Seroprevalence of SARS-CoV-2 IgG antibodies and risk factors in health care workers at an academic medical center in Boston, Massachusetts

Abstract Healthcare workers (HCWs) are at an increased risk of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), a novel virus that causes Coronavirus Disease (COVID-19). We aim to assess the seroprevalence of SARS-CoV-2 IgG among healthcare workers and compare risk-factors between serop...

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Autores principales:	Yachana Kataria, Manisha Cole, Elizabeth Duffy, Kyle de la Cena, Elissa M. Schechter-Perkins, Tara C. Bouton, Martha M. Werler, Cassandra Pierre, Elizabeth J. Ragan, Sarah E. Weber, Karen R. Jacobson, Chris Andry
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/8950890f741b403c90cdd7a0522c869d
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spelling	oai:doaj.org-article:8950890f741b403c90cdd7a0522c869d2021-12-02T14:49:43ZSeroprevalence of SARS-CoV-2 IgG antibodies and risk factors in health care workers at an academic medical center in Boston, Massachusetts10.1038/s41598-021-89107-52045-2322https://doaj.org/article/8950890f741b403c90cdd7a0522c869d2021-05-01T00:00:00Zhttps://doi.org/10.1038/s41598-021-89107-5https://doaj.org/toc/2045-2322Abstract Healthcare workers (HCWs) are at an increased risk of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), a novel virus that causes Coronavirus Disease (COVID-19). We aim to assess the seroprevalence of SARS-CoV-2 IgG among healthcare workers and compare risk-factors between seropositive and seronegative HCWs. In this observational study, serum samples were collected from HCWs between July 13th to 26th, 2020 at Boston Medical Center (BMC). Samples were subsequently tested for SARS-CoV-2 IgG antibody using the Abbott SARS-CoV-2 IgG assay. Participants also answered a questionnaire capturing data on demographics, history of COVID-19 symptoms, occupation, infection prevention and control measures. Overall, 95 of 1743 (5.5%) participants tested positive for SARS-CoV-2 IgG. Of these, 1.8% of the participants had mild or no COVID-19 symptoms and did not require a diagnostic test. Seropositivity was not associated with gender, occupation, hand hygiene and personal protective equipment (PPE) practices amongst HCWs. However, lack of physical distancing among health care workers in work areas and break room was associated with seropositivity (p = 0.05, p = 0.003, respectively). The majority of the HCWs are negative for SARS-CoV-2 IgG. This data highlights the need to promote infection prevention measures, and the importance of distance amongst co-workers to help mitigate infection rates.Yachana KatariaManisha ColeElizabeth DuffyKyle de la CenaElissa M. Schechter-PerkinsTara C. BoutonMartha M. WerlerCassandra PierreElizabeth J. RaganSarah E. WeberKaren R. JacobsonChris AndryNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 11, Iss 1, Pp 1-9 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Yachana Kataria Manisha Cole Elizabeth Duffy Kyle de la Cena Elissa M. Schechter-Perkins Tara C. Bouton Martha M. Werler Cassandra Pierre Elizabeth J. Ragan Sarah E. Weber Karen R. Jacobson Chris Andry Seroprevalence of SARS-CoV-2 IgG antibodies and risk factors in health care workers at an academic medical center in Boston, Massachusetts
description	Abstract Healthcare workers (HCWs) are at an increased risk of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), a novel virus that causes Coronavirus Disease (COVID-19). We aim to assess the seroprevalence of SARS-CoV-2 IgG among healthcare workers and compare risk-factors between seropositive and seronegative HCWs. In this observational study, serum samples were collected from HCWs between July 13th to 26th, 2020 at Boston Medical Center (BMC). Samples were subsequently tested for SARS-CoV-2 IgG antibody using the Abbott SARS-CoV-2 IgG assay. Participants also answered a questionnaire capturing data on demographics, history of COVID-19 symptoms, occupation, infection prevention and control measures. Overall, 95 of 1743 (5.5%) participants tested positive for SARS-CoV-2 IgG. Of these, 1.8% of the participants had mild or no COVID-19 symptoms and did not require a diagnostic test. Seropositivity was not associated with gender, occupation, hand hygiene and personal protective equipment (PPE) practices amongst HCWs. However, lack of physical distancing among health care workers in work areas and break room was associated with seropositivity (p = 0.05, p = 0.003, respectively). The majority of the HCWs are negative for SARS-CoV-2 IgG. This data highlights the need to promote infection prevention measures, and the importance of distance amongst co-workers to help mitigate infection rates.
format	article
author	Yachana Kataria Manisha Cole Elizabeth Duffy Kyle de la Cena Elissa M. Schechter-Perkins Tara C. Bouton Martha M. Werler Cassandra Pierre Elizabeth J. Ragan Sarah E. Weber Karen R. Jacobson Chris Andry
author_facet	Yachana Kataria Manisha Cole Elizabeth Duffy Kyle de la Cena Elissa M. Schechter-Perkins Tara C. Bouton Martha M. Werler Cassandra Pierre Elizabeth J. Ragan Sarah E. Weber Karen R. Jacobson Chris Andry
author_sort	Yachana Kataria
title	Seroprevalence of SARS-CoV-2 IgG antibodies and risk factors in health care workers at an academic medical center in Boston, Massachusetts
title_short	Seroprevalence of SARS-CoV-2 IgG antibodies and risk factors in health care workers at an academic medical center in Boston, Massachusetts
title_full	Seroprevalence of SARS-CoV-2 IgG antibodies and risk factors in health care workers at an academic medical center in Boston, Massachusetts
title_fullStr	Seroprevalence of SARS-CoV-2 IgG antibodies and risk factors in health care workers at an academic medical center in Boston, Massachusetts
title_full_unstemmed	Seroprevalence of SARS-CoV-2 IgG antibodies and risk factors in health care workers at an academic medical center in Boston, Massachusetts
title_sort	seroprevalence of sars-cov-2 igg antibodies and risk factors in health care workers at an academic medical center in boston, massachusetts
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/8950890f741b403c90cdd7a0522c869d
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Seroprevalence of SARS-CoV-2 IgG antibodies and risk factors in health care workers at an academic medical center in Boston, Massachusetts

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