Evaluating Incidence, Location, and Predictors of Positive Surgical Margin Among Chinese Men Undergoing Robot-Assisted Radical Prostatectomy

Purpose To evaluate the incidence and locations of positive surgical margin (PSM) among Chinese men undergoing RARP and identify the preoperative predictors for PSM. Methods We retrospectively identified 393 patients who underwent RARP according to inclusion criteria by single surgeon in our hospita...

Descripción completa

Guardado en:

Detalles Bibliográficos
Autores principales:	Wugong Qu MSc, Shuanbao Yu MD, Jin Tao MSc, Biao Dong MD, Yafeng Fan MSc, Haopeng Du MSc, Haotian Deng MSc, Junxiao Liu MSc, Xuepei Zhang MD
Formato:	article
Lenguaje:	EN
Publicado:	SAGE Publishing 2021
Materias:	Neoplasms. Tumors. Oncology. Including cancer and carcinogens RC254-282
Acceso en línea:	https://doaj.org/article/890f3af329b546168e6dc25193f4caf1
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

id	oai:doaj.org-article:890f3af329b546168e6dc25193f4caf1
record_format	dspace
spelling	oai:doaj.org-article:890f3af329b546168e6dc25193f4caf12021-11-19T23:04:38ZEvaluating Incidence, Location, and Predictors of Positive Surgical Margin Among Chinese Men Undergoing Robot-Assisted Radical Prostatectomy1073-274810.1177/10732748211055265https://doaj.org/article/890f3af329b546168e6dc25193f4caf12021-10-01T00:00:00Zhttps://doi.org/10.1177/10732748211055265https://doaj.org/toc/1073-2748Purpose To evaluate the incidence and locations of positive surgical margin (PSM) among Chinese men undergoing RARP and identify the preoperative predictors for PSM. Methods We retrospectively identified 393 patients who underwent RARP according to inclusion criteria by single surgeon in our hospital. PSM was defined as the presence of cancer adjacent to inked surface of the specimen and categorized into four groups based on locations: apex, posterolateral, base, and multifocal. Logistic regression analysis was performed to identify the predictors of overall and location-specific PSM. Results The overall PSM rate was 133/393 (34%). The PSM rates for pT2, pT3, and pT4 stage were 63/278 (23%), 50/89 (56%), and 20/26 (77%), respectively. The estimated rates for apical, posterolateral, basal, and multifocal PSM were 8%, 4%, 7%, and 14%, respectively. In univariate analysis, overall PSM related to tPSA, f/tPSA, percentage of positive needles, and Gleason score. Multifocal PSM correlated with smoking history, drinking history, tPSA, f/tPSA, percentage of positive needles, and Gleason score. In multivariate analysis, percentage of positive needles reminded the only independent predictor for overall (OR = 10.5, 95% CI: 2.58–44.4) and basal PSM (OR = 24.0, 95% CI: 3.22–179.4). The f/tPSA (OR = 2.59, 95% CI: 2.18–5.71) and percentage of positive needles (OR = 31.0, 95% CI: 3.17–303) were independent risk factors for multifocal PSM. Conclusion The multifocal sites were the most common location of positive surgical margin, followed by apical and basal sites among Chinese patients undergoing RARP. The percentage of positive needles was an independent predictor for overall, basal, and multifocal PSM.Wugong Qu MScShuanbao Yu MDJin Tao MScBiao Dong MDYafeng Fan MScHaopeng Du MScHaotian Deng MScJunxiao Liu MScXuepei Zhang MDSAGE PublishingarticleNeoplasms. Tumors. Oncology. Including cancer and carcinogensRC254-282ENCancer Control, Vol 28 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Neoplasms. Tumors. Oncology. Including cancer and carcinogens RC254-282
spellingShingle	Neoplasms. Tumors. Oncology. Including cancer and carcinogens RC254-282 Wugong Qu MSc Shuanbao Yu MD Jin Tao MSc Biao Dong MD Yafeng Fan MSc Haopeng Du MSc Haotian Deng MSc Junxiao Liu MSc Xuepei Zhang MD Evaluating Incidence, Location, and Predictors of Positive Surgical Margin Among Chinese Men Undergoing Robot-Assisted Radical Prostatectomy
description	Purpose To evaluate the incidence and locations of positive surgical margin (PSM) among Chinese men undergoing RARP and identify the preoperative predictors for PSM. Methods We retrospectively identified 393 patients who underwent RARP according to inclusion criteria by single surgeon in our hospital. PSM was defined as the presence of cancer adjacent to inked surface of the specimen and categorized into four groups based on locations: apex, posterolateral, base, and multifocal. Logistic regression analysis was performed to identify the predictors of overall and location-specific PSM. Results The overall PSM rate was 133/393 (34%). The PSM rates for pT2, pT3, and pT4 stage were 63/278 (23%), 50/89 (56%), and 20/26 (77%), respectively. The estimated rates for apical, posterolateral, basal, and multifocal PSM were 8%, 4%, 7%, and 14%, respectively. In univariate analysis, overall PSM related to tPSA, f/tPSA, percentage of positive needles, and Gleason score. Multifocal PSM correlated with smoking history, drinking history, tPSA, f/tPSA, percentage of positive needles, and Gleason score. In multivariate analysis, percentage of positive needles reminded the only independent predictor for overall (OR = 10.5, 95% CI: 2.58–44.4) and basal PSM (OR = 24.0, 95% CI: 3.22–179.4). The f/tPSA (OR = 2.59, 95% CI: 2.18–5.71) and percentage of positive needles (OR = 31.0, 95% CI: 3.17–303) were independent risk factors for multifocal PSM. Conclusion The multifocal sites were the most common location of positive surgical margin, followed by apical and basal sites among Chinese patients undergoing RARP. The percentage of positive needles was an independent predictor for overall, basal, and multifocal PSM.
format	article
author	Wugong Qu MSc Shuanbao Yu MD Jin Tao MSc Biao Dong MD Yafeng Fan MSc Haopeng Du MSc Haotian Deng MSc Junxiao Liu MSc Xuepei Zhang MD
author_facet	Wugong Qu MSc Shuanbao Yu MD Jin Tao MSc Biao Dong MD Yafeng Fan MSc Haopeng Du MSc Haotian Deng MSc Junxiao Liu MSc Xuepei Zhang MD
author_sort	Wugong Qu MSc
title	Evaluating Incidence, Location, and Predictors of Positive Surgical Margin Among Chinese Men Undergoing Robot-Assisted Radical Prostatectomy
title_short	Evaluating Incidence, Location, and Predictors of Positive Surgical Margin Among Chinese Men Undergoing Robot-Assisted Radical Prostatectomy
title_full	Evaluating Incidence, Location, and Predictors of Positive Surgical Margin Among Chinese Men Undergoing Robot-Assisted Radical Prostatectomy
title_fullStr	Evaluating Incidence, Location, and Predictors of Positive Surgical Margin Among Chinese Men Undergoing Robot-Assisted Radical Prostatectomy
title_full_unstemmed	Evaluating Incidence, Location, and Predictors of Positive Surgical Margin Among Chinese Men Undergoing Robot-Assisted Radical Prostatectomy
title_sort	evaluating incidence, location, and predictors of positive surgical margin among chinese men undergoing robot-assisted radical prostatectomy
publisher	SAGE Publishing
publishDate	2021
url	https://doaj.org/article/890f3af329b546168e6dc25193f4caf1
work_keys_str_mv	AT wugongqumsc evaluatingincidencelocationandpredictorsofpositivesurgicalmarginamongchinesemenundergoingrobotassistedradicalprostatectomy AT shuanbaoyumd evaluatingincidencelocationandpredictorsofpositivesurgicalmarginamongchinesemenundergoingrobotassistedradicalprostatectomy AT jintaomsc evaluatingincidencelocationandpredictorsofpositivesurgicalmarginamongchinesemenundergoingrobotassistedradicalprostatectomy AT biaodongmd evaluatingincidencelocationandpredictorsofpositivesurgicalmarginamongchinesemenundergoingrobotassistedradicalprostatectomy AT yafengfanmsc evaluatingincidencelocationandpredictorsofpositivesurgicalmarginamongchinesemenundergoingrobotassistedradicalprostatectomy AT haopengdumsc evaluatingincidencelocationandpredictorsofpositivesurgicalmarginamongchinesemenundergoingrobotassistedradicalprostatectomy AT haotiandengmsc evaluatingincidencelocationandpredictorsofpositivesurgicalmarginamongchinesemenundergoingrobotassistedradicalprostatectomy AT junxiaoliumsc evaluatingincidencelocationandpredictorsofpositivesurgicalmarginamongchinesemenundergoingrobotassistedradicalprostatectomy AT xuepeizhangmd evaluatingincidencelocationandpredictorsofpositivesurgicalmarginamongchinesemenundergoingrobotassistedradicalprostatectomy
_version_	1718419846267404288

Evaluating Incidence, Location, and Predictors of Positive Surgical Margin Among Chinese Men Undergoing Robot-Assisted Radical Prostatectomy

Ejemplares similares