Associations of BRAP polymorphisms with the risk of alcohol dependence and scores on the Alcohol Use Disorders Identification Test

Jee Wook Kim,1,2 Young Min Choe,1,2 Joong-Gon Shin,3 Byung Lae Park,4 Hyung-Doo Shin,3,4 Ihn-Geun Choi,2,5 Boung Chul Lee2,6 1Department of Neuropsychiatry, Hallym University Dongtan Sacred Heart Hospital, Hwaseong, Gyeonggi Province, Republic of Korea; 2Department of Psychiatry, Hallym University...

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Autores principales:	Kim JW, Choe YM, Shin JG, Park BL, Shin HD, Choi IG, Lee BC
Formato:	article
Lenguaje:	EN
Publicado:	Dove Medical Press 2018
Materias:	Alcohol dependence AUDIT genome-wide association study single nucleotide polymorphism BRAP Neurosciences. Biological psychiatry. Neuropsychiatry RC321-571 Neurology. Diseases of the nervous system RC346-429
Acceso en línea:	https://doaj.org/article/89248c8b9ea6483b9b74ff81d8fb1f0a
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spelling	oai:doaj.org-article:89248c8b9ea6483b9b74ff81d8fb1f0a2021-12-02T02:29:39ZAssociations of BRAP polymorphisms with the risk of alcohol dependence and scores on the Alcohol Use Disorders Identification Test1178-2021https://doaj.org/article/89248c8b9ea6483b9b74ff81d8fb1f0a2018-12-01T00:00:00Zhttps://www.dovepress.com/associations-of-brap-polymorphisms-with-the-risk-of-alcohol-dependence-peer-reviewed-article-NDThttps://doaj.org/toc/1178-2021Jee Wook Kim,1,2 Young Min Choe,1,2 Joong-Gon Shin,3 Byung Lae Park,4 Hyung-Doo Shin,3,4 Ihn-Geun Choi,2,5 Boung Chul Lee2,6 1Department of Neuropsychiatry, Hallym University Dongtan Sacred Heart Hospital, Hwaseong, Gyeonggi Province, Republic of Korea; 2Department of Psychiatry, Hallym University College of Medicine, Chuncheon, Republic of Korea; 3Department of Life Science, Sogang University, Seoul, Republic of Korea; 4Department of Genetic Epidemiology, SNP Genetics, Inc., Seoul, Republic of Korea; 5Department of Neuropsychiatry, Hallym University Kangnam Sacred Heart Hospital, Seoul, Republic of Korea; 6Department of Neuropsychiatry, Hallym University Hangang Sacred Heart Hospital, Seoul, Republic of Korea Background: Alcohol dependence (AD) is a common disorder that is influenced by genetic as well as environmental factors. A previous genome-wide association study (GWAS) of the Korean population performed by our research group identified a number of genes, including BRCA1-associated protein (BRAP) and protein arginine methyltransferase 8 (PRMT8), as novel genetic markers of AD. Methods: The present investigation was a fine-mapping follow-up study of 459 AD and 455 non-AD subjects of Korean descent to determine the associations between BRAP and PRMT8 polymorphisms and AD. The Alcohol Use Disorders Identification Test (AUDIT) was administered to screen for the degree of AD risk in the subjects and 58 genetic variants, 5 for BRAP and 53 for PRMT8, were genotyped for subsequent association analyses. Results: In the present case–control analysis, BRAP rs3782886 showed the most significant association signal with a risk of AD (P=1.29×10-16, Pcorr =7.74×10-16, OR =0.19). There were also significant differences in the overall and subcategory scores for the BRAP genetic variants, including rs3782886 (P=9.94×10-31, Pcorr =5.96×10-30 at rs3782886 for the overall AUDIT score). However, the genetic effects of PRMT8 polymorphisms observed in our previous GWAS were not replicated in the present study (minimum P=0.0005, Pcorr >0.05, OR =0.30 at rs4766139 in the recessive model). Furthermore, the single-nucleotide polymorphisms of PRMT8 were not associated with the overall and subcategory AUDIT scores. Conclusion: The present findings suggest that the genetic variants of BRAP may contribute to a predisposition for an alcohol use disorder. Keywords: alcohol dependence, AUDIT, genome-wide association study, single-nucleotide polymorphism, BRAPKim JWChoe YMShin JGPark BLShin HDChoi IGLee BCDove Medical PressarticleAlcohol dependenceAUDITgenome-wide association studysingle nucleotide polymorphismBRAPNeurosciences. Biological psychiatry. NeuropsychiatryRC321-571Neurology. Diseases of the nervous systemRC346-429ENNeuropsychiatric Disease and Treatment, Vol Volume 15, Pp 83-94 (2018)
institution	DOAJ
collection	DOAJ
language	EN
topic	Alcohol dependence AUDIT genome-wide association study single nucleotide polymorphism BRAP Neurosciences. Biological psychiatry. Neuropsychiatry RC321-571 Neurology. Diseases of the nervous system RC346-429
spellingShingle	Alcohol dependence AUDIT genome-wide association study single nucleotide polymorphism BRAP Neurosciences. Biological psychiatry. Neuropsychiatry RC321-571 Neurology. Diseases of the nervous system RC346-429 Kim JW Choe YM Shin JG Park BL Shin HD Choi IG Lee BC Associations of BRAP polymorphisms with the risk of alcohol dependence and scores on the Alcohol Use Disorders Identification Test
description	Jee Wook Kim,1,2 Young Min Choe,1,2 Joong-Gon Shin,3 Byung Lae Park,4 Hyung-Doo Shin,3,4 Ihn-Geun Choi,2,5 Boung Chul Lee2,6 1Department of Neuropsychiatry, Hallym University Dongtan Sacred Heart Hospital, Hwaseong, Gyeonggi Province, Republic of Korea; 2Department of Psychiatry, Hallym University College of Medicine, Chuncheon, Republic of Korea; 3Department of Life Science, Sogang University, Seoul, Republic of Korea; 4Department of Genetic Epidemiology, SNP Genetics, Inc., Seoul, Republic of Korea; 5Department of Neuropsychiatry, Hallym University Kangnam Sacred Heart Hospital, Seoul, Republic of Korea; 6Department of Neuropsychiatry, Hallym University Hangang Sacred Heart Hospital, Seoul, Republic of Korea Background: Alcohol dependence (AD) is a common disorder that is influenced by genetic as well as environmental factors. A previous genome-wide association study (GWAS) of the Korean population performed by our research group identified a number of genes, including BRCA1-associated protein (BRAP) and protein arginine methyltransferase 8 (PRMT8), as novel genetic markers of AD. Methods: The present investigation was a fine-mapping follow-up study of 459 AD and 455 non-AD subjects of Korean descent to determine the associations between BRAP and PRMT8 polymorphisms and AD. The Alcohol Use Disorders Identification Test (AUDIT) was administered to screen for the degree of AD risk in the subjects and 58 genetic variants, 5 for BRAP and 53 for PRMT8, were genotyped for subsequent association analyses. Results: In the present case–control analysis, BRAP rs3782886 showed the most significant association signal with a risk of AD (P=1.29×10-16, Pcorr =7.74×10-16, OR =0.19). There were also significant differences in the overall and subcategory scores for the BRAP genetic variants, including rs3782886 (P=9.94×10-31, Pcorr =5.96×10-30 at rs3782886 for the overall AUDIT score). However, the genetic effects of PRMT8 polymorphisms observed in our previous GWAS were not replicated in the present study (minimum P=0.0005, Pcorr >0.05, OR =0.30 at rs4766139 in the recessive model). Furthermore, the single-nucleotide polymorphisms of PRMT8 were not associated with the overall and subcategory AUDIT scores. Conclusion: The present findings suggest that the genetic variants of BRAP may contribute to a predisposition for an alcohol use disorder. Keywords: alcohol dependence, AUDIT, genome-wide association study, single-nucleotide polymorphism, BRAP
format	article
author	Kim JW Choe YM Shin JG Park BL Shin HD Choi IG Lee BC
author_facet	Kim JW Choe YM Shin JG Park BL Shin HD Choi IG Lee BC
author_sort	Kim JW
title	Associations of BRAP polymorphisms with the risk of alcohol dependence and scores on the Alcohol Use Disorders Identification Test
title_short	Associations of BRAP polymorphisms with the risk of alcohol dependence and scores on the Alcohol Use Disorders Identification Test
title_full	Associations of BRAP polymorphisms with the risk of alcohol dependence and scores on the Alcohol Use Disorders Identification Test
title_fullStr	Associations of BRAP polymorphisms with the risk of alcohol dependence and scores on the Alcohol Use Disorders Identification Test
title_full_unstemmed	Associations of BRAP polymorphisms with the risk of alcohol dependence and scores on the Alcohol Use Disorders Identification Test
title_sort	associations of brap polymorphisms with the risk of alcohol dependence and scores on the alcohol use disorders identification test
publisher	Dove Medical Press
publishDate	2018
url	https://doaj.org/article/89248c8b9ea6483b9b74ff81d8fb1f0a
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Associations of BRAP polymorphisms with the risk of alcohol dependence and scores on the Alcohol Use Disorders Identification Test

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