Pathophysiological concepts in mild traumatic brain injury: diffusion tensor imaging related to acute perfusion CT imaging.

<h4>Background</h4>A subgroup of patients with mild traumatic brain injury (TBI) experiences residual symptoms interfering with their return to work. The pathophysiological substrate of the suboptimal outcome in these patients is a source of debate.<h4>Objective</h4>To provid...

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Autores principales:	Zwany Metting, Leonardo Cerliani, Lars A Rödiger, Joukje van der Naalt
Formato:	article
Lenguaje:	EN
Publicado:	Public Library of Science (PLoS) 2013
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/88fd644e98a4401f9f5c58e0a4e2bbdc
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spelling	oai:doaj.org-article:88fd644e98a4401f9f5c58e0a4e2bbdc2021-11-18T07:44:59ZPathophysiological concepts in mild traumatic brain injury: diffusion tensor imaging related to acute perfusion CT imaging.1932-620310.1371/journal.pone.0064461https://doaj.org/article/88fd644e98a4401f9f5c58e0a4e2bbdc2013-01-01T00:00:00Zhttps://www.ncbi.nlm.nih.gov/pmc/articles/pmid/23704986/?tool=EBIhttps://doaj.org/toc/1932-6203<h4>Background</h4>A subgroup of patients with mild traumatic brain injury (TBI) experiences residual symptoms interfering with their return to work. The pathophysiological substrate of the suboptimal outcome in these patients is a source of debate.<h4>Objective</h4>To provide greater insight into the pathophysiological mechanisms of mild TBI.<h4>Methods</h4>Diffusion tensor imaging (DTI) was performed during follow-up of 18 patients with mild TBI and compared with healthy control subjects. DTI data of the patient group were also compared with perfusion CT imaging in the acute phase of injury.<h4>Results</h4>In patients with mild TBI, a trend was observed for a decreased fractional anisotropy (FA) in widespread bilateral frontal white matter areas with increased mean diffusivity (MD) in the parieto-temporal regions, compared to healthy control subjects. Cerebral blood volume (CBV) correlated significantly with FA in several white matter tracts including the corpus callosum, the internal capsule, the inferior fronto-occipital fascicle, the corticospinal tract, the superior and the inferior longitudinal fascicle.<h4>Conclusion</h4>In mild TBI with normal conventional imaging significant associations between cerebral perfusion in the acute phase of injury and DTI analyses in the chronic phase of injury were discerned. The pathophysiological concept of these findings is being outlined.Zwany MettingLeonardo CerlianiLars A RödigerJoukje van der NaaltPublic Library of Science (PLoS)articleMedicineRScienceQENPLoS ONE, Vol 8, Iss 5, p e64461 (2013)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Zwany Metting Leonardo Cerliani Lars A Rödiger Joukje van der Naalt Pathophysiological concepts in mild traumatic brain injury: diffusion tensor imaging related to acute perfusion CT imaging.
description	<h4>Background</h4>A subgroup of patients with mild traumatic brain injury (TBI) experiences residual symptoms interfering with their return to work. The pathophysiological substrate of the suboptimal outcome in these patients is a source of debate.<h4>Objective</h4>To provide greater insight into the pathophysiological mechanisms of mild TBI.<h4>Methods</h4>Diffusion tensor imaging (DTI) was performed during follow-up of 18 patients with mild TBI and compared with healthy control subjects. DTI data of the patient group were also compared with perfusion CT imaging in the acute phase of injury.<h4>Results</h4>In patients with mild TBI, a trend was observed for a decreased fractional anisotropy (FA) in widespread bilateral frontal white matter areas with increased mean diffusivity (MD) in the parieto-temporal regions, compared to healthy control subjects. Cerebral blood volume (CBV) correlated significantly with FA in several white matter tracts including the corpus callosum, the internal capsule, the inferior fronto-occipital fascicle, the corticospinal tract, the superior and the inferior longitudinal fascicle.<h4>Conclusion</h4>In mild TBI with normal conventional imaging significant associations between cerebral perfusion in the acute phase of injury and DTI analyses in the chronic phase of injury were discerned. The pathophysiological concept of these findings is being outlined.
format	article
author	Zwany Metting Leonardo Cerliani Lars A Rödiger Joukje van der Naalt
author_facet	Zwany Metting Leonardo Cerliani Lars A Rödiger Joukje van der Naalt
author_sort	Zwany Metting
title	Pathophysiological concepts in mild traumatic brain injury: diffusion tensor imaging related to acute perfusion CT imaging.
title_short	Pathophysiological concepts in mild traumatic brain injury: diffusion tensor imaging related to acute perfusion CT imaging.
title_full	Pathophysiological concepts in mild traumatic brain injury: diffusion tensor imaging related to acute perfusion CT imaging.
title_fullStr	Pathophysiological concepts in mild traumatic brain injury: diffusion tensor imaging related to acute perfusion CT imaging.
title_full_unstemmed	Pathophysiological concepts in mild traumatic brain injury: diffusion tensor imaging related to acute perfusion CT imaging.
title_sort	pathophysiological concepts in mild traumatic brain injury: diffusion tensor imaging related to acute perfusion ct imaging.
publisher	Public Library of Science (PLoS)
publishDate	2013
url	https://doaj.org/article/88fd644e98a4401f9f5c58e0a4e2bbdc
work_keys_str_mv	AT zwanymetting pathophysiologicalconceptsinmildtraumaticbraininjurydiffusiontensorimagingrelatedtoacuteperfusionctimaging AT leonardocerliani pathophysiologicalconceptsinmildtraumaticbraininjurydiffusiontensorimagingrelatedtoacuteperfusionctimaging AT larsarodiger pathophysiologicalconceptsinmildtraumaticbraininjurydiffusiontensorimagingrelatedtoacuteperfusionctimaging AT joukjevandernaalt pathophysiologicalconceptsinmildtraumaticbraininjurydiffusiontensorimagingrelatedtoacuteperfusionctimaging
_version_	1718423047980974080

Pathophysiological concepts in mild traumatic brain injury: diffusion tensor imaging related to acute perfusion CT imaging.

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