Visual gamma oscillations predict sensory sensitivity in females as they do in males

Abstract Gamma oscillations are driven by local cortical excitatory (E)–inhibitory (I) loops and may help to characterize neural processing involving excitatory-inhibitory interactions. In the visual cortex reliable gamma oscillations can be recorded with magnetoencephalography (MEG) in the majority...

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Autores principales:	Viktoriya O. Manyukhina, Ekaterina N. Rostovtseva, Andrey O. Prokofyev, Tatiana S. Obukhova, Justin F. Schneiderman, Tatiana A. Stroganova, Elena V. Orekhova
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/88fc478fae754057a910454f59378ae6
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spelling	oai:doaj.org-article:88fc478fae754057a910454f59378ae62021-12-02T17:34:35ZVisual gamma oscillations predict sensory sensitivity in females as they do in males10.1038/s41598-021-91381-22045-2322https://doaj.org/article/88fc478fae754057a910454f59378ae62021-06-01T00:00:00Zhttps://doi.org/10.1038/s41598-021-91381-2https://doaj.org/toc/2045-2322Abstract Gamma oscillations are driven by local cortical excitatory (E)–inhibitory (I) loops and may help to characterize neural processing involving excitatory-inhibitory interactions. In the visual cortex reliable gamma oscillations can be recorded with magnetoencephalography (MEG) in the majority of individuals, which makes visual gamma an attractive candidate for biomarkers of brain disorders associated with E/I imbalance. Little is known, however, about if/how these oscillations reflect individual differences in neural excitability and associated sensory/perceptual phenomena. The power of visual gamma response (GR) changes nonlinearly with increasing stimulation intensity: it increases with transition from static to slowly drifting high-contrast grating and then attenuates with further increase in the drift rate. In a recent MEG study we found that the GR attenuation predicted sensitivity to sensory stimuli in everyday life in neurotypical adult men and in men with autism spectrum disorders. Here, we replicated these results in neurotypical female participants. The GR enhancement with transition from static to slowly drifting grating did not correlate significantly with the sensory sensitivity measures. These findings suggest that weak velocity-related attenuation of the GR is a reliable neural concomitant of visual hypersensitivity and that the degree of GR attenuation may provide useful information about E/I balance in the visual cortex.Viktoriya O. ManyukhinaEkaterina N. RostovtsevaAndrey O. ProkofyevTatiana S. ObukhovaJustin F. SchneidermanTatiana A. StroganovaElena V. OrekhovaNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 11, Iss 1, Pp 1-10 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Viktoriya O. Manyukhina Ekaterina N. Rostovtseva Andrey O. Prokofyev Tatiana S. Obukhova Justin F. Schneiderman Tatiana A. Stroganova Elena V. Orekhova Visual gamma oscillations predict sensory sensitivity in females as they do in males
description	Abstract Gamma oscillations are driven by local cortical excitatory (E)–inhibitory (I) loops and may help to characterize neural processing involving excitatory-inhibitory interactions. In the visual cortex reliable gamma oscillations can be recorded with magnetoencephalography (MEG) in the majority of individuals, which makes visual gamma an attractive candidate for biomarkers of brain disorders associated with E/I imbalance. Little is known, however, about if/how these oscillations reflect individual differences in neural excitability and associated sensory/perceptual phenomena. The power of visual gamma response (GR) changes nonlinearly with increasing stimulation intensity: it increases with transition from static to slowly drifting high-contrast grating and then attenuates with further increase in the drift rate. In a recent MEG study we found that the GR attenuation predicted sensitivity to sensory stimuli in everyday life in neurotypical adult men and in men with autism spectrum disorders. Here, we replicated these results in neurotypical female participants. The GR enhancement with transition from static to slowly drifting grating did not correlate significantly with the sensory sensitivity measures. These findings suggest that weak velocity-related attenuation of the GR is a reliable neural concomitant of visual hypersensitivity and that the degree of GR attenuation may provide useful information about E/I balance in the visual cortex.
format	article
author	Viktoriya O. Manyukhina Ekaterina N. Rostovtseva Andrey O. Prokofyev Tatiana S. Obukhova Justin F. Schneiderman Tatiana A. Stroganova Elena V. Orekhova
author_facet	Viktoriya O. Manyukhina Ekaterina N. Rostovtseva Andrey O. Prokofyev Tatiana S. Obukhova Justin F. Schneiderman Tatiana A. Stroganova Elena V. Orekhova
author_sort	Viktoriya O. Manyukhina
title	Visual gamma oscillations predict sensory sensitivity in females as they do in males
title_short	Visual gamma oscillations predict sensory sensitivity in females as they do in males
title_full	Visual gamma oscillations predict sensory sensitivity in females as they do in males
title_fullStr	Visual gamma oscillations predict sensory sensitivity in females as they do in males
title_full_unstemmed	Visual gamma oscillations predict sensory sensitivity in females as they do in males
title_sort	visual gamma oscillations predict sensory sensitivity in females as they do in males
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/88fc478fae754057a910454f59378ae6
work_keys_str_mv	AT viktoriyaomanyukhina visualgammaoscillationspredictsensorysensitivityinfemalesastheydoinmales AT ekaterinanrostovtseva visualgammaoscillationspredictsensorysensitivityinfemalesastheydoinmales AT andreyoprokofyev visualgammaoscillationspredictsensorysensitivityinfemalesastheydoinmales AT tatianasobukhova visualgammaoscillationspredictsensorysensitivityinfemalesastheydoinmales AT justinfschneiderman visualgammaoscillationspredictsensorysensitivityinfemalesastheydoinmales AT tatianaastroganova visualgammaoscillationspredictsensorysensitivityinfemalesastheydoinmales AT elenavorekhova visualgammaoscillationspredictsensorysensitivityinfemalesastheydoinmales
_version_	1718379951856549888

Visual gamma oscillations predict sensory sensitivity in females as they do in males

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