A critical role of PRDM14 in human primordial germ cell fate revealed by inducible degrons

A critical role of PRDM14 in human primordial germ cell fate revealed by inducible degrons

PRDM14 is a critical transcription factor for mouse primordial germ cell specification, but its role in human remains unclear. Here, PRDM14 protein depletion using auxin-inducible degron uncovers a critical role for human germ cell specification, but regulation of a different set of target genes tha...

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Autores principales: Anastasiya Sybirna, Walfred W. C. Tang, Merrick Pierson Smela, Sabine Dietmann, Wolfram H. Gruhn, Ran Brosh, M. Azim Surani
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2020
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Acceso en línea:https://doaj.org/article/89513bd8995b4d72af1095f2f4ba77c1
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spelling oai:doaj.org-article:89513bd8995b4d72af1095f2f4ba77c12021-12-02T16:56:35ZA critical role of PRDM14 in human primordial germ cell fate revealed by inducible degrons10.1038/s41467-020-15042-02041-1723https://doaj.org/article/89513bd8995b4d72af1095f2f4ba77c12020-03-01T00:00:00Zhttps://doi.org/10.1038/s41467-020-15042-0https://doaj.org/toc/2041-1723PRDM14 is a critical transcription factor for mouse primordial germ cell specification, but its role in human remains unclear. Here, PRDM14 protein depletion using auxin-inducible degron uncovers a critical role for human germ cell specification, but regulation of a different set of target genes than in mouse.Anastasiya SybirnaWalfred W. C. TangMerrick Pierson SmelaSabine DietmannWolfram H. GruhnRan BroshM. Azim SuraniNature PortfolioarticleScienceQENNature Communications, Vol 11, Iss 1, Pp 1-18 (2020)
institution DOAJ
collection DOAJ
language EN
topic Science
Q
spellingShingle Science
Q
Anastasiya Sybirna
Walfred W. C. Tang
Merrick Pierson Smela
Sabine Dietmann
Wolfram H. Gruhn
Ran Brosh
M. Azim Surani
A critical role of PRDM14 in human primordial germ cell fate revealed by inducible degrons
description PRDM14 is a critical transcription factor for mouse primordial germ cell specification, but its role in human remains unclear. Here, PRDM14 protein depletion using auxin-inducible degron uncovers a critical role for human germ cell specification, but regulation of a different set of target genes than in mouse.
format article
author Anastasiya Sybirna
Walfred W. C. Tang
Merrick Pierson Smela
Sabine Dietmann
Wolfram H. Gruhn
Ran Brosh
M. Azim Surani
author_facet Anastasiya Sybirna
Walfred W. C. Tang
Merrick Pierson Smela
Sabine Dietmann
Wolfram H. Gruhn
Ran Brosh
M. Azim Surani
author_sort Anastasiya Sybirna
title A critical role of PRDM14 in human primordial germ cell fate revealed by inducible degrons
title_short A critical role of PRDM14 in human primordial germ cell fate revealed by inducible degrons
title_full A critical role of PRDM14 in human primordial germ cell fate revealed by inducible degrons
title_fullStr A critical role of PRDM14 in human primordial germ cell fate revealed by inducible degrons
title_full_unstemmed A critical role of PRDM14 in human primordial germ cell fate revealed by inducible degrons
title_sort critical role of prdm14 in human primordial germ cell fate revealed by inducible degrons
publisher Nature Portfolio
publishDate 2020
url https://doaj.org/article/89513bd8995b4d72af1095f2f4ba77c1
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