particular, each additional CD4+Treg cell has been shown to cause a statistically significant increase in prostate cancer mortality by 12%, regardless of other clinical factors. There are several possible explanations for the increased infiltration of prostate cancer tissue with regulatory T cells. Firstly, malignant cells or tumor-associated macrophages are capable of secreting chemokine CCL22, which has an affinity for the CCR4 receptor expressed on Treg cells. Secondly, cytokines secreted by prostate tumors, such as TGF-β, may regulate the FoxP3 expression, thus expanding the Treg population. TGF-β, in turn, is a multifunctional cytokine that promotes survival and proliferation of transformed cells, including prostate epithelium, as evidenced by increased amounts in the patients with metastatic disease.
format	article
author	S. V. Popov N. V. Sturov N. V. Vorobyev S. V. Khaidukov
author_facet	S. V. Popov N. V. Sturov N. V. Vorobyev S. V. Khaidukov
author_sort	S. V. Popov
title	ROLE OF THE REGULATORY T CELLS IN PROGRESSION OF PROSTATE CANCER
title_short	ROLE OF THE REGULATORY T CELLS IN PROGRESSION OF PROSTATE CANCER
title_full	ROLE OF THE REGULATORY T CELLS IN PROGRESSION OF PROSTATE CANCER
title_fullStr	ROLE OF THE REGULATORY T CELLS IN PROGRESSION OF PROSTATE CANCER
title_full_unstemmed	ROLE OF THE REGULATORY T CELLS IN PROGRESSION OF PROSTATE CANCER
title_sort	role of the regulatory t cells in progression of prostate cancer
publisher	SPb RAACI
publishDate	2019
url	https://doaj.org/article/88e8150524e94347862cc73aed3725bd
work_keys_str_mv	AT svpopov roleoftheregulatorytcellsinprogressionofprostatecancer AT nvsturov roleoftheregulatorytcellsinprogressionofprostatecancer AT nvvorobyev roleoftheregulatorytcellsinprogressionofprostatecancer AT svkhaidukov roleoftheregulatorytcellsinprogressionofprostatecancer
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ROLE OF THE REGULATORY T CELLS IN PROGRESSION OF PROSTATE CANCER

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