Inhibition of CK1ε potentiates the therapeutic efficacy of CDK4/6 inhibitor in breast cancer

Acquisition of CDK4/6i resistance represents a major clinical challenge. Here, the authors report that inhibition of CK1ε can prevent acquisition of CDK4/6i resistance, potentiating the therapeutic efficacy of CDK4/6i in human breast cancer.

Guardado en:

Detalles Bibliográficos
Autores principales:	Fabin Dang, Li Nie, Jin Zhou, Kouhei Shimizu, Chen Chu, Zhong Wu, Anne Fassl, Shizhong Ke, Yuangao Wang, Jinfang Zhang, Tao Zhang, Zhenbo Tu, Hiroyuki Inuzuka, Piotr Sicinski, Adam J. Bass, Wenyi Wei
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/88efe8ceb62e4eb287e6888a694cafe6
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

id	oai:doaj.org-article:88efe8ceb62e4eb287e6888a694cafe6
record_format	dspace
spelling	oai:doaj.org-article:88efe8ceb62e4eb287e6888a694cafe62021-12-02T19:12:27ZInhibition of CK1ε potentiates the therapeutic efficacy of CDK4/6 inhibitor in breast cancer10.1038/s41467-021-25700-62041-1723https://doaj.org/article/88efe8ceb62e4eb287e6888a694cafe62021-09-01T00:00:00Zhttps://doi.org/10.1038/s41467-021-25700-6https://doaj.org/toc/2041-1723Acquisition of CDK4/6i resistance represents a major clinical challenge. Here, the authors report that inhibition of CK1ε can prevent acquisition of CDK4/6i resistance, potentiating the therapeutic efficacy of CDK4/6i in human breast cancer.Fabin DangLi NieJin ZhouKouhei ShimizuChen ChuZhong WuAnne FasslShizhong KeYuangao WangJinfang ZhangTao ZhangZhenbo TuHiroyuki InuzukaPiotr SicinskiAdam J. BassWenyi WeiNature PortfolioarticleScienceQENNature Communications, Vol 12, Iss 1, Pp 1-15 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Fabin Dang Li Nie Jin Zhou Kouhei Shimizu Chen Chu Zhong Wu Anne Fassl Shizhong Ke Yuangao Wang Jinfang Zhang Tao Zhang Zhenbo Tu Hiroyuki Inuzuka Piotr Sicinski Adam J. Bass Wenyi Wei Inhibition of CK1ε potentiates the therapeutic efficacy of CDK4/6 inhibitor in breast cancer
description	Acquisition of CDK4/6i resistance represents a major clinical challenge. Here, the authors report that inhibition of CK1ε can prevent acquisition of CDK4/6i resistance, potentiating the therapeutic efficacy of CDK4/6i in human breast cancer.
format	article
author	Fabin Dang Li Nie Jin Zhou Kouhei Shimizu Chen Chu Zhong Wu Anne Fassl Shizhong Ke Yuangao Wang Jinfang Zhang Tao Zhang Zhenbo Tu Hiroyuki Inuzuka Piotr Sicinski Adam J. Bass Wenyi Wei
author_facet	Fabin Dang Li Nie Jin Zhou Kouhei Shimizu Chen Chu Zhong Wu Anne Fassl Shizhong Ke Yuangao Wang Jinfang Zhang Tao Zhang Zhenbo Tu Hiroyuki Inuzuka Piotr Sicinski Adam J. Bass Wenyi Wei
author_sort	Fabin Dang
title	Inhibition of CK1ε potentiates the therapeutic efficacy of CDK4/6 inhibitor in breast cancer
title_short	Inhibition of CK1ε potentiates the therapeutic efficacy of CDK4/6 inhibitor in breast cancer
title_full	Inhibition of CK1ε potentiates the therapeutic efficacy of CDK4/6 inhibitor in breast cancer
title_fullStr	Inhibition of CK1ε potentiates the therapeutic efficacy of CDK4/6 inhibitor in breast cancer
title_full_unstemmed	Inhibition of CK1ε potentiates the therapeutic efficacy of CDK4/6 inhibitor in breast cancer
title_sort	inhibition of ck1ε potentiates the therapeutic efficacy of cdk4/6 inhibitor in breast cancer
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/88efe8ceb62e4eb287e6888a694cafe6
work_keys_str_mv	AT fabindang inhibitionofck1epotentiatesthetherapeuticefficacyofcdk46inhibitorinbreastcancer AT linie inhibitionofck1epotentiatesthetherapeuticefficacyofcdk46inhibitorinbreastcancer AT jinzhou inhibitionofck1epotentiatesthetherapeuticefficacyofcdk46inhibitorinbreastcancer AT kouheishimizu inhibitionofck1epotentiatesthetherapeuticefficacyofcdk46inhibitorinbreastcancer AT chenchu inhibitionofck1epotentiatesthetherapeuticefficacyofcdk46inhibitorinbreastcancer AT zhongwu inhibitionofck1epotentiatesthetherapeuticefficacyofcdk46inhibitorinbreastcancer AT annefassl inhibitionofck1epotentiatesthetherapeuticefficacyofcdk46inhibitorinbreastcancer AT shizhongke inhibitionofck1epotentiatesthetherapeuticefficacyofcdk46inhibitorinbreastcancer AT yuangaowang inhibitionofck1epotentiatesthetherapeuticefficacyofcdk46inhibitorinbreastcancer AT jinfangzhang inhibitionofck1epotentiatesthetherapeuticefficacyofcdk46inhibitorinbreastcancer AT taozhang inhibitionofck1epotentiatesthetherapeuticefficacyofcdk46inhibitorinbreastcancer AT zhenbotu inhibitionofck1epotentiatesthetherapeuticefficacyofcdk46inhibitorinbreastcancer AT hiroyukiinuzuka inhibitionofck1epotentiatesthetherapeuticefficacyofcdk46inhibitorinbreastcancer AT piotrsicinski inhibitionofck1epotentiatesthetherapeuticefficacyofcdk46inhibitorinbreastcancer AT adamjbass inhibitionofck1epotentiatesthetherapeuticefficacyofcdk46inhibitorinbreastcancer AT wenyiwei inhibitionofck1epotentiatesthetherapeuticefficacyofcdk46inhibitorinbreastcancer
_version_	1718377054174445568

Inhibition of CK1ε potentiates the therapeutic efficacy of CDK4/6 inhibitor in breast cancer

Ejemplares similares