Ecological Effect of Arginine on Oral Microbiota

Abstract Dental caries is closely associated with the microbial dybiosis between acidogenic/aciduric pathogens and alkali-generating commensal bacteria colonized in the oral cavity. Our recent studies have shown that arginine may represent a promising anti-caries agent by modulating microbial compos...

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Autores principales:	Xin Zheng, Jinzhi He, Lin Wang, Shuangshuang Zhou, Xian Peng, Shi Huang, Liwei Zheng, Lei Cheng, Yuqing Hao, Jiyao Li, Jian Xu, Xin Xu, Xuedong Zhou
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2017
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/8905cd22e4a94a0f945fab5bbb425bf1
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spelling	oai:doaj.org-article:8905cd22e4a94a0f945fab5bbb425bf12021-12-02T11:52:38ZEcological Effect of Arginine on Oral Microbiota10.1038/s41598-017-07042-w2045-2322https://doaj.org/article/8905cd22e4a94a0f945fab5bbb425bf12017-08-01T00:00:00Zhttps://doi.org/10.1038/s41598-017-07042-whttps://doaj.org/toc/2045-2322Abstract Dental caries is closely associated with the microbial dybiosis between acidogenic/aciduric pathogens and alkali-generating commensal bacteria colonized in the oral cavity. Our recent studies have shown that arginine may represent a promising anti-caries agent by modulating microbial composition in an in vitro consortium. However, the effect of arginine on the oral microbiota has yet to be comprehensively delineated in either clinical cohort or in vitro biofilm models that better represent the microbial diversity of oral cavity. Here, by employing a clinical cohort and a saliva-derived biofilm model, we demonstrated that arginine treatment could favorably modulate the oral microbiota of caries-active individuals. Specifically, treatment with arginine-containing dentifrice normalized the oral microbiota of caries-active individuals similar to that of caries-free controls in terms of microbial structure, abundance of typical species, enzymatic activities of glycolysis and alkali-generation related enzymes and their corresponding transcripts. Moreover, we found that combinatory use of arginine with fluoride could better enrich alkali-generating Streptococcus sanguinis and suppress acidogenic/aciduric Streptococcus mutans, and thus significantly retard the demineralizing capability of saliva-derived oral biofilm. Hence, we propose that fluoride and arginine have a potential synergistic effect in maintaining an eco-friendly oral microbial equilibrium in favor of better caries management.Xin ZhengJinzhi HeLin WangShuangshuang ZhouXian PengShi HuangLiwei ZhengLei ChengYuqing HaoJiyao LiJian XuXin XuXuedong ZhouNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 7, Iss 1, Pp 1-10 (2017)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Xin Zheng Jinzhi He Lin Wang Shuangshuang Zhou Xian Peng Shi Huang Liwei Zheng Lei Cheng Yuqing Hao Jiyao Li Jian Xu Xin Xu Xuedong Zhou Ecological Effect of Arginine on Oral Microbiota
description	Abstract Dental caries is closely associated with the microbial dybiosis between acidogenic/aciduric pathogens and alkali-generating commensal bacteria colonized in the oral cavity. Our recent studies have shown that arginine may represent a promising anti-caries agent by modulating microbial composition in an in vitro consortium. However, the effect of arginine on the oral microbiota has yet to be comprehensively delineated in either clinical cohort or in vitro biofilm models that better represent the microbial diversity of oral cavity. Here, by employing a clinical cohort and a saliva-derived biofilm model, we demonstrated that arginine treatment could favorably modulate the oral microbiota of caries-active individuals. Specifically, treatment with arginine-containing dentifrice normalized the oral microbiota of caries-active individuals similar to that of caries-free controls in terms of microbial structure, abundance of typical species, enzymatic activities of glycolysis and alkali-generation related enzymes and their corresponding transcripts. Moreover, we found that combinatory use of arginine with fluoride could better enrich alkali-generating Streptococcus sanguinis and suppress acidogenic/aciduric Streptococcus mutans, and thus significantly retard the demineralizing capability of saliva-derived oral biofilm. Hence, we propose that fluoride and arginine have a potential synergistic effect in maintaining an eco-friendly oral microbial equilibrium in favor of better caries management.
format	article
author	Xin Zheng Jinzhi He Lin Wang Shuangshuang Zhou Xian Peng Shi Huang Liwei Zheng Lei Cheng Yuqing Hao Jiyao Li Jian Xu Xin Xu Xuedong Zhou
author_facet	Xin Zheng Jinzhi He Lin Wang Shuangshuang Zhou Xian Peng Shi Huang Liwei Zheng Lei Cheng Yuqing Hao Jiyao Li Jian Xu Xin Xu Xuedong Zhou
author_sort	Xin Zheng
title	Ecological Effect of Arginine on Oral Microbiota
title_short	Ecological Effect of Arginine on Oral Microbiota
title_full	Ecological Effect of Arginine on Oral Microbiota
title_fullStr	Ecological Effect of Arginine on Oral Microbiota
title_full_unstemmed	Ecological Effect of Arginine on Oral Microbiota
title_sort	ecological effect of arginine on oral microbiota
publisher	Nature Portfolio
publishDate	2017
url	https://doaj.org/article/8905cd22e4a94a0f945fab5bbb425bf1
work_keys_str_mv	AT xinzheng ecologicaleffectofarginineonoralmicrobiota AT jinzhihe ecologicaleffectofarginineonoralmicrobiota AT linwang ecologicaleffectofarginineonoralmicrobiota AT shuangshuangzhou ecologicaleffectofarginineonoralmicrobiota AT xianpeng ecologicaleffectofarginineonoralmicrobiota AT shihuang ecologicaleffectofarginineonoralmicrobiota AT liweizheng ecologicaleffectofarginineonoralmicrobiota AT leicheng ecologicaleffectofarginineonoralmicrobiota AT yuqinghao ecologicaleffectofarginineonoralmicrobiota AT jiyaoli ecologicaleffectofarginineonoralmicrobiota AT jianxu ecologicaleffectofarginineonoralmicrobiota AT xinxu ecologicaleffectofarginineonoralmicrobiota AT xuedongzhou ecologicaleffectofarginineonoralmicrobiota
_version_	1718394994849480704

Ecological Effect of Arginine on Oral Microbiota

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