Validity of the common cold questionnaire (CCQ) in asthma exacerbations.

<h4>Background</h4>The common cold questionnaire (CCQ) is used to discriminate those with and without a viral infection. Its usefulness in people with acute asthma is unknown. Our aim was to assess the ability of the CCQ to detect viral infection and to monitor recovery during a viral in...

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Autores principales:	Heather Powell, Joanne Smart, Lisa G Wood, Terry Grissell, Darren R Shafren, Michael J Hensley, Peter G Gibson
Formato:	article
Lenguaje:	EN
Publicado:	Public Library of Science (PLoS) 2008
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/8927b832b0b940cabc3cebb7e769e648
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spelling	oai:doaj.org-article:8927b832b0b940cabc3cebb7e769e6482021-11-25T06:13:04ZValidity of the common cold questionnaire (CCQ) in asthma exacerbations.1932-620310.1371/journal.pone.0001802https://doaj.org/article/8927b832b0b940cabc3cebb7e769e6482008-03-01T00:00:00Zhttps://www.ncbi.nlm.nih.gov/pmc/articles/pmid/18350141/pdf/?tool=EBIhttps://doaj.org/toc/1932-6203<h4>Background</h4>The common cold questionnaire (CCQ) is used to discriminate those with and without a viral infection. Its usefulness in people with acute asthma is unknown. Our aim was to assess the ability of the CCQ to detect viral infection and to monitor recovery during a viral induced asthma exacerbation and confirmed by virological testing.<h4>Methodology/principal findings</h4>We studied subjects (> or =7 yrs) admitted to hospital with acute asthma and diagnosed as positive (n = 63), or negative to viral infection (n = 27) according to molecular and virological testing from respiratory samples. CCQ, asthma history and asthma control questionnaires were completed and repeated 4-6 weeks later. Sensitivity, specificity, and response to change of the CCQ were assessed by receiver operator curve (ROC) analysis and effect size calculation respectively. The CCQ did not discriminate between viral and non-viral infection for subjects with asthma (sensitivity = 76.2%; specificity = 29.6%). ROC analysis could not differentiate between positive or negative virus in subjects with asthma. The CCQ had a large response to change following recovery (effect size = 1.01). 39% of subjects recovering from viral exacerbation remained positive to virological testing at follow-up despite improvement in clinical symptoms. The CCQ reflected clinical improvement in these subjects, thus providing additional information to complement virological testing.<h4>Conclusions/significance</h4>The CCQ is a useful instrument for monitoring response to viral infection in people with asthma. Reliable differentiation between viral and non-viral asthma exacerbations was not achieved with the CCQ and requires specific virological testing. When combined with virological testing, the CCQ should be a useful outcome measure for evaluating therapies in viral-induced asthma.Heather PowellJoanne SmartLisa G WoodTerry GrissellDarren R ShafrenMichael J HensleyPeter G GibsonPublic Library of Science (PLoS)articleMedicineRScienceQENPLoS ONE, Vol 3, Iss 3, p e1802 (2008)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Heather Powell Joanne Smart Lisa G Wood Terry Grissell Darren R Shafren Michael J Hensley Peter G Gibson Validity of the common cold questionnaire (CCQ) in asthma exacerbations.
description	<h4>Background</h4>The common cold questionnaire (CCQ) is used to discriminate those with and without a viral infection. Its usefulness in people with acute asthma is unknown. Our aim was to assess the ability of the CCQ to detect viral infection and to monitor recovery during a viral induced asthma exacerbation and confirmed by virological testing.<h4>Methodology/principal findings</h4>We studied subjects (> or =7 yrs) admitted to hospital with acute asthma and diagnosed as positive (n = 63), or negative to viral infection (n = 27) according to molecular and virological testing from respiratory samples. CCQ, asthma history and asthma control questionnaires were completed and repeated 4-6 weeks later. Sensitivity, specificity, and response to change of the CCQ were assessed by receiver operator curve (ROC) analysis and effect size calculation respectively. The CCQ did not discriminate between viral and non-viral infection for subjects with asthma (sensitivity = 76.2%; specificity = 29.6%). ROC analysis could not differentiate between positive or negative virus in subjects with asthma. The CCQ had a large response to change following recovery (effect size = 1.01). 39% of subjects recovering from viral exacerbation remained positive to virological testing at follow-up despite improvement in clinical symptoms. The CCQ reflected clinical improvement in these subjects, thus providing additional information to complement virological testing.<h4>Conclusions/significance</h4>The CCQ is a useful instrument for monitoring response to viral infection in people with asthma. Reliable differentiation between viral and non-viral asthma exacerbations was not achieved with the CCQ and requires specific virological testing. When combined with virological testing, the CCQ should be a useful outcome measure for evaluating therapies in viral-induced asthma.
format	article
author	Heather Powell Joanne Smart Lisa G Wood Terry Grissell Darren R Shafren Michael J Hensley Peter G Gibson
author_facet	Heather Powell Joanne Smart Lisa G Wood Terry Grissell Darren R Shafren Michael J Hensley Peter G Gibson
author_sort	Heather Powell
title	Validity of the common cold questionnaire (CCQ) in asthma exacerbations.
title_short	Validity of the common cold questionnaire (CCQ) in asthma exacerbations.
title_full	Validity of the common cold questionnaire (CCQ) in asthma exacerbations.
title_fullStr	Validity of the common cold questionnaire (CCQ) in asthma exacerbations.
title_full_unstemmed	Validity of the common cold questionnaire (CCQ) in asthma exacerbations.
title_sort	validity of the common cold questionnaire (ccq) in asthma exacerbations.
publisher	Public Library of Science (PLoS)
publishDate	2008
url	https://doaj.org/article/8927b832b0b940cabc3cebb7e769e648
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Validity of the common cold questionnaire (CCQ) in asthma exacerbations.

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