Modeling hepatitis C virus kinetics during liver transplantation reveals the role of the liver in virus clearance

Modeling hepatitis C virus kinetics during liver transplantation reveals the role of the liver in virus clearance

While the liver, specifically hepatocytes, are widely accepted as the main source of hepatitis C virus (HCV) production, the role of the liver/hepatocytes in clearance of circulating HCV remains unknown. Frequent HCV kinetic data were recorded and mathematically modeled from five liver transplant pa...

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Bibliographic Details
Main Authors: Louis Shekhtman, Miquel Navasa, Natasha Sansone, Gonzalo Crespo, Gitanjali Subramanya, Tje Lin Chung, E Fabian Cardozo-Ojeda, Sofía Pérez-del-Pulgar, Alan S Perelson, Scott J Cotler, Xavier Forns, Susan L Uprichard, Harel Dahari
Format: article
Language:EN
Published: eLife Sciences Publications Ltd 2021
Subjects:
hepatitis C virus
viral kinetics
hepatocytes
mathematical modeling
liver transplant
cell culture
Medicine
R
Science
Q
Biology (General)
QH301-705.5
Online Access:https://doaj.org/article/88ec9d007d544a56ba1441581f7bf611
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https://doaj.org/article/88ec9d007d544a56ba1441581f7bf611

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