Phosphatidylserine on viable sperm and phagocytic machinery in oocytes regulate mammalian fertilization

Izumo and Juno are receptors on sperm and eggs respectively required for fusion, but other factors for sperm-egg fusion are poorly studied. Here, the authors report that phosphatidylserine, found mainly on cells marked for death, is also present on motile sperm, recognized by egg receptors, and is r...

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Autores principales:	Claudia M. Rival, Wenhao Xu, Laura S. Shankman, Sho Morioka, Sanja Arandjelovic, Chang Sup Lee, Karen M. Wheeler, Ryan P. Smith, Lisa B. Haney, Brant E. Isakson, Scott Purcell, Jeffrey J. Lysiak, Kodi S. Ravichandran
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2019
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/89356b6243dc4c859d4c2eaf9ae0cf51
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spelling	oai:doaj.org-article:89356b6243dc4c859d4c2eaf9ae0cf512021-12-02T16:57:51ZPhosphatidylserine on viable sperm and phagocytic machinery in oocytes regulate mammalian fertilization10.1038/s41467-019-12406-z2041-1723https://doaj.org/article/89356b6243dc4c859d4c2eaf9ae0cf512019-10-01T00:00:00Zhttps://doi.org/10.1038/s41467-019-12406-zhttps://doaj.org/toc/2041-1723Izumo and Juno are receptors on sperm and eggs respectively required for fusion, but other factors for sperm-egg fusion are poorly studied. Here, the authors report that phosphatidylserine, found mainly on cells marked for death, is also present on motile sperm, recognized by egg receptors, and is required for sperm-egg fusion.Claudia M. RivalWenhao XuLaura S. ShankmanSho MoriokaSanja ArandjelovicChang Sup LeeKaren M. WheelerRyan P. SmithLisa B. HaneyBrant E. IsaksonScott PurcellJeffrey J. LysiakKodi S. RavichandranNature PortfolioarticleScienceQENNature Communications, Vol 10, Iss 1, Pp 1-13 (2019)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Claudia M. Rival Wenhao Xu Laura S. Shankman Sho Morioka Sanja Arandjelovic Chang Sup Lee Karen M. Wheeler Ryan P. Smith Lisa B. Haney Brant E. Isakson Scott Purcell Jeffrey J. Lysiak Kodi S. Ravichandran Phosphatidylserine on viable sperm and phagocytic machinery in oocytes regulate mammalian fertilization
description	Izumo and Juno are receptors on sperm and eggs respectively required for fusion, but other factors for sperm-egg fusion are poorly studied. Here, the authors report that phosphatidylserine, found mainly on cells marked for death, is also present on motile sperm, recognized by egg receptors, and is required for sperm-egg fusion.
format	article
author	Claudia M. Rival Wenhao Xu Laura S. Shankman Sho Morioka Sanja Arandjelovic Chang Sup Lee Karen M. Wheeler Ryan P. Smith Lisa B. Haney Brant E. Isakson Scott Purcell Jeffrey J. Lysiak Kodi S. Ravichandran
author_facet	Claudia M. Rival Wenhao Xu Laura S. Shankman Sho Morioka Sanja Arandjelovic Chang Sup Lee Karen M. Wheeler Ryan P. Smith Lisa B. Haney Brant E. Isakson Scott Purcell Jeffrey J. Lysiak Kodi S. Ravichandran
author_sort	Claudia M. Rival
title	Phosphatidylserine on viable sperm and phagocytic machinery in oocytes regulate mammalian fertilization
title_short	Phosphatidylserine on viable sperm and phagocytic machinery in oocytes regulate mammalian fertilization
title_full	Phosphatidylserine on viable sperm and phagocytic machinery in oocytes regulate mammalian fertilization
title_fullStr	Phosphatidylserine on viable sperm and phagocytic machinery in oocytes regulate mammalian fertilization
title_full_unstemmed	Phosphatidylserine on viable sperm and phagocytic machinery in oocytes regulate mammalian fertilization
title_sort	phosphatidylserine on viable sperm and phagocytic machinery in oocytes regulate mammalian fertilization
publisher	Nature Portfolio
publishDate	2019
url	https://doaj.org/article/89356b6243dc4c859d4c2eaf9ae0cf51
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Phosphatidylserine on viable sperm and phagocytic machinery in oocytes regulate mammalian fertilization

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