Gα13 negatively controls osteoclastogenesis through inhibition of the Akt-GSK3β-NFATc1 signalling pathway

Osteoclasts are bone resorptive cells and an attractive target to treat diseases characterized by excessive bone loss, but little is known about osteoclast inhibition. Here the authors identify Gα13 as an intracellular inhibitor of osteoclastogenesis that can prevent bone loss in mice via Akt activa...

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Autores principales:	Mengrui Wu, Wei Chen, Yun Lu, Guochun Zhu, Liang Hao, Yi-Ping Li
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2017
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/894ba48cf3414f0496ecae4427ee512b
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spelling	oai:doaj.org-article:894ba48cf3414f0496ecae4427ee512b2021-12-02T14:40:25ZGα13 negatively controls osteoclastogenesis through inhibition of the Akt-GSK3β-NFATc1 signalling pathway10.1038/ncomms137002041-1723https://doaj.org/article/894ba48cf3414f0496ecae4427ee512b2017-01-01T00:00:00Zhttps://doi.org/10.1038/ncomms13700https://doaj.org/toc/2041-1723Osteoclasts are bone resorptive cells and an attractive target to treat diseases characterized by excessive bone loss, but little is known about osteoclast inhibition. Here the authors identify Gα13 as an intracellular inhibitor of osteoclastogenesis that can prevent bone loss in mice via Akt activation and inhibition of RhoA signalling.Mengrui WuWei ChenYun LuGuochun ZhuLiang HaoYi-Ping LiNature PortfolioarticleScienceQENNature Communications, Vol 8, Iss 1, Pp 1-13 (2017)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Mengrui Wu Wei Chen Yun Lu Guochun Zhu Liang Hao Yi-Ping Li Gα13 negatively controls osteoclastogenesis through inhibition of the Akt-GSK3β-NFATc1 signalling pathway
description	Osteoclasts are bone resorptive cells and an attractive target to treat diseases characterized by excessive bone loss, but little is known about osteoclast inhibition. Here the authors identify Gα13 as an intracellular inhibitor of osteoclastogenesis that can prevent bone loss in mice via Akt activation and inhibition of RhoA signalling.
format	article
author	Mengrui Wu Wei Chen Yun Lu Guochun Zhu Liang Hao Yi-Ping Li
author_facet	Mengrui Wu Wei Chen Yun Lu Guochun Zhu Liang Hao Yi-Ping Li
author_sort	Mengrui Wu
title	Gα13 negatively controls osteoclastogenesis through inhibition of the Akt-GSK3β-NFATc1 signalling pathway
title_short	Gα13 negatively controls osteoclastogenesis through inhibition of the Akt-GSK3β-NFATc1 signalling pathway
title_full	Gα13 negatively controls osteoclastogenesis through inhibition of the Akt-GSK3β-NFATc1 signalling pathway
title_fullStr	Gα13 negatively controls osteoclastogenesis through inhibition of the Akt-GSK3β-NFATc1 signalling pathway
title_full_unstemmed	Gα13 negatively controls osteoclastogenesis through inhibition of the Akt-GSK3β-NFATc1 signalling pathway
title_sort	gα13 negatively controls osteoclastogenesis through inhibition of the akt-gsk3β-nfatc1 signalling pathway
publisher	Nature Portfolio
publishDate	2017
url	https://doaj.org/article/894ba48cf3414f0496ecae4427ee512b
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Gα13 negatively controls osteoclastogenesis through inhibition of the Akt-GSK3β-NFATc1 signalling pathway

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