Therapeutic targets of hypercholesterolemia: HMGCR and LDLR

Shizhan Ma,1,2 Wenxiu Sun,3 Ling Gao,1,4,5 Shudong Liu61Department of Endocrinology and Metabolism, Shandong Provincial Hospital Affiliated to Shandong First Medical University, Jinan 250021, People’s Republic of China; 2Department of Endocrinology and Metabolism, Shandong Provincial Hospi...

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Autores principales:	Ma S, Sun W, Gao L, Liu S
Formato:	article
Lenguaje:	EN
Publicado:	Dove Medical Press 2019
Materias:	Cholesterol homeostasis CVD HMGCR LDLR; Specialties of internal medicine RC581-951
Acceso en línea:	https://doaj.org/article/890045ebd0fe4acaa92cd746c3274381
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spelling	oai:doaj.org-article:890045ebd0fe4acaa92cd746c32743812021-12-02T06:53:37ZTherapeutic targets of hypercholesterolemia: HMGCR and LDLR1178-7007https://doaj.org/article/890045ebd0fe4acaa92cd746c32743812019-08-01T00:00:00Zhttps://www.dovepress.com/therapeutic-targets-of-hypercholesterolemia-hmgcr-and-ldlr-peer-reviewed-article-DMSOhttps://doaj.org/toc/1178-7007Shizhan Ma,1,2 Wenxiu Sun,3 Ling Gao,1,4,5 Shudong Liu61Department of Endocrinology and Metabolism, Shandong Provincial Hospital Affiliated to Shandong First Medical University, Jinan 250021, People’s Republic of China; 2Department of Endocrinology and Metabolism, Shandong Provincial Hospital Affiliated to Shandong University, Jinan 250021, People’s Republic of China; 3Department of Pharmacy, Taishan Vocational College of Nursing, Taian 271000, People’s Republic of China; 4Scientific Center, Shandong Provincial Hospital Affiliated to Shandong First Medical University, Jinan 250021, People’s Republic of China; 5Scientific Center, Shandong Provincial Hospital Affiliated to Shandong University, Jinan 250021, People’s Republic of China; 6Department of Endocrinology, Shandong Rongjun General Hospital, Jinan 250013, People’s Republic of ChinaCorrespondence: Ling GaoScientific Center, Shandong Provincial Hospital Affiliated to Shandong University, 324 Jing 5 Road, Jinan, Shandong Province 250021, People’s Republic of ChinaTel +86 531 6877 6910Email gaoling1@medmail.com.cnShudong LiuDepartment of Endocrinology, Shandong Rongjun General Hospital, 23 Jiefang Road, Jinan, Shandong Province 250013, People’s Republic of ChinaTel +86 531 8238 2351Email lsd008@126.comAbstract: Cholesterol homeostasis is critical and necessary for the body’s functions. Hypercholesterolemia can lead to significant clinical problems, such as cardiovascular disease (CVD). 3-Hydroxy-3-methylglutaryl coenzyme A reductase (HMGCR) and low–density lipoprotein cholesterol receptor (LDLR) are major points of control in cholesterol homeostasis. We summarize the regulatory mechanisms of HMGCR and LDLR, which may provide insight for new drug design and development.Keywords: cholesterol homeostasis, CVD, HMGCR, LDLRMa SSun WGao LLiu SDove Medical PressarticleCholesterol homeostasisCVDHMGCRLDLR;Specialties of internal medicineRC581-951ENDiabetes, Metabolic Syndrome and Obesity: Targets and Therapy, Vol Volume 12, Pp 1543-1553 (2019)
institution	DOAJ
collection	DOAJ
language	EN
topic	Cholesterol homeostasis CVD HMGCR LDLR; Specialties of internal medicine RC581-951
spellingShingle	Cholesterol homeostasis CVD HMGCR LDLR; Specialties of internal medicine RC581-951 Ma S Sun W Gao L Liu S Therapeutic targets of hypercholesterolemia: HMGCR and LDLR
description	Shizhan Ma,1,2 Wenxiu Sun,3 Ling Gao,1,4,5 Shudong Liu61Department of Endocrinology and Metabolism, Shandong Provincial Hospital Affiliated to Shandong First Medical University, Jinan 250021, People’s Republic of China; 2Department of Endocrinology and Metabolism, Shandong Provincial Hospital Affiliated to Shandong University, Jinan 250021, People’s Republic of China; 3Department of Pharmacy, Taishan Vocational College of Nursing, Taian 271000, People’s Republic of China; 4Scientific Center, Shandong Provincial Hospital Affiliated to Shandong First Medical University, Jinan 250021, People’s Republic of China; 5Scientific Center, Shandong Provincial Hospital Affiliated to Shandong University, Jinan 250021, People’s Republic of China; 6Department of Endocrinology, Shandong Rongjun General Hospital, Jinan 250013, People’s Republic of ChinaCorrespondence: Ling GaoScientific Center, Shandong Provincial Hospital Affiliated to Shandong University, 324 Jing 5 Road, Jinan, Shandong Province 250021, People’s Republic of ChinaTel +86 531 6877 6910Email gaoling1@medmail.com.cnShudong LiuDepartment of Endocrinology, Shandong Rongjun General Hospital, 23 Jiefang Road, Jinan, Shandong Province 250013, People’s Republic of ChinaTel +86 531 8238 2351Email lsd008@126.comAbstract: Cholesterol homeostasis is critical and necessary for the body’s functions. Hypercholesterolemia can lead to significant clinical problems, such as cardiovascular disease (CVD). 3-Hydroxy-3-methylglutaryl coenzyme A reductase (HMGCR) and low–density lipoprotein cholesterol receptor (LDLR) are major points of control in cholesterol homeostasis. We summarize the regulatory mechanisms of HMGCR and LDLR, which may provide insight for new drug design and development.Keywords: cholesterol homeostasis, CVD, HMGCR, LDLR
format	article
author	Ma S Sun W Gao L Liu S
author_facet	Ma S Sun W Gao L Liu S
author_sort	Ma S
title	Therapeutic targets of hypercholesterolemia: HMGCR and LDLR
title_short	Therapeutic targets of hypercholesterolemia: HMGCR and LDLR
title_full	Therapeutic targets of hypercholesterolemia: HMGCR and LDLR
title_fullStr	Therapeutic targets of hypercholesterolemia: HMGCR and LDLR
title_full_unstemmed	Therapeutic targets of hypercholesterolemia: HMGCR and LDLR
title_sort	therapeutic targets of hypercholesterolemia: hmgcr and ldlr
publisher	Dove Medical Press
publishDate	2019
url	https://doaj.org/article/890045ebd0fe4acaa92cd746c3274381
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Therapeutic targets of hypercholesterolemia: HMGCR and LDLR

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