Clinical characteristics of family-clustered onset of coronavirus disease 2019 in Jilin Province, China

Eight members of a big family with laboratory-confirmed COVID-19 pneumonia were admitted to First Hospital of Jilin University, Changchun, China, from 28 January to 5 February 2020. The clinical records, laboratory results, and chest computed tomography (CT) scans were retrospectively reviewed. Thro...

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Autores principales:	Na Du, Yanfang Jiang, Qing Zhang, Lihe Che, Xiaohua Li, Lixin Lou, Wanguo Bao, Shucheng Hua
Formato:	article
Lenguaje:	EN
Publicado:	Taylor & Francis Group 2020
Materias:	covid-19 family-cluster ct images Infectious and parasitic diseases RC109-216
Acceso en línea:	https://doaj.org/article/8906773a4e3e484cadd3894001ffa673
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spelling	oai:doaj.org-article:8906773a4e3e484cadd3894001ffa6732021-11-17T14:21:59ZClinical characteristics of family-clustered onset of coronavirus disease 2019 in Jilin Province, China2150-55942150-560810.1080/21505594.2020.1816075https://doaj.org/article/8906773a4e3e484cadd3894001ffa6732020-12-01T00:00:00Zhttp://dx.doi.org/10.1080/21505594.2020.1816075https://doaj.org/toc/2150-5594https://doaj.org/toc/2150-5608Eight members of a big family with laboratory-confirmed COVID-19 pneumonia were admitted to First Hospital of Jilin University, Changchun, China, from 28 January to 5 February 2020. The clinical records, laboratory results, and chest computed tomography (CT) scans were retrospectively reviewed. Throat swab samples were positive for severe acute respiratory syndrome coronavirus 2, confirmed by the Center for Disease Control and Prevention of Changchun. All eight patients had fever of different degrees; and 6, 3, and 2 had cough; diarrhea; and sore throat. With disease progression, the percentage of lymphocytes in older patients increased, CT images worsened, and the ratio of lymphocytes increased when images revealed inflammation absorption. Although the CT images showed ground-glass opacities in the youngest patient, his lymphocyte count did not decrease with mild clinical symptoms, and the images showed that inflammation was quickly absorbed. Only the oldest patient developed critical illness. The C reaction protein (CRP) levels of Patient 5 increased significantly, and the rate of decline was the slowest, while his condition was the most severe. The clinical manifestations of COVID-19 in this family cluster varied with contact, age, and underlying disease. Lymphocyte count and quality of chest CT images appeared inversely associated with disease severity. CRP changes may be an indicator of disease severity and prognosis.Na DuYanfang JiangQing ZhangLihe CheXiaohua LiLixin LouWanguo BaoShucheng HuaTaylor & Francis Grouparticlecovid-19family-clusterct imagesInfectious and parasitic diseasesRC109-216ENVirulence, Vol 11, Iss 1, Pp 1240-1249 (2020)
institution	DOAJ
collection	DOAJ
language	EN
topic	covid-19 family-cluster ct images Infectious and parasitic diseases RC109-216
spellingShingle	covid-19 family-cluster ct images Infectious and parasitic diseases RC109-216 Na Du Yanfang Jiang Qing Zhang Lihe Che Xiaohua Li Lixin Lou Wanguo Bao Shucheng Hua Clinical characteristics of family-clustered onset of coronavirus disease 2019 in Jilin Province, China
description	Eight members of a big family with laboratory-confirmed COVID-19 pneumonia were admitted to First Hospital of Jilin University, Changchun, China, from 28 January to 5 February 2020. The clinical records, laboratory results, and chest computed tomography (CT) scans were retrospectively reviewed. Throat swab samples were positive for severe acute respiratory syndrome coronavirus 2, confirmed by the Center for Disease Control and Prevention of Changchun. All eight patients had fever of different degrees; and 6, 3, and 2 had cough; diarrhea; and sore throat. With disease progression, the percentage of lymphocytes in older patients increased, CT images worsened, and the ratio of lymphocytes increased when images revealed inflammation absorption. Although the CT images showed ground-glass opacities in the youngest patient, his lymphocyte count did not decrease with mild clinical symptoms, and the images showed that inflammation was quickly absorbed. Only the oldest patient developed critical illness. The C reaction protein (CRP) levels of Patient 5 increased significantly, and the rate of decline was the slowest, while his condition was the most severe. The clinical manifestations of COVID-19 in this family cluster varied with contact, age, and underlying disease. Lymphocyte count and quality of chest CT images appeared inversely associated with disease severity. CRP changes may be an indicator of disease severity and prognosis.
format	article
author	Na Du Yanfang Jiang Qing Zhang Lihe Che Xiaohua Li Lixin Lou Wanguo Bao Shucheng Hua
author_facet	Na Du Yanfang Jiang Qing Zhang Lihe Che Xiaohua Li Lixin Lou Wanguo Bao Shucheng Hua
author_sort	Na Du
title	Clinical characteristics of family-clustered onset of coronavirus disease 2019 in Jilin Province, China
title_short	Clinical characteristics of family-clustered onset of coronavirus disease 2019 in Jilin Province, China
title_full	Clinical characteristics of family-clustered onset of coronavirus disease 2019 in Jilin Province, China
title_fullStr	Clinical characteristics of family-clustered onset of coronavirus disease 2019 in Jilin Province, China
title_full_unstemmed	Clinical characteristics of family-clustered onset of coronavirus disease 2019 in Jilin Province, China
title_sort	clinical characteristics of family-clustered onset of coronavirus disease 2019 in jilin province, china
publisher	Taylor & Francis Group
publishDate	2020
url	https://doaj.org/article/8906773a4e3e484cadd3894001ffa673
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Clinical characteristics of family-clustered onset of coronavirus disease 2019 in Jilin Province, China

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