Role of Rab GTPases in Hepatocellular Carcinoma

Chun-Cheng Yang,1,&ast; Guang-Xiao Meng,1,&ast; Zhao-Ru Dong,1,&ast; Tao Li1,2 1Department of General Surgery, Qilu Hospital, Shandong University, Jinan, People’s Republic of China; 2Department of Hepatobiliary Surgery, The Second Hospital of Shandong University, Jinan, People’s Republic...

Descripción completa

Guardado en:

Detalles Bibliográficos
Autores principales:	Yang CC, Meng GX, Dong ZR, Li T
Formato:	article
Lenguaje:	EN
Publicado:	Dove Medical Press 2021
Materias:	rab gtpase membrane trafficking hepatocellular carcinoma therapeutic target Neoplasms. Tumors. Oncology. Including cancer and carcinogens RC254-282
Acceso en línea:	https://doaj.org/article/8934e8c52eb3484a95d672ce9a3b388b
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

id	oai:doaj.org-article:8934e8c52eb3484a95d672ce9a3b388b
record_format	dspace
spelling	oai:doaj.org-article:8934e8c52eb3484a95d672ce9a3b388b2021-11-21T19:08:51ZRole of Rab GTPases in Hepatocellular Carcinoma2253-5969https://doaj.org/article/8934e8c52eb3484a95d672ce9a3b388b2021-11-01T00:00:00Zhttps://www.dovepress.com/role-of-rab-gtpases-in-hepatocellular-carcinoma-peer-reviewed-fulltext-article-JHChttps://doaj.org/toc/2253-5969Chun-Cheng Yang,1,&ast; Guang-Xiao Meng,1,&ast; Zhao-Ru Dong,1,&ast; Tao Li1,2 1Department of General Surgery, Qilu Hospital, Shandong University, Jinan, People’s Republic of China; 2Department of Hepatobiliary Surgery, The Second Hospital of Shandong University, Jinan, People’s Republic of China&ast;These authors contributed equally to this workCorrespondence: Tao Li Tel +86-531-82166651Email litao7706@163.comAbstract: The Rab GTPase family contains almost 70 genes in the human genome and acts as the key regulator of intracellular membrane trafficking in human cells. The dysregulation of Rab GTPase has been shown to be associated with multiple human diseases, ranging from neurodegeneration, and infection to cancer. Rab GTPases not only play important roles in genome replication, morphogenesis and the release of hepatitis B virus (HBV) or hepatitis C virus (HCV), but also contribute to hepatitis-related hepatocarcinogenesis and hepatocellular carcinoma (HCC) progression. The alteration of Rab GTPase expression in HCC plays an important role in tumour cell proliferation, invasion and migration. Notably, the expression of Rab genes can be regulated by some noncoding RNAs, such as miRNAs and circRNAs. Thus, Rab GTPases can serve as promising rational and therapeutic targets for HCC treatments. In this review, we summarized recent advancements in this field focusing on Rab GTPases in HCC.Keywords: Rab GTPase, membrane trafficking, hepatocellular carcinoma, therapeutic targetYang CCMeng GXDong ZRLi TDove Medical Pressarticlerab gtpasemembrane traffickinghepatocellular carcinomatherapeutic targetNeoplasms. Tumors. Oncology. Including cancer and carcinogensRC254-282ENJournal of Hepatocellular Carcinoma, Vol Volume 8, Pp 1389-1397 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	rab gtpase membrane trafficking hepatocellular carcinoma therapeutic target Neoplasms. Tumors. Oncology. Including cancer and carcinogens RC254-282
spellingShingle	rab gtpase membrane trafficking hepatocellular carcinoma therapeutic target Neoplasms. Tumors. Oncology. Including cancer and carcinogens RC254-282 Yang CC Meng GX Dong ZR Li T Role of Rab GTPases in Hepatocellular Carcinoma
description	Chun-Cheng Yang,1,&ast; Guang-Xiao Meng,1,&ast; Zhao-Ru Dong,1,&ast; Tao Li1,2 1Department of General Surgery, Qilu Hospital, Shandong University, Jinan, People’s Republic of China; 2Department of Hepatobiliary Surgery, The Second Hospital of Shandong University, Jinan, People’s Republic of China&ast;These authors contributed equally to this workCorrespondence: Tao Li Tel +86-531-82166651Email litao7706@163.comAbstract: The Rab GTPase family contains almost 70 genes in the human genome and acts as the key regulator of intracellular membrane trafficking in human cells. The dysregulation of Rab GTPase has been shown to be associated with multiple human diseases, ranging from neurodegeneration, and infection to cancer. Rab GTPases not only play important roles in genome replication, morphogenesis and the release of hepatitis B virus (HBV) or hepatitis C virus (HCV), but also contribute to hepatitis-related hepatocarcinogenesis and hepatocellular carcinoma (HCC) progression. The alteration of Rab GTPase expression in HCC plays an important role in tumour cell proliferation, invasion and migration. Notably, the expression of Rab genes can be regulated by some noncoding RNAs, such as miRNAs and circRNAs. Thus, Rab GTPases can serve as promising rational and therapeutic targets for HCC treatments. In this review, we summarized recent advancements in this field focusing on Rab GTPases in HCC.Keywords: Rab GTPase, membrane trafficking, hepatocellular carcinoma, therapeutic target
format	article
author	Yang CC Meng GX Dong ZR Li T
author_facet	Yang CC Meng GX Dong ZR Li T
author_sort	Yang CC
title	Role of Rab GTPases in Hepatocellular Carcinoma
title_short	Role of Rab GTPases in Hepatocellular Carcinoma
title_full	Role of Rab GTPases in Hepatocellular Carcinoma
title_fullStr	Role of Rab GTPases in Hepatocellular Carcinoma
title_full_unstemmed	Role of Rab GTPases in Hepatocellular Carcinoma
title_sort	role of rab gtpases in hepatocellular carcinoma
publisher	Dove Medical Press
publishDate	2021
url	https://doaj.org/article/8934e8c52eb3484a95d672ce9a3b388b
work_keys_str_mv	AT yangcc roleofrabgtpasesinhepatocellularcarcinoma AT menggx roleofrabgtpasesinhepatocellularcarcinoma AT dongzr roleofrabgtpasesinhepatocellularcarcinoma AT lit roleofrabgtpasesinhepatocellularcarcinoma
_version_	1718418712268111872

Role of Rab GTPases in Hepatocellular Carcinoma

Ejemplares similares