Combined low level light therapy and intense pulsed light therapy for the treatment of meibomian gland dysfunction

Karl Stonecipher,1 Thomas G Abell,2 Bennett Chotiner,3 Erik Chotiner,3 Rick Potvin41Physicians Protocol, Greensboro, NC, USA; 2Abell Eyes, Lexington, KY, USA; 3Memorial Eye Institute, Harrisburg, PA, USA; 4Science in Vision, Akron, NY, USAPurpose: To evaluate the effects of combined intense pulsed l...

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Autores principales:	Stonecipher K, Abell TG, Chotiner B, Chotiner E, Potvin R
Formato:	article
Lenguaje:	EN
Publicado:	Dove Medical Press 2019
Materias:	LLLT low level light therapy IPL intense pulsed light meibomian gland dysfunction ocular surface disease index OSDI dry eye disease Ophthalmology RE1-994
Acceso en línea:	https://doaj.org/article/89296105b1954e93ad433ab11fe7d6eb
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spelling	oai:doaj.org-article:89296105b1954e93ad433ab11fe7d6eb2021-12-02T03:07:19ZCombined low level light therapy and intense pulsed light therapy for the treatment of meibomian gland dysfunction1177-5483https://doaj.org/article/89296105b1954e93ad433ab11fe7d6eb2019-06-01T00:00:00Zhttps://www.dovepress.com/combined-low-level-light-therapy-and-intense-pulsed-light-therapy-for--peer-reviewed-article-OPTHhttps://doaj.org/toc/1177-5483Karl Stonecipher,1 Thomas G Abell,2 Bennett Chotiner,3 Erik Chotiner,3 Rick Potvin41Physicians Protocol, Greensboro, NC, USA; 2Abell Eyes, Lexington, KY, USA; 3Memorial Eye Institute, Harrisburg, PA, USA; 4Science in Vision, Akron, NY, USAPurpose: To evaluate the effects of combined intense pulsed light therapy (IPL) and low-level light therapy (LLLT) on clinical measures of dry eye related to severe meibomian gland disease (MGD) in subjects unresponsive to previous medical management.Patients and Methods: This was a retrospective chart review of patients treated by 4 physicians at 3 centers. All patients were documented treatment failures with traditional pharmaceutical therapy. They all had their MGD evaluated before treatment using a grading scale (0–4), tear breakup time in seconds and the Ocular Surface Disease Index (OSDI) questionnaire. To be included, all patients had to have had a short course of adjunct pharmaceutical or device-related therapy, along with a combined IPL/LLLT treatment. As well, a second MGD evaluation with the same three measures had to have been conducted 1–3 months post treatment.Results: A total of 460 eyes of 230 patients were identified for inclusion in the data set. Mean OSDI scores were significantly lower after treatment; 70.4% of patients had pretreatment OSDI scores indicative of dry eye; this dropped to 29.1% of patients after treatment. A 1-step or greater reduction in MGD grading was observed in 70% of eyes, with 28% of eyes having a 2-step or greater reduction. Tear breakup time was ≤6 seconds in 86.7% of eyes pretreatment, dropping to 33.9% of eyes after treatment. There were no ocular or facial adverse events or side effects related to the combined light treatment.Conclusion: The use of combined IPL/LLLT for the treatment of severe MGD appears to be beneficial in patients who have failed topical and/or systemic therapy.Keywords: LLLT, low level light therapy, IPL, intense pulsed light, meibomian gland dysfunction, ocular surface disease index Stonecipher KAbell TGChotiner BChotiner EPotvin RDove Medical PressarticleLLLTlow level light therapyIPLintense pulsed lightmeibomian gland dysfunctionocular surface disease indexOSDIdry eye diseaseOphthalmologyRE1-994ENClinical Ophthalmology, Vol Volume 13, Pp 993-999 (2019)
institution	DOAJ
collection	DOAJ
language	EN
topic	LLLT low level light therapy IPL intense pulsed light meibomian gland dysfunction ocular surface disease index OSDI dry eye disease Ophthalmology RE1-994
spellingShingle	LLLT low level light therapy IPL intense pulsed light meibomian gland dysfunction ocular surface disease index OSDI dry eye disease Ophthalmology RE1-994 Stonecipher K Abell TG Chotiner B Chotiner E Potvin R Combined low level light therapy and intense pulsed light therapy for the treatment of meibomian gland dysfunction
description	Karl Stonecipher,1 Thomas G Abell,2 Bennett Chotiner,3 Erik Chotiner,3 Rick Potvin41Physicians Protocol, Greensboro, NC, USA; 2Abell Eyes, Lexington, KY, USA; 3Memorial Eye Institute, Harrisburg, PA, USA; 4Science in Vision, Akron, NY, USAPurpose: To evaluate the effects of combined intense pulsed light therapy (IPL) and low-level light therapy (LLLT) on clinical measures of dry eye related to severe meibomian gland disease (MGD) in subjects unresponsive to previous medical management.Patients and Methods: This was a retrospective chart review of patients treated by 4 physicians at 3 centers. All patients were documented treatment failures with traditional pharmaceutical therapy. They all had their MGD evaluated before treatment using a grading scale (0–4), tear breakup time in seconds and the Ocular Surface Disease Index (OSDI) questionnaire. To be included, all patients had to have had a short course of adjunct pharmaceutical or device-related therapy, along with a combined IPL/LLLT treatment. As well, a second MGD evaluation with the same three measures had to have been conducted 1–3 months post treatment.Results: A total of 460 eyes of 230 patients were identified for inclusion in the data set. Mean OSDI scores were significantly lower after treatment; 70.4% of patients had pretreatment OSDI scores indicative of dry eye; this dropped to 29.1% of patients after treatment. A 1-step or greater reduction in MGD grading was observed in 70% of eyes, with 28% of eyes having a 2-step or greater reduction. Tear breakup time was ≤6 seconds in 86.7% of eyes pretreatment, dropping to 33.9% of eyes after treatment. There were no ocular or facial adverse events or side effects related to the combined light treatment.Conclusion: The use of combined IPL/LLLT for the treatment of severe MGD appears to be beneficial in patients who have failed topical and/or systemic therapy.Keywords: LLLT, low level light therapy, IPL, intense pulsed light, meibomian gland dysfunction, ocular surface disease index
format	article
author	Stonecipher K Abell TG Chotiner B Chotiner E Potvin R
author_facet	Stonecipher K Abell TG Chotiner B Chotiner E Potvin R
author_sort	Stonecipher K
title	Combined low level light therapy and intense pulsed light therapy for the treatment of meibomian gland dysfunction
title_short	Combined low level light therapy and intense pulsed light therapy for the treatment of meibomian gland dysfunction
title_full	Combined low level light therapy and intense pulsed light therapy for the treatment of meibomian gland dysfunction
title_fullStr	Combined low level light therapy and intense pulsed light therapy for the treatment of meibomian gland dysfunction
title_full_unstemmed	Combined low level light therapy and intense pulsed light therapy for the treatment of meibomian gland dysfunction
title_sort	combined low level light therapy and intense pulsed light therapy for the treatment of meibomian gland dysfunction
publisher	Dove Medical Press
publishDate	2019
url	https://doaj.org/article/89296105b1954e93ad433ab11fe7d6eb
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Combined low level light therapy and intense pulsed light therapy for the treatment of meibomian gland dysfunction

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