The tuberculin skin test versus QuantiFERON TB Gold® in predicting tuberculosis disease in an adolescent cohort study in South Africa.
<h4>Setting</h4>This study was conducted in a high tuberculosis (TB) burden area in Worcester, South Africa, with a notified all TB incidence rate of 1,400/100,000.<h4>Main objective</h4>To compare the predictive value of a baseline tuberculin skin test (TST) with that of the...
Guardado en:
| Autores principales: | , , , , , , , , |
|---|---|
| Formato: | article |
| Lenguaje: | EN |
| Publicado: |
Public Library of Science (PLoS)
2011
|
| Materias: | |
| Acceso en línea: | https://doaj.org/article/893c6f24a4cc46168914725948a7fc82 |
| Etiquetas: |
Agregar Etiqueta
Sin Etiquetas, Sea el primero en etiquetar este registro!
|
| id |
oai:doaj.org-article:893c6f24a4cc46168914725948a7fc82 |
|---|---|
| record_format |
dspace |
| spelling |
oai:doaj.org-article:893c6f24a4cc46168914725948a7fc822021-11-18T06:56:38ZThe tuberculin skin test versus QuantiFERON TB Gold® in predicting tuberculosis disease in an adolescent cohort study in South Africa.1932-620310.1371/journal.pone.0017984https://doaj.org/article/893c6f24a4cc46168914725948a7fc822011-03-01T00:00:00Zhttps://www.ncbi.nlm.nih.gov/pmc/articles/pmid/21479236/?tool=EBIhttps://doaj.org/toc/1932-6203<h4>Setting</h4>This study was conducted in a high tuberculosis (TB) burden area in Worcester, South Africa, with a notified all TB incidence rate of 1,400/100,000.<h4>Main objective</h4>To compare the predictive value of a baseline tuberculin skin test (TST) with that of the QuantiFERON TB Gold (In-tube) assay (QFT) for subsequent microbiologically confirmed TB disease among adolescents.<h4>Methods</h4>Adolescents aged 12-18 years were recruited from high schools in the study area. At baseline, blood was drawn for QFT and a TST administered. Participants were followed up for up to 3.8 years for incident TB disease (median 2.4 years).<h4>Results</h4>After exclusions, 5244 (82.4%) of 6,363 adolescents enrolled, were analysed. The TB incidence rate was 0.60 cases per 100 person years (pyrs) (95% CI 0.43-0.82) for baseline TST positive (≥ 5 mm) participants and 0.64 cases per 100 pyrs (95% CI 0.45-0.87) for baseline QFT positive participants. TB incidence rates were 0.22 per 100 pyrs (0.11-0.39) and 0.22 per 100 pyrs (0.12-0.38) among those with a negative baseline TST and QFT respectively. Sensitivity for incident TB disease was 76.9% for TST and 75.0% for QFT (p = 0.81). Positive predictive value was 1.4% for TST and 1.5% for QFT.<h4>Conclusion</h4>Positive TST and QFT tests were moderately sensitive predictors of progression to microbiologically confirmed TB disease. There was no significant difference in the predictive ability of these tests for TB disease amongst adolescents in this high burden setting. Therefore, these findings do not support use of QFT in preference to TST to predict the risk of TB disease in this study population.Hassan MahomedTony HawkridgeSuzanne VerverDeborah AbrahamsLawrence GeiterMark HatherillRodney EhrlichWillem A HanekomGregory D HusseyPublic Library of Science (PLoS)articleMedicineRScienceQENPLoS ONE, Vol 6, Iss 3, p e17984 (2011) |
| institution |
DOAJ |
| collection |
DOAJ |
| language |
EN |
| topic |
Medicine R Science Q |
| spellingShingle |
Medicine R Science Q Hassan Mahomed Tony Hawkridge Suzanne Verver Deborah Abrahams Lawrence Geiter Mark Hatherill Rodney Ehrlich Willem A Hanekom Gregory D Hussey The tuberculin skin test versus QuantiFERON TB Gold® in predicting tuberculosis disease in an adolescent cohort study in South Africa. |
| description |
<h4>Setting</h4>This study was conducted in a high tuberculosis (TB) burden area in Worcester, South Africa, with a notified all TB incidence rate of 1,400/100,000.<h4>Main objective</h4>To compare the predictive value of a baseline tuberculin skin test (TST) with that of the QuantiFERON TB Gold (In-tube) assay (QFT) for subsequent microbiologically confirmed TB disease among adolescents.<h4>Methods</h4>Adolescents aged 12-18 years were recruited from high schools in the study area. At baseline, blood was drawn for QFT and a TST administered. Participants were followed up for up to 3.8 years for incident TB disease (median 2.4 years).<h4>Results</h4>After exclusions, 5244 (82.4%) of 6,363 adolescents enrolled, were analysed. The TB incidence rate was 0.60 cases per 100 person years (pyrs) (95% CI 0.43-0.82) for baseline TST positive (≥ 5 mm) participants and 0.64 cases per 100 pyrs (95% CI 0.45-0.87) for baseline QFT positive participants. TB incidence rates were 0.22 per 100 pyrs (0.11-0.39) and 0.22 per 100 pyrs (0.12-0.38) among those with a negative baseline TST and QFT respectively. Sensitivity for incident TB disease was 76.9% for TST and 75.0% for QFT (p = 0.81). Positive predictive value was 1.4% for TST and 1.5% for QFT.<h4>Conclusion</h4>Positive TST and QFT tests were moderately sensitive predictors of progression to microbiologically confirmed TB disease. There was no significant difference in the predictive ability of these tests for TB disease amongst adolescents in this high burden setting. Therefore, these findings do not support use of QFT in preference to TST to predict the risk of TB disease in this study population. |
| format |
article |
| author |
Hassan Mahomed Tony Hawkridge Suzanne Verver Deborah Abrahams Lawrence Geiter Mark Hatherill Rodney Ehrlich Willem A Hanekom Gregory D Hussey |
| author_facet |
Hassan Mahomed Tony Hawkridge Suzanne Verver Deborah Abrahams Lawrence Geiter Mark Hatherill Rodney Ehrlich Willem A Hanekom Gregory D Hussey |
| author_sort |
Hassan Mahomed |
| title |
The tuberculin skin test versus QuantiFERON TB Gold® in predicting tuberculosis disease in an adolescent cohort study in South Africa. |
| title_short |
The tuberculin skin test versus QuantiFERON TB Gold® in predicting tuberculosis disease in an adolescent cohort study in South Africa. |
| title_full |
The tuberculin skin test versus QuantiFERON TB Gold® in predicting tuberculosis disease in an adolescent cohort study in South Africa. |
| title_fullStr |
The tuberculin skin test versus QuantiFERON TB Gold® in predicting tuberculosis disease in an adolescent cohort study in South Africa. |
| title_full_unstemmed |
The tuberculin skin test versus QuantiFERON TB Gold® in predicting tuberculosis disease in an adolescent cohort study in South Africa. |
| title_sort |
tuberculin skin test versus quantiferon tb gold® in predicting tuberculosis disease in an adolescent cohort study in south africa. |
| publisher |
Public Library of Science (PLoS) |
| publishDate |
2011 |
| url |
https://doaj.org/article/893c6f24a4cc46168914725948a7fc82 |
| work_keys_str_mv |
AT hassanmahomed thetuberculinskintestversusquantiferontbgoldinpredictingtuberculosisdiseaseinanadolescentcohortstudyinsouthafrica AT tonyhawkridge thetuberculinskintestversusquantiferontbgoldinpredictingtuberculosisdiseaseinanadolescentcohortstudyinsouthafrica AT suzanneverver thetuberculinskintestversusquantiferontbgoldinpredictingtuberculosisdiseaseinanadolescentcohortstudyinsouthafrica AT deborahabrahams thetuberculinskintestversusquantiferontbgoldinpredictingtuberculosisdiseaseinanadolescentcohortstudyinsouthafrica AT lawrencegeiter thetuberculinskintestversusquantiferontbgoldinpredictingtuberculosisdiseaseinanadolescentcohortstudyinsouthafrica AT markhatherill thetuberculinskintestversusquantiferontbgoldinpredictingtuberculosisdiseaseinanadolescentcohortstudyinsouthafrica AT rodneyehrlich thetuberculinskintestversusquantiferontbgoldinpredictingtuberculosisdiseaseinanadolescentcohortstudyinsouthafrica AT willemahanekom thetuberculinskintestversusquantiferontbgoldinpredictingtuberculosisdiseaseinanadolescentcohortstudyinsouthafrica AT gregorydhussey thetuberculinskintestversusquantiferontbgoldinpredictingtuberculosisdiseaseinanadolescentcohortstudyinsouthafrica AT hassanmahomed tuberculinskintestversusquantiferontbgoldinpredictingtuberculosisdiseaseinanadolescentcohortstudyinsouthafrica AT tonyhawkridge tuberculinskintestversusquantiferontbgoldinpredictingtuberculosisdiseaseinanadolescentcohortstudyinsouthafrica AT suzanneverver tuberculinskintestversusquantiferontbgoldinpredictingtuberculosisdiseaseinanadolescentcohortstudyinsouthafrica AT deborahabrahams tuberculinskintestversusquantiferontbgoldinpredictingtuberculosisdiseaseinanadolescentcohortstudyinsouthafrica AT lawrencegeiter tuberculinskintestversusquantiferontbgoldinpredictingtuberculosisdiseaseinanadolescentcohortstudyinsouthafrica AT markhatherill tuberculinskintestversusquantiferontbgoldinpredictingtuberculosisdiseaseinanadolescentcohortstudyinsouthafrica AT rodneyehrlich tuberculinskintestversusquantiferontbgoldinpredictingtuberculosisdiseaseinanadolescentcohortstudyinsouthafrica AT willemahanekom tuberculinskintestversusquantiferontbgoldinpredictingtuberculosisdiseaseinanadolescentcohortstudyinsouthafrica AT gregorydhussey tuberculinskintestversusquantiferontbgoldinpredictingtuberculosisdiseaseinanadolescentcohortstudyinsouthafrica |
| _version_ |
1718424178181275648 |