Exosomes harbor B cell targets in pancreatic adenocarcinoma and exert decoy function against complement-mediated cytotoxicity

Exosomes harbor B cell targets in pancreatic adenocarcinoma and exert decoy function against complement-mediated cytotoxicity

The humoral immune response role in cancer is unclear. Here the authors perform an in-depth proteomic profiling of immunoglobulin-bound proteins in plasma from pancreatic ductal adenocarcinoma patients and find cancer-cell specific antibodies neutralized by binding to cancer-cell derived exosomes.

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Detalles Bibliográficos
Autores principales: Michela Capello, Jody V. Vykoukal, Hiroyuki Katayama, Leonidas E. Bantis, Hong Wang, Deepali L. Kundnani, Clemente Aguilar-Bonavides, Mitzi Aguilar, Satyendra C. Tripathi, Dilsher S. Dhillon, Amin A. Momin, Haley Peters, Matthew H. Katz, Hector Alvarez, Vincent Bernard, Sammy Ferri-Borgogno, Randall Brand, Douglas G. Adler, Matthew A. Firpo, Sean J. Mulvihill, Jeffrey J. Molldrem, Ziding Feng, Ayumu Taguchi, Anirban Maitra, Samir M. Hanash
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2019
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Science
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Acceso en línea:https://doaj.org/article/894d022900ed4b4e8044c96aa2442e1e
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Descripción
Sumario:The humoral immune response role in cancer is unclear. Here the authors perform an in-depth proteomic profiling of immunoglobulin-bound proteins in plasma from pancreatic ductal adenocarcinoma patients and find cancer-cell specific antibodies neutralized by binding to cancer-cell derived exosomes.

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