Cardiac Conduction Velocity, Remodeling and Arrhythmogenesis

Cardiac electrophysiological disorders, in particular arrhythmias, are a key cause of morbidity and mortality throughout the world. There are two basic requirements for arrhythmogenesis: an underlying substrate and a trigger. Altered conduction velocity (CV) provides a key substrate for arrhythmogen...

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Autores principales:	Bo Han, Mark L. Trew, Callum M. Zgierski-Johnston
Formato:	article
Lenguaje:	EN
Publicado:	MDPI AG 2021
Materias:	conduction velocity arrhythmogenesis methodology anisotropy inhomogeneity gap junction Biology (General) QH301-705.5
Acceso en línea:	https://doaj.org/article/8951c843efde4660813d828e9dd29b95
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id	oai:doaj.org-article:8951c843efde4660813d828e9dd29b95
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spelling	oai:doaj.org-article:8951c843efde4660813d828e9dd29b952021-11-25T17:08:56ZCardiac Conduction Velocity, Remodeling and Arrhythmogenesis10.3390/cells101129232073-4409https://doaj.org/article/8951c843efde4660813d828e9dd29b952021-10-01T00:00:00Zhttps://www.mdpi.com/2073-4409/10/11/2923https://doaj.org/toc/2073-4409Cardiac electrophysiological disorders, in particular arrhythmias, are a key cause of morbidity and mortality throughout the world. There are two basic requirements for arrhythmogenesis: an underlying substrate and a trigger. Altered conduction velocity (CV) provides a key substrate for arrhythmogenesis, with slowed CV increasing the probability of re-entrant arrhythmias by reducing the length scale over which re-entry can occur. In this review, we examine methods to measure cardiac CV in vivo and ex vivo, discuss underlying determinants of CV, and address how pathological variations alter CV, potentially increasing arrhythmogenic risk. Finally, we will highlight future directions both for methodologies to measure CV and for possible treatments to restore normal CV.Bo HanMark L. TrewCallum M. Zgierski-JohnstonMDPI AGarticleconduction velocityarrhythmogenesismethodologyanisotropyinhomogeneitygap junctionBiology (General)QH301-705.5ENCells, Vol 10, Iss 2923, p 2923 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	conduction velocity arrhythmogenesis methodology anisotropy inhomogeneity gap junction Biology (General) QH301-705.5
spellingShingle	conduction velocity arrhythmogenesis methodology anisotropy inhomogeneity gap junction Biology (General) QH301-705.5 Bo Han Mark L. Trew Callum M. Zgierski-Johnston Cardiac Conduction Velocity, Remodeling and Arrhythmogenesis
description	Cardiac electrophysiological disorders, in particular arrhythmias, are a key cause of morbidity and mortality throughout the world. There are two basic requirements for arrhythmogenesis: an underlying substrate and a trigger. Altered conduction velocity (CV) provides a key substrate for arrhythmogenesis, with slowed CV increasing the probability of re-entrant arrhythmias by reducing the length scale over which re-entry can occur. In this review, we examine methods to measure cardiac CV in vivo and ex vivo, discuss underlying determinants of CV, and address how pathological variations alter CV, potentially increasing arrhythmogenic risk. Finally, we will highlight future directions both for methodologies to measure CV and for possible treatments to restore normal CV.
format	article
author	Bo Han Mark L. Trew Callum M. Zgierski-Johnston
author_facet	Bo Han Mark L. Trew Callum M. Zgierski-Johnston
author_sort	Bo Han
title	Cardiac Conduction Velocity, Remodeling and Arrhythmogenesis
title_short	Cardiac Conduction Velocity, Remodeling and Arrhythmogenesis
title_full	Cardiac Conduction Velocity, Remodeling and Arrhythmogenesis
title_fullStr	Cardiac Conduction Velocity, Remodeling and Arrhythmogenesis
title_full_unstemmed	Cardiac Conduction Velocity, Remodeling and Arrhythmogenesis
title_sort	cardiac conduction velocity, remodeling and arrhythmogenesis
publisher	MDPI AG
publishDate	2021
url	https://doaj.org/article/8951c843efde4660813d828e9dd29b95
work_keys_str_mv	AT bohan cardiacconductionvelocityremodelingandarrhythmogenesis AT markltrew cardiacconductionvelocityremodelingandarrhythmogenesis AT callummzgierskijohnston cardiacconductionvelocityremodelingandarrhythmogenesis
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Cardiac Conduction Velocity, Remodeling and Arrhythmogenesis

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