Ubiquitin receptors are required for substrate-mediated activation of the proteasome’s unfolding ability

Abstract The ubiquitin-proteasome system (UPS) is responsible for the bulk of protein degradation in eukaryotic cells, but the factors that cause different substrates to be unfolded and degraded to different extents are still poorly understood. We previously showed that polyubiquitinated substrates...

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Auteurs principaux: Mary D. Cundiff, Christina M. Hurley, Jeremy D. Wong, Joseph A. Boscia, Aarti Bashyal, Jake Rosenberg, Eden L. Reichard, Nicholas D. Nassif, Jennifer S. Brodbelt, Daniel A. Kraut
Format: article
Langue:EN
Publié: Nature Portfolio 2019
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Accès en ligne:https://doaj.org/article/88efcdeee9f84f3485e5d78c2f85812e
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