A Simple Queuing Model for Molecular Communications Receivers

The complexity of molecular communications system, involving a massive number of interacting entities, makes scalability a fundamental property of simulators and modeling tools. A typical scenario is that of targeted drug delivery systems, which makes use of biological nanomachines close to a biolog...

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Autores principales:	Mauro Femminella, Gianluca Reali
Formato:	article
Lenguaje:	EN
Publicado:	MDPI AG 2021
Materias:	molecular communications diffusion markovian model scalable simulation Chemical technology TP1-1185
Acceso en línea:	https://doaj.org/article/8903e9e03f5f4b24a708a201acbdf35f
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spelling	oai:doaj.org-article:8903e9e03f5f4b24a708a201acbdf35f2021-11-25T18:58:27ZA Simple Queuing Model for Molecular Communications Receivers10.3390/s212276641424-8220https://doaj.org/article/8903e9e03f5f4b24a708a201acbdf35f2021-11-01T00:00:00Zhttps://www.mdpi.com/1424-8220/21/22/7664https://doaj.org/toc/1424-8220The complexity of molecular communications system, involving a massive number of interacting entities, makes scalability a fundamental property of simulators and modeling tools. A typical scenario is that of targeted drug delivery systems, which makes use of biological nanomachines close to a biological target, able to release molecules in the diseased area. In this paper, we propose a simple but reliable receiver model for diffusion-based molecular communication systems tackling the time needed for analyzing such a system. The proposed model consists of using an equivalent markovian queuing model, which reproduces the aggregate behavior of thousands of receptors spread over the receiver surface. It takes into account not only the fact that the absorption of molecules can occur only through receptors, but also that absorption is not an instantaneous process and may require a significant time during which the receptor is not available to bind to other molecules. Our results, expressed in terms of number of absorbed molecules and average number of busy receptors, demonstrate that the proposed approach is in good agreement with results obtained through particle-based simulations of a large number of receptors, although the time taken for obtaining the results with the proposed model is an order of magnitudes lower than the simulation time. We believe that this model can be the precursor of novel class of models based on similar principles that allow realizing reliable simulations of much larger systems.Mauro FemminellaGianluca RealiMDPI AGarticlemolecular communicationsdiffusionmarkovian modelscalable simulationChemical technologyTP1-1185ENSensors, Vol 21, Iss 7664, p 7664 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	molecular communications diffusion markovian model scalable simulation Chemical technology TP1-1185
spellingShingle	molecular communications diffusion markovian model scalable simulation Chemical technology TP1-1185 Mauro Femminella Gianluca Reali A Simple Queuing Model for Molecular Communications Receivers
description	The complexity of molecular communications system, involving a massive number of interacting entities, makes scalability a fundamental property of simulators and modeling tools. A typical scenario is that of targeted drug delivery systems, which makes use of biological nanomachines close to a biological target, able to release molecules in the diseased area. In this paper, we propose a simple but reliable receiver model for diffusion-based molecular communication systems tackling the time needed for analyzing such a system. The proposed model consists of using an equivalent markovian queuing model, which reproduces the aggregate behavior of thousands of receptors spread over the receiver surface. It takes into account not only the fact that the absorption of molecules can occur only through receptors, but also that absorption is not an instantaneous process and may require a significant time during which the receptor is not available to bind to other molecules. Our results, expressed in terms of number of absorbed molecules and average number of busy receptors, demonstrate that the proposed approach is in good agreement with results obtained through particle-based simulations of a large number of receptors, although the time taken for obtaining the results with the proposed model is an order of magnitudes lower than the simulation time. We believe that this model can be the precursor of novel class of models based on similar principles that allow realizing reliable simulations of much larger systems.
format	article
author	Mauro Femminella Gianluca Reali
author_facet	Mauro Femminella Gianluca Reali
author_sort	Mauro Femminella
title	A Simple Queuing Model for Molecular Communications Receivers
title_short	A Simple Queuing Model for Molecular Communications Receivers
title_full	A Simple Queuing Model for Molecular Communications Receivers
title_fullStr	A Simple Queuing Model for Molecular Communications Receivers
title_full_unstemmed	A Simple Queuing Model for Molecular Communications Receivers
title_sort	simple queuing model for molecular communications receivers
publisher	MDPI AG
publishDate	2021
url	https://doaj.org/article/8903e9e03f5f4b24a708a201acbdf35f
work_keys_str_mv	AT maurofemminella asimplequeuingmodelformolecularcommunicationsreceivers AT gianlucareali asimplequeuingmodelformolecularcommunicationsreceivers AT maurofemminella simplequeuingmodelformolecularcommunicationsreceivers AT gianlucareali simplequeuingmodelformolecularcommunicationsreceivers
_version_	1718410474227236864

A Simple Queuing Model for Molecular Communications Receivers

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