DISTRIBUTION PATTERNS OF ALLELES AND GENOTYPES FOR HLA-G 3'UTR 14-bp ins/del IN MOTHERS OF CHILDREN WITH CONGENITAL HEART DEFECTS OR REPRODUCTIVE LOSSES AT EARLY GESTATION TERMS

HLA-G is the main molecule through which provides tolerance of maternal immune microenvironment to the semi-allogeneic embryo. Polymorphic variant of 14-bp ins/del in the HLA-G 3’UTR gene affects stability and expression of specific mRNA and, thereby, efficiency of immune rejection blockade of the s...

Descripción completa

Guardado en:

Detalles Bibliográficos
Autores principales:	A. V. Shabaldin, A. V. Tsepokina, S. A. Shmulevich, A. V. Ponasenko, P. M. Kryukov, E. V. Shabaldina
Formato:	article
Lenguaje:	RU
Publicado:	SPb RAACI 2017
Materias:	hla-g 3’utr 14-bp ins/del gestation reproductive loss congenital heart diseases Immunologic diseases. Allergy RC581-607
Acceso en línea:	https://doaj.org/article/8943d0a645ec45f890e4605705aaed51
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

id	oai:doaj.org-article:8943d0a645ec45f890e4605705aaed51
record_format	dspace
spelling	oai:doaj.org-article:8943d0a645ec45f890e4605705aaed512021-11-18T08:03:46ZDISTRIBUTION PATTERNS OF ALLELES AND GENOTYPES FOR HLA-G 3'UTR 14-bp ins/del IN MOTHERS OF CHILDREN WITH CONGENITAL HEART DEFECTS OR REPRODUCTIVE LOSSES AT EARLY GESTATION TERMS1563-06252313-741X10.15789/1563-0625-2017-6-763-770https://doaj.org/article/8943d0a645ec45f890e4605705aaed512017-12-01T00:00:00Zhttps://www.mimmun.ru/mimmun/article/view/1400https://doaj.org/toc/1563-0625https://doaj.org/toc/2313-741XHLA-G is the main molecule through which provides tolerance of maternal immune microenvironment to the semi-allogeneic embryo. Polymorphic variant of 14-bp ins/del in the HLA-G 3’UTR gene affects stability and expression of specific mRNA and, thereby, efficiency of immune rejection blockade of the semi-allogeneic embryo. Immune interactions in the “mother – fetus”system can cause teratogenic effects. Congenital heart defects are the dominant pathology among congenital malformations of the fetus and newborns. The aim of the study was to search possible associations between polymorphic 14-bp ins/del variants of maternal HLA-G 3’UTR gene, and reproductive losses or congenital heart defects in their children. Subjects and Methods. We have examined 103 women who had children with congenital heart defects, 21 women with reproductive losses at up to 9 weeks of pregnancy, 101 women with two or more healthy children. Results. It was revealed that the minor homozygous genotype HLA-G 3’UTR 14-bp ins/14-bp ins (OR = 5.25; 95% CI = 1.31-21.11), and allele HLA-G 3’UTR 14-bp ins (OR = 2.34; 95% CI = 1.13-4.84) were markers of early reproductive loss in women. Polymorphic variant of the 14-bp ins/14-bp del gene variant of HLA-G 3’UTR in the mothers was not significantly associated with birth of infants with congenital heart defects.A. V. ShabaldinA. V. TsepokinaS. A. ShmulevichA. V. PonasenkoP. M. KryukovE. V. ShabaldinaSPb RAACIarticlehla-g 3’utr 14-bp ins/delgestationreproductive losscongenital heart diseasesImmunologic diseases. AllergyRC581-607RUMedicinskaâ Immunologiâ, Vol 19, Iss 6, Pp 763-770 (2017)
institution	DOAJ
collection	DOAJ
language	RU
topic	hla-g 3’utr 14-bp ins/del gestation reproductive loss congenital heart diseases Immunologic diseases. Allergy RC581-607
spellingShingle	hla-g 3’utr 14-bp ins/del gestation reproductive loss congenital heart diseases Immunologic diseases. Allergy RC581-607 A. V. Shabaldin A. V. Tsepokina S. A. Shmulevich A. V. Ponasenko P. M. Kryukov E. V. Shabaldina DISTRIBUTION PATTERNS OF ALLELES AND GENOTYPES FOR HLA-G 3'UTR 14-bp ins/del IN MOTHERS OF CHILDREN WITH CONGENITAL HEART DEFECTS OR REPRODUCTIVE LOSSES AT EARLY GESTATION TERMS
description	HLA-G is the main molecule through which provides tolerance of maternal immune microenvironment to the semi-allogeneic embryo. Polymorphic variant of 14-bp ins/del in the HLA-G 3’UTR gene affects stability and expression of specific mRNA and, thereby, efficiency of immune rejection blockade of the semi-allogeneic embryo. Immune interactions in the “mother – fetus”system can cause teratogenic effects. Congenital heart defects are the dominant pathology among congenital malformations of the fetus and newborns. The aim of the study was to search possible associations between polymorphic 14-bp ins/del variants of maternal HLA-G 3’UTR gene, and reproductive losses or congenital heart defects in their children. Subjects and Methods. We have examined 103 women who had children with congenital heart defects, 21 women with reproductive losses at up to 9 weeks of pregnancy, 101 women with two or more healthy children. Results. It was revealed that the minor homozygous genotype HLA-G 3’UTR 14-bp ins/14-bp ins (OR = 5.25; 95% CI = 1.31-21.11), and allele HLA-G 3’UTR 14-bp ins (OR = 2.34; 95% CI = 1.13-4.84) were markers of early reproductive loss in women. Polymorphic variant of the 14-bp ins/14-bp del gene variant of HLA-G 3’UTR in the mothers was not significantly associated with birth of infants with congenital heart defects.
format	article
author	A. V. Shabaldin A. V. Tsepokina S. A. Shmulevich A. V. Ponasenko P. M. Kryukov E. V. Shabaldina
author_facet	A. V. Shabaldin A. V. Tsepokina S. A. Shmulevich A. V. Ponasenko P. M. Kryukov E. V. Shabaldina
author_sort	A. V. Shabaldin
title	DISTRIBUTION PATTERNS OF ALLELES AND GENOTYPES FOR HLA-G 3'UTR 14-bp ins/del IN MOTHERS OF CHILDREN WITH CONGENITAL HEART DEFECTS OR REPRODUCTIVE LOSSES AT EARLY GESTATION TERMS
title_short	DISTRIBUTION PATTERNS OF ALLELES AND GENOTYPES FOR HLA-G 3'UTR 14-bp ins/del IN MOTHERS OF CHILDREN WITH CONGENITAL HEART DEFECTS OR REPRODUCTIVE LOSSES AT EARLY GESTATION TERMS
title_full	DISTRIBUTION PATTERNS OF ALLELES AND GENOTYPES FOR HLA-G 3'UTR 14-bp ins/del IN MOTHERS OF CHILDREN WITH CONGENITAL HEART DEFECTS OR REPRODUCTIVE LOSSES AT EARLY GESTATION TERMS
title_fullStr	DISTRIBUTION PATTERNS OF ALLELES AND GENOTYPES FOR HLA-G 3'UTR 14-bp ins/del IN MOTHERS OF CHILDREN WITH CONGENITAL HEART DEFECTS OR REPRODUCTIVE LOSSES AT EARLY GESTATION TERMS
title_full_unstemmed	DISTRIBUTION PATTERNS OF ALLELES AND GENOTYPES FOR HLA-G 3'UTR 14-bp ins/del IN MOTHERS OF CHILDREN WITH CONGENITAL HEART DEFECTS OR REPRODUCTIVE LOSSES AT EARLY GESTATION TERMS
title_sort	distribution patterns of alleles and genotypes for hla-g 3'utr 14-bp ins/del in mothers of children with congenital heart defects or reproductive losses at early gestation terms
publisher	SPb RAACI
publishDate	2017
url	https://doaj.org/article/8943d0a645ec45f890e4605705aaed51
work_keys_str_mv	AT avshabaldin distributionpatternsofallelesandgenotypesforhlag3utr14bpinsdelinmothersofchildrenwithcongenitalheartdefectsorreproductivelossesatearlygestationterms AT avtsepokina distributionpatternsofallelesandgenotypesforhlag3utr14bpinsdelinmothersofchildrenwithcongenitalheartdefectsorreproductivelossesatearlygestationterms AT sashmulevich distributionpatternsofallelesandgenotypesforhlag3utr14bpinsdelinmothersofchildrenwithcongenitalheartdefectsorreproductivelossesatearlygestationterms AT avponasenko distributionpatternsofallelesandgenotypesforhlag3utr14bpinsdelinmothersofchildrenwithcongenitalheartdefectsorreproductivelossesatearlygestationterms AT pmkryukov distributionpatternsofallelesandgenotypesforhlag3utr14bpinsdelinmothersofchildrenwithcongenitalheartdefectsorreproductivelossesatearlygestationterms AT evshabaldina distributionpatternsofallelesandgenotypesforhlag3utr14bpinsdelinmothersofchildrenwithcongenitalheartdefectsorreproductivelossesatearlygestationterms
_version_	1718422364576808960

DISTRIBUTION PATTERNS OF ALLELES AND GENOTYPES FOR HLA-G 3'UTR 14-bp ins/del IN MOTHERS OF CHILDREN WITH CONGENITAL HEART DEFECTS OR REPRODUCTIVE LOSSES AT EARLY GESTATION TERMS

Ejemplares similares