Exosomes harbor B cell targets in pancreatic adenocarcinoma and exert decoy function against complement-mediated cytotoxicity
The humoral immune response role in cancer is unclear. Here the authors perform an in-depth proteomic profiling of immunoglobulin-bound proteins in plasma from pancreatic ductal adenocarcinoma patients and find cancer-cell specific antibodies neutralized by binding to cancer-cell derived exosomes.
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Nature Portfolio
2019
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oai:doaj.org-article:894d022900ed4b4e8044c96aa2442e1e2021-12-02T14:38:58ZExosomes harbor B cell targets in pancreatic adenocarcinoma and exert decoy function against complement-mediated cytotoxicity10.1038/s41467-018-08109-62041-1723https://doaj.org/article/894d022900ed4b4e8044c96aa2442e1e2019-01-01T00:00:00Zhttps://doi.org/10.1038/s41467-018-08109-6https://doaj.org/toc/2041-1723The humoral immune response role in cancer is unclear. Here the authors perform an in-depth proteomic profiling of immunoglobulin-bound proteins in plasma from pancreatic ductal adenocarcinoma patients and find cancer-cell specific antibodies neutralized by binding to cancer-cell derived exosomes.Michela CapelloJody V. VykoukalHiroyuki KatayamaLeonidas E. BantisHong WangDeepali L. KundnaniClemente Aguilar-BonavidesMitzi AguilarSatyendra C. TripathiDilsher S. DhillonAmin A. MominHaley PetersMatthew H. KatzHector AlvarezVincent BernardSammy Ferri-BorgognoRandall BrandDouglas G. AdlerMatthew A. FirpoSean J. MulvihillJeffrey J. MolldremZiding FengAyumu TaguchiAnirban MaitraSamir M. HanashNature PortfolioarticleScienceQENNature Communications, Vol 10, Iss 1, Pp 1-13 (2019) |
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DOAJ |
| collection |
DOAJ |
| language |
EN |
| topic |
Science Q |
| spellingShingle |
Science Q Michela Capello Jody V. Vykoukal Hiroyuki Katayama Leonidas E. Bantis Hong Wang Deepali L. Kundnani Clemente Aguilar-Bonavides Mitzi Aguilar Satyendra C. Tripathi Dilsher S. Dhillon Amin A. Momin Haley Peters Matthew H. Katz Hector Alvarez Vincent Bernard Sammy Ferri-Borgogno Randall Brand Douglas G. Adler Matthew A. Firpo Sean J. Mulvihill Jeffrey J. Molldrem Ziding Feng Ayumu Taguchi Anirban Maitra Samir M. Hanash Exosomes harbor B cell targets in pancreatic adenocarcinoma and exert decoy function against complement-mediated cytotoxicity |
| description |
The humoral immune response role in cancer is unclear. Here the authors perform an in-depth proteomic profiling of immunoglobulin-bound proteins in plasma from pancreatic ductal adenocarcinoma patients and find cancer-cell specific antibodies neutralized by binding to cancer-cell derived exosomes. |
| format |
article |
| author |
Michela Capello Jody V. Vykoukal Hiroyuki Katayama Leonidas E. Bantis Hong Wang Deepali L. Kundnani Clemente Aguilar-Bonavides Mitzi Aguilar Satyendra C. Tripathi Dilsher S. Dhillon Amin A. Momin Haley Peters Matthew H. Katz Hector Alvarez Vincent Bernard Sammy Ferri-Borgogno Randall Brand Douglas G. Adler Matthew A. Firpo Sean J. Mulvihill Jeffrey J. Molldrem Ziding Feng Ayumu Taguchi Anirban Maitra Samir M. Hanash |
| author_facet |
Michela Capello Jody V. Vykoukal Hiroyuki Katayama Leonidas E. Bantis Hong Wang Deepali L. Kundnani Clemente Aguilar-Bonavides Mitzi Aguilar Satyendra C. Tripathi Dilsher S. Dhillon Amin A. Momin Haley Peters Matthew H. Katz Hector Alvarez Vincent Bernard Sammy Ferri-Borgogno Randall Brand Douglas G. Adler Matthew A. Firpo Sean J. Mulvihill Jeffrey J. Molldrem Ziding Feng Ayumu Taguchi Anirban Maitra Samir M. Hanash |
| author_sort |
Michela Capello |
| title |
Exosomes harbor B cell targets in pancreatic adenocarcinoma and exert decoy function against complement-mediated cytotoxicity |
| title_short |
Exosomes harbor B cell targets in pancreatic adenocarcinoma and exert decoy function against complement-mediated cytotoxicity |
| title_full |
Exosomes harbor B cell targets in pancreatic adenocarcinoma and exert decoy function against complement-mediated cytotoxicity |
| title_fullStr |
Exosomes harbor B cell targets in pancreatic adenocarcinoma and exert decoy function against complement-mediated cytotoxicity |
| title_full_unstemmed |
Exosomes harbor B cell targets in pancreatic adenocarcinoma and exert decoy function against complement-mediated cytotoxicity |
| title_sort |
exosomes harbor b cell targets in pancreatic adenocarcinoma and exert decoy function against complement-mediated cytotoxicity |
| publisher |
Nature Portfolio |
| publishDate |
2019 |
| url |
https://doaj.org/article/894d022900ed4b4e8044c96aa2442e1e |
| work_keys_str_mv |
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