ROLE OF CONTRAST ENHANCED FLAIR MRI AS A NEW TOOL IN DIAGNOSING TUBERCULOUS MENINGITIS

Objective: To determine the diagnostic accuracy of contrast-enhanced FLAIR images as an imaging tool in diagnosing tuberculous meningitis considering CSF analysis as gold standard. Study Design: Comparative Cross sectional Study. Place and Duration of Study: This study was conducted in Radiolo...

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Autores principales:	Riffat Mushtaq, Sadaf Arooj, Ume Kalsoom, Riffat Raja
Formato:	article
Lenguaje:	EN
Publicado:	Army Medical College Rawalpindi 2020
Materias:	meningitis magnetic resonance imaging tuberculous Medicine R Medicine (General) R5-920
Acceso en línea:	https://doaj.org/article/894a0bac53e94377a6019b9c427582d7
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spelling	oai:doaj.org-article:894a0bac53e94377a6019b9c427582d72021-12-02T14:57:43ZROLE OF CONTRAST ENHANCED FLAIR MRI AS A NEW TOOL IN DIAGNOSING TUBERCULOUS MENINGITIS0030-96482411-8842https://doaj.org/article/894a0bac53e94377a6019b9c427582d72020-10-01T00:00:00Zhttps://pafmj.org/index.php/PAFMJ/article/view/5555https://doaj.org/toc/0030-9648https://doaj.org/toc/2411-8842Objective: To determine the diagnostic accuracy of contrast-enhanced FLAIR images as an imaging tool in diagnosing tuberculous meningitis considering CSF analysis as gold standard. Study Design: Comparative Cross sectional Study. Place and Duration of Study: This study was conducted in Radiology Department of Pakistan Institute of Medical Sciences, Islamabad, from May to Oct 2016 in collaboration with Neurology Department. Methodology: Total 255 patients having clinical suspiscion of Tuberculous meningitis were included. Patients having intracranial hemorrhage, claustrophobia and metallic implants in body were excluded. MRI scan of brain from the vertex till the base of skull was performed at 1.5 Tesla MRI machine. Contrast enhanced T2 FLAIR images were acquired and evaluated by radiologists for tuberculous meningitis. CSF analysis was done after lumbar puncture of the patient. Diagnostic accuracy of the procedure was determined by taking CSF analysis as the gold standard. Data was analyzed by using SPSS 21. Results: One hundred and fifty four (61%) patients were found to have abnormal enhancement on contrast enhanced FLAIR images. One hundred and forty six (58.4%) were True Positive and 8 (3.2%) were False Positive. Among, 101 contrast enhanced FLAIR images negative patients, 6 (2.4%) were False Negative where as 95 (38%) were True Negative. Overall sensitivity was 96.05%, specificity 92.23%, positive predictive value 94.81%, negative predictive value 94.06% and diagnostic accuracy 94.51%. Conclusion: This study concluded that contrast-enhanced FLAIR magnetic resonance images have high sensitivity and specificity in diagnosing tuberculous meningitis.Riffat MushtaqSadaf AroojUme KalsoomRiffat RajaArmy Medical College Rawalpindiarticlemeningitismagnetic resonance imagingtuberculousMedicineRMedicine (General)R5-920ENPakistan Armed Forces Medical Journal, Vol 70, Iss 5, Pp 1310-1314 (2020)
institution	DOAJ
collection	DOAJ
language	EN
topic	meningitis magnetic resonance imaging tuberculous Medicine R Medicine (General) R5-920
spellingShingle	meningitis magnetic resonance imaging tuberculous Medicine R Medicine (General) R5-920 Riffat Mushtaq Sadaf Arooj Ume Kalsoom Riffat Raja ROLE OF CONTRAST ENHANCED FLAIR MRI AS A NEW TOOL IN DIAGNOSING TUBERCULOUS MENINGITIS
description	Objective: To determine the diagnostic accuracy of contrast-enhanced FLAIR images as an imaging tool in diagnosing tuberculous meningitis considering CSF analysis as gold standard. Study Design: Comparative Cross sectional Study. Place and Duration of Study: This study was conducted in Radiology Department of Pakistan Institute of Medical Sciences, Islamabad, from May to Oct 2016 in collaboration with Neurology Department. Methodology: Total 255 patients having clinical suspiscion of Tuberculous meningitis were included. Patients having intracranial hemorrhage, claustrophobia and metallic implants in body were excluded. MRI scan of brain from the vertex till the base of skull was performed at 1.5 Tesla MRI machine. Contrast enhanced T2 FLAIR images were acquired and evaluated by radiologists for tuberculous meningitis. CSF analysis was done after lumbar puncture of the patient. Diagnostic accuracy of the procedure was determined by taking CSF analysis as the gold standard. Data was analyzed by using SPSS 21. Results: One hundred and fifty four (61%) patients were found to have abnormal enhancement on contrast enhanced FLAIR images. One hundred and forty six (58.4%) were True Positive and 8 (3.2%) were False Positive. Among, 101 contrast enhanced FLAIR images negative patients, 6 (2.4%) were False Negative where as 95 (38%) were True Negative. Overall sensitivity was 96.05%, specificity 92.23%, positive predictive value 94.81%, negative predictive value 94.06% and diagnostic accuracy 94.51%. Conclusion: This study concluded that contrast-enhanced FLAIR magnetic resonance images have high sensitivity and specificity in diagnosing tuberculous meningitis.
format	article
author	Riffat Mushtaq Sadaf Arooj Ume Kalsoom Riffat Raja
author_facet	Riffat Mushtaq Sadaf Arooj Ume Kalsoom Riffat Raja
author_sort	Riffat Mushtaq
title	ROLE OF CONTRAST ENHANCED FLAIR MRI AS A NEW TOOL IN DIAGNOSING TUBERCULOUS MENINGITIS
title_short	ROLE OF CONTRAST ENHANCED FLAIR MRI AS A NEW TOOL IN DIAGNOSING TUBERCULOUS MENINGITIS
title_full	ROLE OF CONTRAST ENHANCED FLAIR MRI AS A NEW TOOL IN DIAGNOSING TUBERCULOUS MENINGITIS
title_fullStr	ROLE OF CONTRAST ENHANCED FLAIR MRI AS A NEW TOOL IN DIAGNOSING TUBERCULOUS MENINGITIS
title_full_unstemmed	ROLE OF CONTRAST ENHANCED FLAIR MRI AS A NEW TOOL IN DIAGNOSING TUBERCULOUS MENINGITIS
title_sort	role of contrast enhanced flair mri as a new tool in diagnosing tuberculous meningitis
publisher	Army Medical College Rawalpindi
publishDate	2020
url	https://doaj.org/article/894a0bac53e94377a6019b9c427582d7
work_keys_str_mv	AT riffatmushtaq roleofcontrastenhancedflairmriasanewtoolindiagnosingtuberculousmeningitis AT sadafarooj roleofcontrastenhancedflairmriasanewtoolindiagnosingtuberculousmeningitis AT umekalsoom roleofcontrastenhancedflairmriasanewtoolindiagnosingtuberculousmeningitis AT riffatraja roleofcontrastenhancedflairmriasanewtoolindiagnosingtuberculousmeningitis
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ROLE OF CONTRAST ENHANCED FLAIR MRI AS A NEW TOOL IN DIAGNOSING TUBERCULOUS MENINGITIS

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