Improvement of physico-chemical properties of dextran-chitosan composite scaffolds by addition of nano-hydroxyapatite

Abstract Nano-hydroxyapatite was incorporated into polymer matrix of Dextran/Chitosan to achieve a novel composite scaffold by freeze drying technique. The synthesized composite scaffolds were recognized by different performances such as: X-ray diffraction (XRD), Fourier transform infrared spectrosc...

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Autores principales:	Emad El-Meliegy, N. I. Abu-Elsaad, Abeer M. El-Kady, Manar A. Ibrahim
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2018
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/892b1dc6d5c34df8884276ee7838e472
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spelling	oai:doaj.org-article:892b1dc6d5c34df8884276ee7838e4722021-12-02T11:41:02ZImprovement of physico-chemical properties of dextran-chitosan composite scaffolds by addition of nano-hydroxyapatite10.1038/s41598-018-30720-22045-2322https://doaj.org/article/892b1dc6d5c34df8884276ee7838e4722018-08-01T00:00:00Zhttps://doi.org/10.1038/s41598-018-30720-2https://doaj.org/toc/2045-2322Abstract Nano-hydroxyapatite was incorporated into polymer matrix of Dextran/Chitosan to achieve a novel composite scaffold by freeze drying technique. The synthesized composite scaffolds were recognized by different performances such as: X-ray diffraction (XRD), Fourier transform infrared spectroscopy (FT-IR) and Scanning electron microscope (SEM). The results revealed the complex formation between dextran and chitosan with an excellent dispersion of nHA inside the polymer matrix. The SEM images showed the presence of interconnected pore structure inside the scaffolds. The porosity of the composites was found to decrease from 82% to 67% by adding nanohydroxyapatite to the polymer matrix of Dextran/Chitosan. The mechanical properties of the scaffolds were measured by compression test. The obtained results verified that the presence of nHA can noticeably enhance young’s modulus and compressive strength of the composite scaffolds. All the obtained results essentially recommend that these composites can be a good candidate for bone tissue engineering applications.Emad El-MeliegyN. I. Abu-ElsaadAbeer M. El-KadyManar A. IbrahimNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 8, Iss 1, Pp 1-10 (2018)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Emad El-Meliegy N. I. Abu-Elsaad Abeer M. El-Kady Manar A. Ibrahim Improvement of physico-chemical properties of dextran-chitosan composite scaffolds by addition of nano-hydroxyapatite
description	Abstract Nano-hydroxyapatite was incorporated into polymer matrix of Dextran/Chitosan to achieve a novel composite scaffold by freeze drying technique. The synthesized composite scaffolds were recognized by different performances such as: X-ray diffraction (XRD), Fourier transform infrared spectroscopy (FT-IR) and Scanning electron microscope (SEM). The results revealed the complex formation between dextran and chitosan with an excellent dispersion of nHA inside the polymer matrix. The SEM images showed the presence of interconnected pore structure inside the scaffolds. The porosity of the composites was found to decrease from 82% to 67% by adding nanohydroxyapatite to the polymer matrix of Dextran/Chitosan. The mechanical properties of the scaffolds were measured by compression test. The obtained results verified that the presence of nHA can noticeably enhance young’s modulus and compressive strength of the composite scaffolds. All the obtained results essentially recommend that these composites can be a good candidate for bone tissue engineering applications.
format	article
author	Emad El-Meliegy N. I. Abu-Elsaad Abeer M. El-Kady Manar A. Ibrahim
author_facet	Emad El-Meliegy N. I. Abu-Elsaad Abeer M. El-Kady Manar A. Ibrahim
author_sort	Emad El-Meliegy
title	Improvement of physico-chemical properties of dextran-chitosan composite scaffolds by addition of nano-hydroxyapatite
title_short	Improvement of physico-chemical properties of dextran-chitosan composite scaffolds by addition of nano-hydroxyapatite
title_full	Improvement of physico-chemical properties of dextran-chitosan composite scaffolds by addition of nano-hydroxyapatite
title_fullStr	Improvement of physico-chemical properties of dextran-chitosan composite scaffolds by addition of nano-hydroxyapatite
title_full_unstemmed	Improvement of physico-chemical properties of dextran-chitosan composite scaffolds by addition of nano-hydroxyapatite
title_sort	improvement of physico-chemical properties of dextran-chitosan composite scaffolds by addition of nano-hydroxyapatite
publisher	Nature Portfolio
publishDate	2018
url	https://doaj.org/article/892b1dc6d5c34df8884276ee7838e472
work_keys_str_mv	AT emadelmeliegy improvementofphysicochemicalpropertiesofdextranchitosancompositescaffoldsbyadditionofnanohydroxyapatite AT niabuelsaad improvementofphysicochemicalpropertiesofdextranchitosancompositescaffoldsbyadditionofnanohydroxyapatite AT abeermelkady improvementofphysicochemicalpropertiesofdextranchitosancompositescaffoldsbyadditionofnanohydroxyapatite AT manaraibrahim improvementofphysicochemicalpropertiesofdextranchitosancompositescaffoldsbyadditionofnanohydroxyapatite
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Improvement of physico-chemical properties of dextran-chitosan composite scaffolds by addition of nano-hydroxyapatite

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