An exploratory study on CLU, CR1 and PICALM and Parkinson disease.

<h4>Background</h4>Recent GWAS and subsequent confirmation studies reported several single-nucleotide polymorphisms (SNPs) at the CLU, CR1 and PICALM loci in association with late-onset Alzheimer's disease (AD). Parkinson disease (PD) shares several clinical and pathologic character...

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Autores principales:	Jianjun Gao, Xuemei Huang, Yikyung Park, Albert Hollenbeck, Honglei Chen
Formato:	article
Lenguaje:	EN
Publicado:	Public Library of Science (PLoS) 2011
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/895a32b5ffed4e798ed062ce22c96822
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spelling	oai:doaj.org-article:895a32b5ffed4e798ed062ce22c968222021-11-18T06:47:02ZAn exploratory study on CLU, CR1 and PICALM and Parkinson disease.1932-620310.1371/journal.pone.0024211https://doaj.org/article/895a32b5ffed4e798ed062ce22c968222011-01-01T00:00:00Zhttps://www.ncbi.nlm.nih.gov/pmc/articles/pmid/21912625/pdf/?tool=EBIhttps://doaj.org/toc/1932-6203<h4>Background</h4>Recent GWAS and subsequent confirmation studies reported several single-nucleotide polymorphisms (SNPs) at the CLU, CR1 and PICALM loci in association with late-onset Alzheimer's disease (AD). Parkinson disease (PD) shares several clinical and pathologic characteristics with AD; we therefore explored whether these SNPs were also associated with PD risk.<h4>Methodology/principal findings</h4>791 non-Hispanic Whites cases and 1,580 matched controls were included in the study. Odds ratios (OR) and 95% confidence intervals (CI) were obtained from logistic regression models. rs11136000 at the CLU locus was associated with PD risk under the recessive model (comparing TT versus CC+CT: OR = 0.71, 95% CI: 0.55-0.92, p = 0.008) after adjusting for year of birth, gender, smoking, and caffeine intake. Further adjustment for family history of PD and ApoE ε4 status did not change the result. In addition, we did not find evidence for effect modification by ApoE or known PD risk factors. The association, however, appeared to be stronger for PD with dementia (OR = 0.49, 95% CI: 0.27-0.91) than for PD without dementia (OR = 0.81, 95% CI: 0.61-1.06). The two other SNPs, rs6656401 from CR1, and rs3851179 from PICALM region were not associated with PD (p>0.05).<h4>Conclusion</h4>Our exploratory analysis suggests an association of CLU with PD. This exploratory finding and the role of dementia in explaining this finding needs further investigation.Jianjun GaoXuemei HuangYikyung ParkAlbert HollenbeckHonglei ChenPublic Library of Science (PLoS)articleMedicineRScienceQENPLoS ONE, Vol 6, Iss 8, p e24211 (2011)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Jianjun Gao Xuemei Huang Yikyung Park Albert Hollenbeck Honglei Chen An exploratory study on CLU, CR1 and PICALM and Parkinson disease.
description	<h4>Background</h4>Recent GWAS and subsequent confirmation studies reported several single-nucleotide polymorphisms (SNPs) at the CLU, CR1 and PICALM loci in association with late-onset Alzheimer's disease (AD). Parkinson disease (PD) shares several clinical and pathologic characteristics with AD; we therefore explored whether these SNPs were also associated with PD risk.<h4>Methodology/principal findings</h4>791 non-Hispanic Whites cases and 1,580 matched controls were included in the study. Odds ratios (OR) and 95% confidence intervals (CI) were obtained from logistic regression models. rs11136000 at the CLU locus was associated with PD risk under the recessive model (comparing TT versus CC+CT: OR = 0.71, 95% CI: 0.55-0.92, p = 0.008) after adjusting for year of birth, gender, smoking, and caffeine intake. Further adjustment for family history of PD and ApoE ε4 status did not change the result. In addition, we did not find evidence for effect modification by ApoE or known PD risk factors. The association, however, appeared to be stronger for PD with dementia (OR = 0.49, 95% CI: 0.27-0.91) than for PD without dementia (OR = 0.81, 95% CI: 0.61-1.06). The two other SNPs, rs6656401 from CR1, and rs3851179 from PICALM region were not associated with PD (p>0.05).<h4>Conclusion</h4>Our exploratory analysis suggests an association of CLU with PD. This exploratory finding and the role of dementia in explaining this finding needs further investigation.
format	article
author	Jianjun Gao Xuemei Huang Yikyung Park Albert Hollenbeck Honglei Chen
author_facet	Jianjun Gao Xuemei Huang Yikyung Park Albert Hollenbeck Honglei Chen
author_sort	Jianjun Gao
title	An exploratory study on CLU, CR1 and PICALM and Parkinson disease.
title_short	An exploratory study on CLU, CR1 and PICALM and Parkinson disease.
title_full	An exploratory study on CLU, CR1 and PICALM and Parkinson disease.
title_fullStr	An exploratory study on CLU, CR1 and PICALM and Parkinson disease.
title_full_unstemmed	An exploratory study on CLU, CR1 and PICALM and Parkinson disease.
title_sort	exploratory study on clu, cr1 and picalm and parkinson disease.
publisher	Public Library of Science (PLoS)
publishDate	2011
url	https://doaj.org/article/895a32b5ffed4e798ed062ce22c96822
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An exploratory study on CLU, CR1 and PICALM and Parkinson disease.

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