Higher fetal insulin resistance in Chinese pregnant women with gestational diabetes mellitus and correlation with maternal insulin resistance.

<h4>Objective</h4>The aim of this study was to determine the effect of gestational diabetes mellitus (GDM) on fetal insulin resistance or β-cell function in Chinese pregnant women with GDM.<h4>Measurements</h4>Maternal fasting blood and venous cord blood samples (reflecting f...

Descripción completa

Guardado en:

Detalles Bibliográficos
Autores principales:	Qiuwei Wang, Ruiping Huang, Bin Yu, Fang Cao, Huiyan Wang, Ming Zhang, Xinhong Wang, Bin Zhang, Hong Zhou, Ziqiang Zhu
Formato:	article
Lenguaje:	EN
Publicado:	Public Library of Science (PLoS) 2013
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/8915fa6124874ebf9cab8af184cea61a
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

id	oai:doaj.org-article:8915fa6124874ebf9cab8af184cea61a
record_format	dspace
spelling	oai:doaj.org-article:8915fa6124874ebf9cab8af184cea61a2021-11-18T07:51:14ZHigher fetal insulin resistance in Chinese pregnant women with gestational diabetes mellitus and correlation with maternal insulin resistance.1932-620310.1371/journal.pone.0059845https://doaj.org/article/8915fa6124874ebf9cab8af184cea61a2013-01-01T00:00:00Zhttps://www.ncbi.nlm.nih.gov/pmc/articles/pmid/23560057/?tool=EBIhttps://doaj.org/toc/1932-6203<h4>Objective</h4>The aim of this study was to determine the effect of gestational diabetes mellitus (GDM) on fetal insulin resistance or β-cell function in Chinese pregnant women with GDM.<h4>Measurements</h4>Maternal fasting blood and venous cord blood samples (reflecting fetal condition) were collected in 65 well-controlled Chinese GDM mothers (only given dietary intervention) and 83 control subjects. The insulin, glucose and proinsulin concentrations of both maternal and cord blood samples were measured, and the homeostasis model assessment of insulin resistance (HOMA-IR) and the proinsulin-to-insulin ratios (an indicator of fetal β-cell function) were calculated in maternal and cord blood respectively.<h4>Results</h4>Both maternal and fetal levels of insulin, proinsulin and HOMA-IR but not proinsulin-to-insulin ratios were significantly higher in the GDM group than in the control group (maternal insulin, 24.8 vs. 15.4 µU/mL, P = 0.004, proinsulin, 23.3 vs. 16.2 pmol/L, P = 0.005, and HOMA-IR, 5.5 vs. 3.5, P = 0.041, respectively; fetal: insulin, 15.1 vs. 7.9 µU/mL, P<0.001, proinsulin, 25.8 vs. 15.1 pmol/L, P = 0.015, and HOMA-IR, 2.8 vs. 1.4, P = 0.017, respectively). Fetal HOMA-IR but not proinsulin-to-insulin ratios was significantly correlated to maternal HOMA-IR (r = 0.307, P = 0.019), in the pregnant women with GDM.<h4>Conclusions</h4>Fetal insulin resistance was higher in Chinese pregnant women with GDM than control subjects, and correlated with maternal insulin resistance.Qiuwei WangRuiping HuangBin YuFang CaoHuiyan WangMing ZhangXinhong WangBin ZhangHong ZhouZiqiang ZhuPublic Library of Science (PLoS)articleMedicineRScienceQENPLoS ONE, Vol 8, Iss 4, p e59845 (2013)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Qiuwei Wang Ruiping Huang Bin Yu Fang Cao Huiyan Wang Ming Zhang Xinhong Wang Bin Zhang Hong Zhou Ziqiang Zhu Higher fetal insulin resistance in Chinese pregnant women with gestational diabetes mellitus and correlation with maternal insulin resistance.
description	<h4>Objective</h4>The aim of this study was to determine the effect of gestational diabetes mellitus (GDM) on fetal insulin resistance or β-cell function in Chinese pregnant women with GDM.<h4>Measurements</h4>Maternal fasting blood and venous cord blood samples (reflecting fetal condition) were collected in 65 well-controlled Chinese GDM mothers (only given dietary intervention) and 83 control subjects. The insulin, glucose and proinsulin concentrations of both maternal and cord blood samples were measured, and the homeostasis model assessment of insulin resistance (HOMA-IR) and the proinsulin-to-insulin ratios (an indicator of fetal β-cell function) were calculated in maternal and cord blood respectively.<h4>Results</h4>Both maternal and fetal levels of insulin, proinsulin and HOMA-IR but not proinsulin-to-insulin ratios were significantly higher in the GDM group than in the control group (maternal insulin, 24.8 vs. 15.4 µU/mL, P = 0.004, proinsulin, 23.3 vs. 16.2 pmol/L, P = 0.005, and HOMA-IR, 5.5 vs. 3.5, P = 0.041, respectively; fetal: insulin, 15.1 vs. 7.9 µU/mL, P<0.001, proinsulin, 25.8 vs. 15.1 pmol/L, P = 0.015, and HOMA-IR, 2.8 vs. 1.4, P = 0.017, respectively). Fetal HOMA-IR but not proinsulin-to-insulin ratios was significantly correlated to maternal HOMA-IR (r = 0.307, P = 0.019), in the pregnant women with GDM.<h4>Conclusions</h4>Fetal insulin resistance was higher in Chinese pregnant women with GDM than control subjects, and correlated with maternal insulin resistance.
format	article
author	Qiuwei Wang Ruiping Huang Bin Yu Fang Cao Huiyan Wang Ming Zhang Xinhong Wang Bin Zhang Hong Zhou Ziqiang Zhu
author_facet	Qiuwei Wang Ruiping Huang Bin Yu Fang Cao Huiyan Wang Ming Zhang Xinhong Wang Bin Zhang Hong Zhou Ziqiang Zhu
author_sort	Qiuwei Wang
title	Higher fetal insulin resistance in Chinese pregnant women with gestational diabetes mellitus and correlation with maternal insulin resistance.
title_short	Higher fetal insulin resistance in Chinese pregnant women with gestational diabetes mellitus and correlation with maternal insulin resistance.
title_full	Higher fetal insulin resistance in Chinese pregnant women with gestational diabetes mellitus and correlation with maternal insulin resistance.
title_fullStr	Higher fetal insulin resistance in Chinese pregnant women with gestational diabetes mellitus and correlation with maternal insulin resistance.
title_full_unstemmed	Higher fetal insulin resistance in Chinese pregnant women with gestational diabetes mellitus and correlation with maternal insulin resistance.
title_sort	higher fetal insulin resistance in chinese pregnant women with gestational diabetes mellitus and correlation with maternal insulin resistance.
publisher	Public Library of Science (PLoS)
publishDate	2013
url	https://doaj.org/article/8915fa6124874ebf9cab8af184cea61a
work_keys_str_mv	AT qiuweiwang higherfetalinsulinresistanceinchinesepregnantwomenwithgestationaldiabetesmellitusandcorrelationwithmaternalinsulinresistance AT ruipinghuang higherfetalinsulinresistanceinchinesepregnantwomenwithgestationaldiabetesmellitusandcorrelationwithmaternalinsulinresistance AT binyu higherfetalinsulinresistanceinchinesepregnantwomenwithgestationaldiabetesmellitusandcorrelationwithmaternalinsulinresistance AT fangcao higherfetalinsulinresistanceinchinesepregnantwomenwithgestationaldiabetesmellitusandcorrelationwithmaternalinsulinresistance AT huiyanwang higherfetalinsulinresistanceinchinesepregnantwomenwithgestationaldiabetesmellitusandcorrelationwithmaternalinsulinresistance AT mingzhang higherfetalinsulinresistanceinchinesepregnantwomenwithgestationaldiabetesmellitusandcorrelationwithmaternalinsulinresistance AT xinhongwang higherfetalinsulinresistanceinchinesepregnantwomenwithgestationaldiabetesmellitusandcorrelationwithmaternalinsulinresistance AT binzhang higherfetalinsulinresistanceinchinesepregnantwomenwithgestationaldiabetesmellitusandcorrelationwithmaternalinsulinresistance AT hongzhou higherfetalinsulinresistanceinchinesepregnantwomenwithgestationaldiabetesmellitusandcorrelationwithmaternalinsulinresistance AT ziqiangzhu higherfetalinsulinresistanceinchinesepregnantwomenwithgestationaldiabetesmellitusandcorrelationwithmaternalinsulinresistance
_version_	1718422866414796800

Higher fetal insulin resistance in Chinese pregnant women with gestational diabetes mellitus and correlation with maternal insulin resistance.

Ejemplares similares