Antibody-drug conjugates with dual payloads for combating breast tumor heterogeneity and drug resistance

Intratumor heterogeneity in breast cancer can limit the clinical success of antibody-drug conjugates (ADCs). In this study, the authors develop dual payload Her2-ADCs that show potent anti-tumor activity against heterogeneous breast tumors in vivo.

Guardado en:

Detalles Bibliográficos
Autores principales:	Chisato M. Yamazaki, Aiko Yamaguchi, Yasuaki Anami, Wei Xiong, Yoshihiro Otani, Jangsoon Lee, Naoto T. Ueno, Ningyan Zhang, Zhiqiang An, Kyoji Tsuchikama
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/89230ea929c14625992165bf821e7857
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

id	oai:doaj.org-article:89230ea929c14625992165bf821e7857
record_format	dspace
spelling	oai:doaj.org-article:89230ea929c14625992165bf821e78572021-12-02T14:58:18ZAntibody-drug conjugates with dual payloads for combating breast tumor heterogeneity and drug resistance10.1038/s41467-021-23793-72041-1723https://doaj.org/article/89230ea929c14625992165bf821e78572021-06-01T00:00:00Zhttps://doi.org/10.1038/s41467-021-23793-7https://doaj.org/toc/2041-1723Intratumor heterogeneity in breast cancer can limit the clinical success of antibody-drug conjugates (ADCs). In this study, the authors develop dual payload Her2-ADCs that show potent anti-tumor activity against heterogeneous breast tumors in vivo.Chisato M. YamazakiAiko YamaguchiYasuaki AnamiWei XiongYoshihiro OtaniJangsoon LeeNaoto T. UenoNingyan ZhangZhiqiang AnKyoji TsuchikamaNature PortfolioarticleScienceQENNature Communications, Vol 12, Iss 1, Pp 1-13 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Chisato M. Yamazaki Aiko Yamaguchi Yasuaki Anami Wei Xiong Yoshihiro Otani Jangsoon Lee Naoto T. Ueno Ningyan Zhang Zhiqiang An Kyoji Tsuchikama Antibody-drug conjugates with dual payloads for combating breast tumor heterogeneity and drug resistance
description	Intratumor heterogeneity in breast cancer can limit the clinical success of antibody-drug conjugates (ADCs). In this study, the authors develop dual payload Her2-ADCs that show potent anti-tumor activity against heterogeneous breast tumors in vivo.
format	article
author	Chisato M. Yamazaki Aiko Yamaguchi Yasuaki Anami Wei Xiong Yoshihiro Otani Jangsoon Lee Naoto T. Ueno Ningyan Zhang Zhiqiang An Kyoji Tsuchikama
author_facet	Chisato M. Yamazaki Aiko Yamaguchi Yasuaki Anami Wei Xiong Yoshihiro Otani Jangsoon Lee Naoto T. Ueno Ningyan Zhang Zhiqiang An Kyoji Tsuchikama
author_sort	Chisato M. Yamazaki
title	Antibody-drug conjugates with dual payloads for combating breast tumor heterogeneity and drug resistance
title_short	Antibody-drug conjugates with dual payloads for combating breast tumor heterogeneity and drug resistance
title_full	Antibody-drug conjugates with dual payloads for combating breast tumor heterogeneity and drug resistance
title_fullStr	Antibody-drug conjugates with dual payloads for combating breast tumor heterogeneity and drug resistance
title_full_unstemmed	Antibody-drug conjugates with dual payloads for combating breast tumor heterogeneity and drug resistance
title_sort	antibody-drug conjugates with dual payloads for combating breast tumor heterogeneity and drug resistance
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/89230ea929c14625992165bf821e7857
work_keys_str_mv	AT chisatomyamazaki antibodydrugconjugateswithdualpayloadsforcombatingbreasttumorheterogeneityanddrugresistance AT aikoyamaguchi antibodydrugconjugateswithdualpayloadsforcombatingbreasttumorheterogeneityanddrugresistance AT yasuakianami antibodydrugconjugateswithdualpayloadsforcombatingbreasttumorheterogeneityanddrugresistance AT weixiong antibodydrugconjugateswithdualpayloadsforcombatingbreasttumorheterogeneityanddrugresistance AT yoshihirootani antibodydrugconjugateswithdualpayloadsforcombatingbreasttumorheterogeneityanddrugresistance AT jangsoonlee antibodydrugconjugateswithdualpayloadsforcombatingbreasttumorheterogeneityanddrugresistance AT naototueno antibodydrugconjugateswithdualpayloadsforcombatingbreasttumorheterogeneityanddrugresistance AT ningyanzhang antibodydrugconjugateswithdualpayloadsforcombatingbreasttumorheterogeneityanddrugresistance AT zhiqiangan antibodydrugconjugateswithdualpayloadsforcombatingbreasttumorheterogeneityanddrugresistance AT kyojitsuchikama antibodydrugconjugateswithdualpayloadsforcombatingbreasttumorheterogeneityanddrugresistance
_version_	1718389334718021632

Antibody-drug conjugates with dual payloads for combating breast tumor heterogeneity and drug resistance

Ejemplares similares