PUMA gene delivery to synoviocytes reduces inflammation and degeneration of arthritic joints

Proliferation of synoviocytes contributes to joint damage in rheumatoid arthritis. Here the authors show that targeting of these cells by a vector, consisting of a baculovirus conjugated to an adenovirus carrying the pro-apoptotic gene PUMA, has therapeutic efficacy in a rat arthritis model.

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Autores principales:	Saw-See Hong, Hubert Marotte, Guillaume Courbon, Gary S. Firestein, Pierre Boulanger, Pierre Miossec
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2017
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/88f69cca0bc14b8abdae60547d936af1
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spelling	oai:doaj.org-article:88f69cca0bc14b8abdae60547d936af12021-12-02T10:47:59ZPUMA gene delivery to synoviocytes reduces inflammation and degeneration of arthritic joints10.1038/s41467-017-00142-12041-1723https://doaj.org/article/88f69cca0bc14b8abdae60547d936af12017-07-01T00:00:00Zhttps://doi.org/10.1038/s41467-017-00142-1https://doaj.org/toc/2041-1723Proliferation of synoviocytes contributes to joint damage in rheumatoid arthritis. Here the authors show that targeting of these cells by a vector, consisting of a baculovirus conjugated to an adenovirus carrying the pro-apoptotic gene PUMA, has therapeutic efficacy in a rat arthritis model.Saw-See HongHubert MarotteGuillaume CourbonGary S. FiresteinPierre BoulangerPierre MiossecNature PortfolioarticleScienceQENNature Communications, Vol 8, Iss 1, Pp 1-12 (2017)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Saw-See Hong Hubert Marotte Guillaume Courbon Gary S. Firestein Pierre Boulanger Pierre Miossec PUMA gene delivery to synoviocytes reduces inflammation and degeneration of arthritic joints
description	Proliferation of synoviocytes contributes to joint damage in rheumatoid arthritis. Here the authors show that targeting of these cells by a vector, consisting of a baculovirus conjugated to an adenovirus carrying the pro-apoptotic gene PUMA, has therapeutic efficacy in a rat arthritis model.
format	article
author	Saw-See Hong Hubert Marotte Guillaume Courbon Gary S. Firestein Pierre Boulanger Pierre Miossec
author_facet	Saw-See Hong Hubert Marotte Guillaume Courbon Gary S. Firestein Pierre Boulanger Pierre Miossec
author_sort	Saw-See Hong
title	PUMA gene delivery to synoviocytes reduces inflammation and degeneration of arthritic joints
title_short	PUMA gene delivery to synoviocytes reduces inflammation and degeneration of arthritic joints
title_full	PUMA gene delivery to synoviocytes reduces inflammation and degeneration of arthritic joints
title_fullStr	PUMA gene delivery to synoviocytes reduces inflammation and degeneration of arthritic joints
title_full_unstemmed	PUMA gene delivery to synoviocytes reduces inflammation and degeneration of arthritic joints
title_sort	puma gene delivery to synoviocytes reduces inflammation and degeneration of arthritic joints
publisher	Nature Portfolio
publishDate	2017
url	https://doaj.org/article/88f69cca0bc14b8abdae60547d936af1
work_keys_str_mv	AT sawseehong pumagenedeliverytosynoviocytesreducesinflammationanddegenerationofarthriticjoints AT hubertmarotte pumagenedeliverytosynoviocytesreducesinflammationanddegenerationofarthriticjoints AT guillaumecourbon pumagenedeliverytosynoviocytesreducesinflammationanddegenerationofarthriticjoints AT garysfirestein pumagenedeliverytosynoviocytesreducesinflammationanddegenerationofarthriticjoints AT pierreboulanger pumagenedeliverytosynoviocytesreducesinflammationanddegenerationofarthriticjoints AT pierremiossec pumagenedeliverytosynoviocytesreducesinflammationanddegenerationofarthriticjoints
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PUMA gene delivery to synoviocytes reduces inflammation and degeneration of arthritic joints

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