Atomic-level insight into mRNA processing bodies by combining solid and solution-state NMR spectroscopy

Processing bodies are membrane less organelles that contain enzymes involved in mRNA turnover, among them enhancer of decapping 3 (Edc3). Here the authors use solid- and solution-state NMR spectroscopy to characterize the structural organization and dynamics of Edc3 and find that its interactions wi...

Descripción completa

Guardado en:

Detalles Bibliográficos
Autores principales:	Reinier Damman, Stefan Schütz, Yanzhang Luo, Markus Weingarth, Remco Sprangers, Marc Baldus
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2019
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/88f45dbd4d524888a10d239400a14535
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

id	oai:doaj.org-article:88f45dbd4d524888a10d239400a14535
record_format	dspace
spelling	oai:doaj.org-article:88f45dbd4d524888a10d239400a145352021-12-02T16:58:01ZAtomic-level insight into mRNA processing bodies by combining solid and solution-state NMR spectroscopy10.1038/s41467-019-12402-32041-1723https://doaj.org/article/88f45dbd4d524888a10d239400a145352019-10-01T00:00:00Zhttps://doi.org/10.1038/s41467-019-12402-3https://doaj.org/toc/2041-1723Processing bodies are membrane less organelles that contain enzymes involved in mRNA turnover, among them enhancer of decapping 3 (Edc3). Here the authors use solid- and solution-state NMR spectroscopy to characterize the structural organization and dynamics of Edc3 and find that its interactions with RNA and between the different Edc3 domains are largely preserved in the phase-separated state.Reinier DammanStefan SchützYanzhang LuoMarkus WeingarthRemco SprangersMarc BaldusNature PortfolioarticleScienceQENNature Communications, Vol 10, Iss 1, Pp 1-11 (2019)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Reinier Damman Stefan Schütz Yanzhang Luo Markus Weingarth Remco Sprangers Marc Baldus Atomic-level insight into mRNA processing bodies by combining solid and solution-state NMR spectroscopy
description	Processing bodies are membrane less organelles that contain enzymes involved in mRNA turnover, among them enhancer of decapping 3 (Edc3). Here the authors use solid- and solution-state NMR spectroscopy to characterize the structural organization and dynamics of Edc3 and find that its interactions with RNA and between the different Edc3 domains are largely preserved in the phase-separated state.
format	article
author	Reinier Damman Stefan Schütz Yanzhang Luo Markus Weingarth Remco Sprangers Marc Baldus
author_facet	Reinier Damman Stefan Schütz Yanzhang Luo Markus Weingarth Remco Sprangers Marc Baldus
author_sort	Reinier Damman
title	Atomic-level insight into mRNA processing bodies by combining solid and solution-state NMR spectroscopy
title_short	Atomic-level insight into mRNA processing bodies by combining solid and solution-state NMR spectroscopy
title_full	Atomic-level insight into mRNA processing bodies by combining solid and solution-state NMR spectroscopy
title_fullStr	Atomic-level insight into mRNA processing bodies by combining solid and solution-state NMR spectroscopy
title_full_unstemmed	Atomic-level insight into mRNA processing bodies by combining solid and solution-state NMR spectroscopy
title_sort	atomic-level insight into mrna processing bodies by combining solid and solution-state nmr spectroscopy
publisher	Nature Portfolio
publishDate	2019
url	https://doaj.org/article/88f45dbd4d524888a10d239400a14535
work_keys_str_mv	AT reinierdamman atomiclevelinsightintomrnaprocessingbodiesbycombiningsolidandsolutionstatenmrspectroscopy AT stefanschutz atomiclevelinsightintomrnaprocessingbodiesbycombiningsolidandsolutionstatenmrspectroscopy AT yanzhangluo atomiclevelinsightintomrnaprocessingbodiesbycombiningsolidandsolutionstatenmrspectroscopy AT markusweingarth atomiclevelinsightintomrnaprocessingbodiesbycombiningsolidandsolutionstatenmrspectroscopy AT remcosprangers atomiclevelinsightintomrnaprocessingbodiesbycombiningsolidandsolutionstatenmrspectroscopy AT marcbaldus atomiclevelinsightintomrnaprocessingbodiesbycombiningsolidandsolutionstatenmrspectroscopy
_version_	1718382398313332736

Atomic-level insight into mRNA processing bodies by combining solid and solution-state NMR spectroscopy

Ejemplares similares