Lysosomal integral membrane protein-2 as a phospholipid receptor revealed by biophysical and cellular studies

Lysosomal integral membrane protein-2 (LIMP-2) is a glucocerebrosidase receptor, which is linked to kidney failure and other diseases. Here the authors show that LIMP-2 is also a phospholipid receptor and present the lipid-bound structure of the LIMP-2 luminal domain dimer and discuss its lipid traf...

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Autores principales:	Karen S. Conrad, Ting-Wen Cheng, Daniel Ysselstein, Saskia Heybrock, Lise R. Hoth, Boris A. Chrunyk, Christopher W. am Ende, Dimitri Krainc, Michael Schwake, Paul Saftig, Shenping Liu, Xiayang Qiu, Michael D. Ehlers
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2017
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/89053b7dbfca4e9d97832de177661289
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spelling	oai:doaj.org-article:89053b7dbfca4e9d97832de1776612892021-12-02T14:41:20ZLysosomal integral membrane protein-2 as a phospholipid receptor revealed by biophysical and cellular studies10.1038/s41467-017-02044-82041-1723https://doaj.org/article/89053b7dbfca4e9d97832de1776612892017-12-01T00:00:00Zhttps://doi.org/10.1038/s41467-017-02044-8https://doaj.org/toc/2041-1723Lysosomal integral membrane protein-2 (LIMP-2) is a glucocerebrosidase receptor, which is linked to kidney failure and other diseases. Here the authors show that LIMP-2 is also a phospholipid receptor and present the lipid-bound structure of the LIMP-2 luminal domain dimer and discuss its lipid trafficking mechanism.Karen S. ConradTing-Wen ChengDaniel YsselsteinSaskia HeybrockLise R. HothBoris A. ChrunykChristopher W. am EndeDimitri KraincMichael SchwakePaul SaftigShenping LiuXiayang QiuMichael D. EhlersNature PortfolioarticleScienceQENNature Communications, Vol 8, Iss 1, Pp 1-13 (2017)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Karen S. Conrad Ting-Wen Cheng Daniel Ysselstein Saskia Heybrock Lise R. Hoth Boris A. Chrunyk Christopher W. am Ende Dimitri Krainc Michael Schwake Paul Saftig Shenping Liu Xiayang Qiu Michael D. Ehlers Lysosomal integral membrane protein-2 as a phospholipid receptor revealed by biophysical and cellular studies
description	Lysosomal integral membrane protein-2 (LIMP-2) is a glucocerebrosidase receptor, which is linked to kidney failure and other diseases. Here the authors show that LIMP-2 is also a phospholipid receptor and present the lipid-bound structure of the LIMP-2 luminal domain dimer and discuss its lipid trafficking mechanism.
format	article
author	Karen S. Conrad Ting-Wen Cheng Daniel Ysselstein Saskia Heybrock Lise R. Hoth Boris A. Chrunyk Christopher W. am Ende Dimitri Krainc Michael Schwake Paul Saftig Shenping Liu Xiayang Qiu Michael D. Ehlers
author_facet	Karen S. Conrad Ting-Wen Cheng Daniel Ysselstein Saskia Heybrock Lise R. Hoth Boris A. Chrunyk Christopher W. am Ende Dimitri Krainc Michael Schwake Paul Saftig Shenping Liu Xiayang Qiu Michael D. Ehlers
author_sort	Karen S. Conrad
title	Lysosomal integral membrane protein-2 as a phospholipid receptor revealed by biophysical and cellular studies
title_short	Lysosomal integral membrane protein-2 as a phospholipid receptor revealed by biophysical and cellular studies
title_full	Lysosomal integral membrane protein-2 as a phospholipid receptor revealed by biophysical and cellular studies
title_fullStr	Lysosomal integral membrane protein-2 as a phospholipid receptor revealed by biophysical and cellular studies
title_full_unstemmed	Lysosomal integral membrane protein-2 as a phospholipid receptor revealed by biophysical and cellular studies
title_sort	lysosomal integral membrane protein-2 as a phospholipid receptor revealed by biophysical and cellular studies
publisher	Nature Portfolio
publishDate	2017
url	https://doaj.org/article/89053b7dbfca4e9d97832de177661289
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Lysosomal integral membrane protein-2 as a phospholipid receptor revealed by biophysical and cellular studies

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