Relationship between carotid intima media thickness and helminth infections on Flores Island, Indonesia.

<h4>Objective</h4>To examine the association between helminth infections and atherosclerosis.<h4>Background</h4>Chronic helminth infection, which can lead to poor nutritional status and anti-inflammatory response, might protect against the development of atherosclerosis.<h...

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Autores principales: Aprilianto Eddy Wiria, Linda J Wammes, Firdaus Hamid, Olaf M Dekkers, Margaretta A Prasetyani, Linda May, Maria M M Kaisar, Jaco J Verweij, Jouke T Tamsma, Felix Partono, Erliyani Sartono, Taniawati Supali, Maria Yazdanbakhsh, Johannes W A Smit
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spelling oai:doaj.org-article:894630da636d41898b00070d03f566ff2021-11-18T08:00:00ZRelationship between carotid intima media thickness and helminth infections on Flores Island, Indonesia.1932-620310.1371/journal.pone.0054855https://doaj.org/article/894630da636d41898b00070d03f566ff2013-01-01T00:00:00Zhttps://www.ncbi.nlm.nih.gov/pmc/articles/pmid/23365679/pdf/?tool=EBIhttps://doaj.org/toc/1932-6203<h4>Objective</h4>To examine the association between helminth infections and atherosclerosis.<h4>Background</h4>Chronic helminth infection, which can lead to poor nutritional status and anti-inflammatory response, might protect against the development of atherosclerosis.<h4>Methods</h4>A cross-sectional study was performed in Flores, Indonesia, an area highly endemic for soil-transmitted helminths (STH). Stool samples from 675 participants aged 18-80 years were collected and screened for Trichuris trichiura by microscopy and for Ascaris lumbricoides, Necator americanus, Ancylostoma duodenale, and Strongyloides stercoralis by qPCR. We collected data on body mass index (BMI), waist to hip ratio (WHR), blood pressure, fasting blood glucose (FBG), lipid, high sensitive C-reactive protein (hs-CRP), total immunoglobulin-E (TIgE) and Escherichia coli lipopolysaccharide stimulated cytokines (tumor necrosis factor and interleukin-10). In a subset of 301 elderly adults (≥40 years of age) carotid intima media thickness (cIMT) was measured.<h4>Results</h4>Participants with any STH infection had lower BMI (kg/m2) (mean difference -0.66, 95%CI [-1.26, -0.06]), WHR (-0.01, [-0.02, -0.00]), total cholesterol (mmol/L) (-0.22, [-0.43, -0.01]) and LDL-cholesterol (mmol/L) (-0.20, [-0.39, -0.00]) than uninfected participants. After additional adjustment for BMI the association between helminth infection and total cholesterol (mean difference -0.17, 95%CI [-0.37, 0.03]) as well as LDL-cholesterol (-0.15, [-0.33, 0.04]) was less pronounced. BMI, WHR, and total cholesterol were negatively associated with number species of helminth co-infections. Participants with high TIgE, an indicator of exposure to helminths, had lower FBG, TC, and HDL. The association between TIgE and TC and HDL remained significant after adjustment with BMI. No clear association was found between STH infection or TIgE and mean cIMT.<h4>Conclusions</h4>This cross-sectional study presents evidence that helminth infections were negatively associated with risk factors for cardiovascular disease, an association at least partially mediated by an effect on BMI. The significance of this finding needs to be determined.Aprilianto Eddy WiriaLinda J WammesFirdaus HamidOlaf M DekkersMargaretta A PrasetyaniLinda MayMaria M M KaisarJaco J VerweijJouke T TamsmaFelix PartonoErliyani SartonoTaniawati SupaliMaria YazdanbakhshJohannes W A SmitPublic Library of Science (PLoS)articleMedicineRScienceQENPLoS ONE, Vol 8, Iss 1, p e54855 (2013)
institution DOAJ
collection DOAJ
language EN
topic Medicine
R
Science
Q
spellingShingle Medicine
R
Science
Q
Aprilianto Eddy Wiria
Linda J Wammes
Firdaus Hamid
Olaf M Dekkers
Margaretta A Prasetyani
Linda May
Maria M M Kaisar
Jaco J Verweij
Jouke T Tamsma
Felix Partono
Erliyani Sartono
Taniawati Supali
Maria Yazdanbakhsh
Johannes W A Smit
Relationship between carotid intima media thickness and helminth infections on Flores Island, Indonesia.
description <h4>Objective</h4>To examine the association between helminth infections and atherosclerosis.<h4>Background</h4>Chronic helminth infection, which can lead to poor nutritional status and anti-inflammatory response, might protect against the development of atherosclerosis.<h4>Methods</h4>A cross-sectional study was performed in Flores, Indonesia, an area highly endemic for soil-transmitted helminths (STH). Stool samples from 675 participants aged 18-80 years were collected and screened for Trichuris trichiura by microscopy and for Ascaris lumbricoides, Necator americanus, Ancylostoma duodenale, and Strongyloides stercoralis by qPCR. We collected data on body mass index (BMI), waist to hip ratio (WHR), blood pressure, fasting blood glucose (FBG), lipid, high sensitive C-reactive protein (hs-CRP), total immunoglobulin-E (TIgE) and Escherichia coli lipopolysaccharide stimulated cytokines (tumor necrosis factor and interleukin-10). In a subset of 301 elderly adults (≥40 years of age) carotid intima media thickness (cIMT) was measured.<h4>Results</h4>Participants with any STH infection had lower BMI (kg/m2) (mean difference -0.66, 95%CI [-1.26, -0.06]), WHR (-0.01, [-0.02, -0.00]), total cholesterol (mmol/L) (-0.22, [-0.43, -0.01]) and LDL-cholesterol (mmol/L) (-0.20, [-0.39, -0.00]) than uninfected participants. After additional adjustment for BMI the association between helminth infection and total cholesterol (mean difference -0.17, 95%CI [-0.37, 0.03]) as well as LDL-cholesterol (-0.15, [-0.33, 0.04]) was less pronounced. BMI, WHR, and total cholesterol were negatively associated with number species of helminth co-infections. Participants with high TIgE, an indicator of exposure to helminths, had lower FBG, TC, and HDL. The association between TIgE and TC and HDL remained significant after adjustment with BMI. No clear association was found between STH infection or TIgE and mean cIMT.<h4>Conclusions</h4>This cross-sectional study presents evidence that helminth infections were negatively associated with risk factors for cardiovascular disease, an association at least partially mediated by an effect on BMI. The significance of this finding needs to be determined.
format article
author Aprilianto Eddy Wiria
Linda J Wammes
Firdaus Hamid
Olaf M Dekkers
Margaretta A Prasetyani
Linda May
Maria M M Kaisar
Jaco J Verweij
Jouke T Tamsma
Felix Partono
Erliyani Sartono
Taniawati Supali
Maria Yazdanbakhsh
Johannes W A Smit
author_facet Aprilianto Eddy Wiria
Linda J Wammes
Firdaus Hamid
Olaf M Dekkers
Margaretta A Prasetyani
Linda May
Maria M M Kaisar
Jaco J Verweij
Jouke T Tamsma
Felix Partono
Erliyani Sartono
Taniawati Supali
Maria Yazdanbakhsh
Johannes W A Smit
author_sort Aprilianto Eddy Wiria
title Relationship between carotid intima media thickness and helminth infections on Flores Island, Indonesia.
title_short Relationship between carotid intima media thickness and helminth infections on Flores Island, Indonesia.
title_full Relationship between carotid intima media thickness and helminth infections on Flores Island, Indonesia.
title_fullStr Relationship between carotid intima media thickness and helminth infections on Flores Island, Indonesia.
title_full_unstemmed Relationship between carotid intima media thickness and helminth infections on Flores Island, Indonesia.
title_sort relationship between carotid intima media thickness and helminth infections on flores island, indonesia.
publisher Public Library of Science (PLoS)
publishDate 2013
url https://doaj.org/article/894630da636d41898b00070d03f566ff
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