PEPD is a pivotal regulator of p53 tumor suppressor

p53 is a pivotal tumour suppressor that is activated by various cellular stress inducers. Here, the authors show that peptidase D (PEPD) promotes the growth of cancer cells by suppressing p53 and that the complex PEPD-p53 is critical for robust p53 activation in response to stress signals.

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Autores principales:	Lu Yang, Yun Li, Arup Bhattacharya, Yuesheng Zhang
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2017
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/8906903619f242569689966908f927ec
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id	oai:doaj.org-article:8906903619f242569689966908f927ec
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spelling	oai:doaj.org-article:8906903619f242569689966908f927ec2021-12-02T15:38:59ZPEPD is a pivotal regulator of p53 tumor suppressor10.1038/s41467-017-02097-92041-1723https://doaj.org/article/8906903619f242569689966908f927ec2017-12-01T00:00:00Zhttps://doi.org/10.1038/s41467-017-02097-9https://doaj.org/toc/2041-1723p53 is a pivotal tumour suppressor that is activated by various cellular stress inducers. Here, the authors show that peptidase D (PEPD) promotes the growth of cancer cells by suppressing p53 and that the complex PEPD-p53 is critical for robust p53 activation in response to stress signals.Lu YangYun LiArup BhattacharyaYuesheng ZhangNature PortfolioarticleScienceQENNature Communications, Vol 8, Iss 1, Pp 1-15 (2017)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Lu Yang Yun Li Arup Bhattacharya Yuesheng Zhang PEPD is a pivotal regulator of p53 tumor suppressor
description	p53 is a pivotal tumour suppressor that is activated by various cellular stress inducers. Here, the authors show that peptidase D (PEPD) promotes the growth of cancer cells by suppressing p53 and that the complex PEPD-p53 is critical for robust p53 activation in response to stress signals.
format	article
author	Lu Yang Yun Li Arup Bhattacharya Yuesheng Zhang
author_facet	Lu Yang Yun Li Arup Bhattacharya Yuesheng Zhang
author_sort	Lu Yang
title	PEPD is a pivotal regulator of p53 tumor suppressor
title_short	PEPD is a pivotal regulator of p53 tumor suppressor
title_full	PEPD is a pivotal regulator of p53 tumor suppressor
title_fullStr	PEPD is a pivotal regulator of p53 tumor suppressor
title_full_unstemmed	PEPD is a pivotal regulator of p53 tumor suppressor
title_sort	pepd is a pivotal regulator of p53 tumor suppressor
publisher	Nature Portfolio
publishDate	2017
url	https://doaj.org/article/8906903619f242569689966908f927ec
work_keys_str_mv	AT luyang pepdisapivotalregulatorofp53tumorsuppressor AT yunli pepdisapivotalregulatorofp53tumorsuppressor AT arupbhattacharya pepdisapivotalregulatorofp53tumorsuppressor AT yueshengzhang pepdisapivotalregulatorofp53tumorsuppressor
_version_	1718386000370073600

PEPD is a pivotal regulator of p53 tumor suppressor

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