Nanoparticle-Assisted Sonosensitizers and Their Biomedical Applications

Pengxuan Zhao,1 Youbin Deng,1 Guangya Xiang,2 Yani Liu1 1Department of Medical Ultrasound, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, 430030, People’s Republic of China; 2School of Pharmacy, Tongji Medical College, Huazhong University of Science an...

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Autores principales:	Zhao P, Deng Y, Xiang G, Liu Y
Formato:	article
Lenguaje:	EN
Publicado:	Dove Medical Press 2021
Materias:	sonodynamic therapy sonosensitizers nanoparticles combination therapy Medicine (General) R5-920
Acceso en línea:	https://doaj.org/article/88ee3988fb7c4d49b2d4ddd2721d7ad3
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spelling	oai:doaj.org-article:88ee3988fb7c4d49b2d4ddd2721d7ad32021-12-02T18:47:42ZNanoparticle-Assisted Sonosensitizers and Their Biomedical Applications1178-2013https://doaj.org/article/88ee3988fb7c4d49b2d4ddd2721d7ad32021-07-01T00:00:00Zhttps://www.dovepress.com/nanoparticle-assisted-sonosensitizers-and-their-biomedical-application-peer-reviewed-fulltext-article-IJNhttps://doaj.org/toc/1178-2013Pengxuan Zhao,1 Youbin Deng,1 Guangya Xiang,2 Yani Liu1 1Department of Medical Ultrasound, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, 430030, People’s Republic of China; 2School of Pharmacy, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, 430030, People’s Republic of ChinaCorrespondence: Guangya XiangSchool of Pharmacy, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, 430030, People’s Republic of ChinaEmail youjiti@mails.tjmu.edu.cnYani LiuDepartment of Medical Ultrasound, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, 430030, People’s Republic of ChinaEmail yani.liu@tjh.tjmu.edu.cnAbstract: As a non-invasive strategy, sonodynamic therapy (SDT) which utilizes sonosensitizers to generate reactive oxygen species (ROS) has received significant interest over recent years due to its ability to break depth barrier. However, intrinsic limitations of traditional sonosensitizers hinder the widespread application of SDT. With the development of nanotechnology, various nanoparticles (NPs) have been designed and used to assist sonosensitizers for SDT. This review first summarizes the possible mechanisms of SDT, then classifies the NPs-assisted sonosensitizers and discusses their biomedical applications in ultrasonography, drug delivery, high intensity focused ultrasound and SDT-based combination treatment. Finally, some challenges and future perspectives of NPs-assisted SDT has also been discussed.Keywords: sonodynamic therapy, sonosensitizers, nanoparticles, combination therapyZhao PDeng YXiang GLiu YDove Medical Pressarticlesonodynamic therapysonosensitizersnanoparticlescombination therapyMedicine (General)R5-920ENInternational Journal of Nanomedicine, Vol Volume 16, Pp 4615-4630 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	sonodynamic therapy sonosensitizers nanoparticles combination therapy Medicine (General) R5-920
spellingShingle	sonodynamic therapy sonosensitizers nanoparticles combination therapy Medicine (General) R5-920 Zhao P Deng Y Xiang G Liu Y Nanoparticle-Assisted Sonosensitizers and Their Biomedical Applications
description	Pengxuan Zhao,1 Youbin Deng,1 Guangya Xiang,2 Yani Liu1 1Department of Medical Ultrasound, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, 430030, People’s Republic of China; 2School of Pharmacy, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, 430030, People’s Republic of ChinaCorrespondence: Guangya XiangSchool of Pharmacy, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, 430030, People’s Republic of ChinaEmail youjiti@mails.tjmu.edu.cnYani LiuDepartment of Medical Ultrasound, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, 430030, People’s Republic of ChinaEmail yani.liu@tjh.tjmu.edu.cnAbstract: As a non-invasive strategy, sonodynamic therapy (SDT) which utilizes sonosensitizers to generate reactive oxygen species (ROS) has received significant interest over recent years due to its ability to break depth barrier. However, intrinsic limitations of traditional sonosensitizers hinder the widespread application of SDT. With the development of nanotechnology, various nanoparticles (NPs) have been designed and used to assist sonosensitizers for SDT. This review first summarizes the possible mechanisms of SDT, then classifies the NPs-assisted sonosensitizers and discusses their biomedical applications in ultrasonography, drug delivery, high intensity focused ultrasound and SDT-based combination treatment. Finally, some challenges and future perspectives of NPs-assisted SDT has also been discussed.Keywords: sonodynamic therapy, sonosensitizers, nanoparticles, combination therapy
format	article
author	Zhao P Deng Y Xiang G Liu Y
author_facet	Zhao P Deng Y Xiang G Liu Y
author_sort	Zhao P
title	Nanoparticle-Assisted Sonosensitizers and Their Biomedical Applications
title_short	Nanoparticle-Assisted Sonosensitizers and Their Biomedical Applications
title_full	Nanoparticle-Assisted Sonosensitizers and Their Biomedical Applications
title_fullStr	Nanoparticle-Assisted Sonosensitizers and Their Biomedical Applications
title_full_unstemmed	Nanoparticle-Assisted Sonosensitizers and Their Biomedical Applications
title_sort	nanoparticle-assisted sonosensitizers and their biomedical applications
publisher	Dove Medical Press
publishDate	2021
url	https://doaj.org/article/88ee3988fb7c4d49b2d4ddd2721d7ad3
work_keys_str_mv	AT zhaop nanoparticleassistedsonosensitizersandtheirbiomedicalapplications AT dengy nanoparticleassistedsonosensitizersandtheirbiomedicalapplications AT xiangg nanoparticleassistedsonosensitizersandtheirbiomedicalapplications AT liuy nanoparticleassistedsonosensitizersandtheirbiomedicalapplications
_version_	1718377636333355008

Nanoparticle-Assisted Sonosensitizers and Their Biomedical Applications

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