Predictive values of early head computed tomography for survival outcome after cardiac arrest in childhood: a pilot study

Abstract Predicting outcomes of children after cardiac arrest (CA) remains challenging. To identify useful prognostic markers for pediatric CA, we retrospectively analyzed the early findings of head computed tomography (CT) of patients. Subjects were non-traumatic, out-of-hospital CA patients < 1...

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Autores principales:	Kenichi Tetsuhara, Noriyuki Kaku, Yuka Watanabe, Masaya Kumamoto, Yuko Ichimiya, Soichi Mizuguchi, Kanako Higashi, Wakato Matsuoka, Yoshitomo Motomura, Masafumi Sanefuji, Akio Hiwatashi, Yasunari Sakai, Shouichi Ohga
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/892574f5ebdc41bc983ed52a95db03fc
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spelling	oai:doaj.org-article:892574f5ebdc41bc983ed52a95db03fc2021-12-02T17:52:32ZPredictive values of early head computed tomography for survival outcome after cardiac arrest in childhood: a pilot study10.1038/s41598-021-91628-y2045-2322https://doaj.org/article/892574f5ebdc41bc983ed52a95db03fc2021-06-01T00:00:00Zhttps://doi.org/10.1038/s41598-021-91628-yhttps://doaj.org/toc/2045-2322Abstract Predicting outcomes of children after cardiac arrest (CA) remains challenging. To identify useful prognostic markers for pediatric CA, we retrospectively analyzed the early findings of head computed tomography (CT) of patients. Subjects were non-traumatic, out-of-hospital CA patients < 16 years of age who underwent the first head CT within 24 h in our institute from 2006 to 2018 (n = 70, median age: 4 months, range 0–163). Of the 24 patients with return of spontaneous circulation, 14 survived up to 30 days after CA. The degree of brain damage was quantitatively measured with modified methods of the Alberta Stroke Program Early CT Score (mASPECTS) and simplified gray-matter-attenuation-to-white-matter-attenuation ratio (sGWR). The 14 survivors showed higher mASPECTS values than the 56 non-survivors (p = 0.035). All 3 patients with mASPECTS scores ≥ 20 survived, while an sGWR ≥ 1.14 indicated a higher chance of survival than an sGWR < 1.14 (54.5% vs. 13.6%). Follow-up magnetic resonance imaging for survivors validated the correlation of the mASPECTS < 15 with severe brain damage. Thus, low mASPECTS scores were associated with unfavorable neurological outcomes on the Pediatric Cerebral Performance Category scale. A quantitative analysis of early head CT findings might provide clues for predicting survival of pediatric CA.Kenichi TetsuharaNoriyuki KakuYuka WatanabeMasaya KumamotoYuko IchimiyaSoichi MizuguchiKanako HigashiWakato MatsuokaYoshitomo MotomuraMasafumi SanefujiAkio HiwatashiYasunari SakaiShouichi OhgaNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 11, Iss 1, Pp 1-11 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Kenichi Tetsuhara Noriyuki Kaku Yuka Watanabe Masaya Kumamoto Yuko Ichimiya Soichi Mizuguchi Kanako Higashi Wakato Matsuoka Yoshitomo Motomura Masafumi Sanefuji Akio Hiwatashi Yasunari Sakai Shouichi Ohga Predictive values of early head computed tomography for survival outcome after cardiac arrest in childhood: a pilot study
description	Abstract Predicting outcomes of children after cardiac arrest (CA) remains challenging. To identify useful prognostic markers for pediatric CA, we retrospectively analyzed the early findings of head computed tomography (CT) of patients. Subjects were non-traumatic, out-of-hospital CA patients < 16 years of age who underwent the first head CT within 24 h in our institute from 2006 to 2018 (n = 70, median age: 4 months, range 0–163). Of the 24 patients with return of spontaneous circulation, 14 survived up to 30 days after CA. The degree of brain damage was quantitatively measured with modified methods of the Alberta Stroke Program Early CT Score (mASPECTS) and simplified gray-matter-attenuation-to-white-matter-attenuation ratio (sGWR). The 14 survivors showed higher mASPECTS values than the 56 non-survivors (p = 0.035). All 3 patients with mASPECTS scores ≥ 20 survived, while an sGWR ≥ 1.14 indicated a higher chance of survival than an sGWR < 1.14 (54.5% vs. 13.6%). Follow-up magnetic resonance imaging for survivors validated the correlation of the mASPECTS < 15 with severe brain damage. Thus, low mASPECTS scores were associated with unfavorable neurological outcomes on the Pediatric Cerebral Performance Category scale. A quantitative analysis of early head CT findings might provide clues for predicting survival of pediatric CA.
format	article
author	Kenichi Tetsuhara Noriyuki Kaku Yuka Watanabe Masaya Kumamoto Yuko Ichimiya Soichi Mizuguchi Kanako Higashi Wakato Matsuoka Yoshitomo Motomura Masafumi Sanefuji Akio Hiwatashi Yasunari Sakai Shouichi Ohga
author_facet	Kenichi Tetsuhara Noriyuki Kaku Yuka Watanabe Masaya Kumamoto Yuko Ichimiya Soichi Mizuguchi Kanako Higashi Wakato Matsuoka Yoshitomo Motomura Masafumi Sanefuji Akio Hiwatashi Yasunari Sakai Shouichi Ohga
author_sort	Kenichi Tetsuhara
title	Predictive values of early head computed tomography for survival outcome after cardiac arrest in childhood: a pilot study
title_short	Predictive values of early head computed tomography for survival outcome after cardiac arrest in childhood: a pilot study
title_full	Predictive values of early head computed tomography for survival outcome after cardiac arrest in childhood: a pilot study
title_fullStr	Predictive values of early head computed tomography for survival outcome after cardiac arrest in childhood: a pilot study
title_full_unstemmed	Predictive values of early head computed tomography for survival outcome after cardiac arrest in childhood: a pilot study
title_sort	predictive values of early head computed tomography for survival outcome after cardiac arrest in childhood: a pilot study
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/892574f5ebdc41bc983ed52a95db03fc
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Predictive values of early head computed tomography for survival outcome after cardiac arrest in childhood: a pilot study

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