PUMA gene delivery to synoviocytes reduces inflammation and degeneration of arthritic joints

Proliferation of synoviocytes contributes to joint damage in rheumatoid arthritis. Here the authors show that targeting of these cells by a vector, consisting of a baculovirus conjugated to an adenovirus carrying the pro-apoptotic gene PUMA, has therapeutic efficacy in a rat arthritis model.

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Detalles Bibliográficos
Autores principales: Saw-See Hong, Hubert Marotte, Guillaume Courbon, Gary S. Firestein, Pierre Boulanger, Pierre Miossec
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2017
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Acceso en línea:https://doaj.org/article/88f69cca0bc14b8abdae60547d936af1
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Descripción
Sumario:Proliferation of synoviocytes contributes to joint damage in rheumatoid arthritis. Here the authors show that targeting of these cells by a vector, consisting of a baculovirus conjugated to an adenovirus carrying the pro-apoptotic gene PUMA, has therapeutic efficacy in a rat arthritis model.