Multiple signaling kinases target Mrc1 to prevent genomic instability triggered by transcription-replication conflicts

During S phase of the cell cycle, transcription and replication need to be coordinated in order to avoid conflicts leading to potential genomic instability. Here, the authors find that Mrc1 integrates signals from different kinases to regulate replication during unscheduled transcription events.

Guardado en:

Detalles Bibliográficos
Autores principales:	Alba Duch, Berta Canal, Sonia I. Barroso, María García-Rubio, Gerhard Seisenbacher, Andrés Aguilera, Eulàlia de Nadal, Francesc Posas
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2018
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/890cd55d01074eb4acae28ff6220fd5b
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

id	oai:doaj.org-article:890cd55d01074eb4acae28ff6220fd5b
record_format	dspace
spelling	oai:doaj.org-article:890cd55d01074eb4acae28ff6220fd5b2021-12-02T15:34:36ZMultiple signaling kinases target Mrc1 to prevent genomic instability triggered by transcription-replication conflicts10.1038/s41467-017-02756-x2041-1723https://doaj.org/article/890cd55d01074eb4acae28ff6220fd5b2018-01-01T00:00:00Zhttps://doi.org/10.1038/s41467-017-02756-xhttps://doaj.org/toc/2041-1723During S phase of the cell cycle, transcription and replication need to be coordinated in order to avoid conflicts leading to potential genomic instability. Here, the authors find that Mrc1 integrates signals from different kinases to regulate replication during unscheduled transcription events.Alba DuchBerta CanalSonia I. BarrosoMaría García-RubioGerhard SeisenbacherAndrés AguileraEulàlia de NadalFrancesc PosasNature PortfolioarticleScienceQENNature Communications, Vol 9, Iss 1, Pp 1-14 (2018)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Alba Duch Berta Canal Sonia I. Barroso María García-Rubio Gerhard Seisenbacher Andrés Aguilera Eulàlia de Nadal Francesc Posas Multiple signaling kinases target Mrc1 to prevent genomic instability triggered by transcription-replication conflicts
description	During S phase of the cell cycle, transcription and replication need to be coordinated in order to avoid conflicts leading to potential genomic instability. Here, the authors find that Mrc1 integrates signals from different kinases to regulate replication during unscheduled transcription events.
format	article
author	Alba Duch Berta Canal Sonia I. Barroso María García-Rubio Gerhard Seisenbacher Andrés Aguilera Eulàlia de Nadal Francesc Posas
author_facet	Alba Duch Berta Canal Sonia I. Barroso María García-Rubio Gerhard Seisenbacher Andrés Aguilera Eulàlia de Nadal Francesc Posas
author_sort	Alba Duch
title	Multiple signaling kinases target Mrc1 to prevent genomic instability triggered by transcription-replication conflicts
title_short	Multiple signaling kinases target Mrc1 to prevent genomic instability triggered by transcription-replication conflicts
title_full	Multiple signaling kinases target Mrc1 to prevent genomic instability triggered by transcription-replication conflicts
title_fullStr	Multiple signaling kinases target Mrc1 to prevent genomic instability triggered by transcription-replication conflicts
title_full_unstemmed	Multiple signaling kinases target Mrc1 to prevent genomic instability triggered by transcription-replication conflicts
title_sort	multiple signaling kinases target mrc1 to prevent genomic instability triggered by transcription-replication conflicts
publisher	Nature Portfolio
publishDate	2018
url	https://doaj.org/article/890cd55d01074eb4acae28ff6220fd5b
work_keys_str_mv	AT albaduch multiplesignalingkinasestargetmrc1topreventgenomicinstabilitytriggeredbytranscriptionreplicationconflicts AT bertacanal multiplesignalingkinasestargetmrc1topreventgenomicinstabilitytriggeredbytranscriptionreplicationconflicts AT soniaibarroso multiplesignalingkinasestargetmrc1topreventgenomicinstabilitytriggeredbytranscriptionreplicationconflicts AT mariagarciarubio multiplesignalingkinasestargetmrc1topreventgenomicinstabilitytriggeredbytranscriptionreplicationconflicts AT gerhardseisenbacher multiplesignalingkinasestargetmrc1topreventgenomicinstabilitytriggeredbytranscriptionreplicationconflicts AT andresaguilera multiplesignalingkinasestargetmrc1topreventgenomicinstabilitytriggeredbytranscriptionreplicationconflicts AT eulaliadenadal multiplesignalingkinasestargetmrc1topreventgenomicinstabilitytriggeredbytranscriptionreplicationconflicts AT francescposas multiplesignalingkinasestargetmrc1topreventgenomicinstabilitytriggeredbytranscriptionreplicationconflicts
_version_	1718386791045660672

Multiple signaling kinases target Mrc1 to prevent genomic instability triggered by transcription-replication conflicts

Ejemplares similares