Geometry and Flow Properties Affect the Phase Shift between Pressure and Shear Stress Waves in Blood Vessels

The phase shift between pressure and wall shear stress (WSS) has been associated with vascular diseases such as atherosclerosis and aneurysms. The present study aims to understand the effects of geometry and flow properties on the phase shift under the stiff wall assumption, using an immersed-bounda...

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Autores principales:	Haifeng Wang, Timm Krüger, Fathollah Varnik
Formato:	article
Lenguaje:	EN
Publicado:	MDPI AG 2021
Materias:	phase shift wall shear stress pressure pulsatile blood flow hemodynamics Thermodynamics QC310.15-319 Descriptive and experimental mechanics QC120-168.85
Acceso en línea:	https://doaj.org/article/8937e7f9bc76457a83ec23969a4f9c76
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spelling	oai:doaj.org-article:8937e7f9bc76457a83ec23969a4f9c762021-11-25T17:31:25ZGeometry and Flow Properties Affect the Phase Shift between Pressure and Shear Stress Waves in Blood Vessels10.3390/fluids61103782311-5521https://doaj.org/article/8937e7f9bc76457a83ec23969a4f9c762021-10-01T00:00:00Zhttps://www.mdpi.com/2311-5521/6/11/378https://doaj.org/toc/2311-5521The phase shift between pressure and wall shear stress (WSS) has been associated with vascular diseases such as atherosclerosis and aneurysms. The present study aims to understand the effects of geometry and flow properties on the phase shift under the stiff wall assumption, using an immersed-boundary-lattice-Boltzmann method. For pulsatile flow in a straight pipe, the phase shift is known to increase with the Womersley number, but is independent of the flow speed (or the Reynolds number). For a complex geometry, such as a curved pipe, however, we find that the phase shift develops a strong dependence on the geometry and Reynolds number. We observed that the phase shift at the inner bend of the curved vessel and in the aneurysm dome is larger than that in a straight pipe. Moreover, the geometry affects the connection between the phase shift and other WSS-related metrics, such as time-averaged WSS (TAWSS). For straight and curved blood vessels, the phase shift behaves qualitatively similarly to and can thus be represented by the TAWSS, which is a widely used hemodynamic index. However, these observables significantly differ in other geometries, such as in aneurysms. In such cases, one needs to consider the phase shift as an independent quantity that may carry additional valuable information compared to well-established metrics.Haifeng WangTimm KrügerFathollah VarnikMDPI AGarticlephase shiftwall shear stresspressurepulsatile blood flowhemodynamicsThermodynamicsQC310.15-319Descriptive and experimental mechanicsQC120-168.85ENFluids, Vol 6, Iss 378, p 378 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	phase shift wall shear stress pressure pulsatile blood flow hemodynamics Thermodynamics QC310.15-319 Descriptive and experimental mechanics QC120-168.85
spellingShingle	phase shift wall shear stress pressure pulsatile blood flow hemodynamics Thermodynamics QC310.15-319 Descriptive and experimental mechanics QC120-168.85 Haifeng Wang Timm Krüger Fathollah Varnik Geometry and Flow Properties Affect the Phase Shift between Pressure and Shear Stress Waves in Blood Vessels
description	The phase shift between pressure and wall shear stress (WSS) has been associated with vascular diseases such as atherosclerosis and aneurysms. The present study aims to understand the effects of geometry and flow properties on the phase shift under the stiff wall assumption, using an immersed-boundary-lattice-Boltzmann method. For pulsatile flow in a straight pipe, the phase shift is known to increase with the Womersley number, but is independent of the flow speed (or the Reynolds number). For a complex geometry, such as a curved pipe, however, we find that the phase shift develops a strong dependence on the geometry and Reynolds number. We observed that the phase shift at the inner bend of the curved vessel and in the aneurysm dome is larger than that in a straight pipe. Moreover, the geometry affects the connection between the phase shift and other WSS-related metrics, such as time-averaged WSS (TAWSS). For straight and curved blood vessels, the phase shift behaves qualitatively similarly to and can thus be represented by the TAWSS, which is a widely used hemodynamic index. However, these observables significantly differ in other geometries, such as in aneurysms. In such cases, one needs to consider the phase shift as an independent quantity that may carry additional valuable information compared to well-established metrics.
format	article
author	Haifeng Wang Timm Krüger Fathollah Varnik
author_facet	Haifeng Wang Timm Krüger Fathollah Varnik
author_sort	Haifeng Wang
title	Geometry and Flow Properties Affect the Phase Shift between Pressure and Shear Stress Waves in Blood Vessels
title_short	Geometry and Flow Properties Affect the Phase Shift between Pressure and Shear Stress Waves in Blood Vessels
title_full	Geometry and Flow Properties Affect the Phase Shift between Pressure and Shear Stress Waves in Blood Vessels
title_fullStr	Geometry and Flow Properties Affect the Phase Shift between Pressure and Shear Stress Waves in Blood Vessels
title_full_unstemmed	Geometry and Flow Properties Affect the Phase Shift between Pressure and Shear Stress Waves in Blood Vessels
title_sort	geometry and flow properties affect the phase shift between pressure and shear stress waves in blood vessels
publisher	MDPI AG
publishDate	2021
url	https://doaj.org/article/8937e7f9bc76457a83ec23969a4f9c76
work_keys_str_mv	AT haifengwang geometryandflowpropertiesaffectthephaseshiftbetweenpressureandshearstresswavesinbloodvessels AT timmkruger geometryandflowpropertiesaffectthephaseshiftbetweenpressureandshearstresswavesinbloodvessels AT fathollahvarnik geometryandflowpropertiesaffectthephaseshiftbetweenpressureandshearstresswavesinbloodvessels
_version_	1718412235827576832

Geometry and Flow Properties Affect the Phase Shift between Pressure and Shear Stress Waves in Blood Vessels

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